Summary
ITIM-bearing NK receptors for MHC class I molecules (NKR) can impair NK cell activation programs and confer to NK cells the capacity to discriminate between MHC class I+ and MHC class I− target cells. Inhibitory NKR are thus involved in the control of NK tolerance to self. A subset of T cells also express inhibitory NKR at the cell surface. We refer to these cells as Tml cells (T memory type 1 cells), and describe here the phenotypic and functional features of this subset of memory-phenotype CD8+ T cells. This analysis reveals a novel biological function for inhibitory NKR when expressed on T cells. Indeed, sensing of self-MHC class I molecules by inhibitory NKR displayed on T cell surface leads to the in vivo accumulation of Tml cells.
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References
André P, Brunet C, Guia S, Gallais H, Sampol J, Vivier E, Dignat-George F (1999) Differential regulation of killer cell Ig-like receptors and CD94 lectin-like dimers on NK and T lymphocytes from HIV-1-infected individuals. Eur J Immunol 29: 1076–1085
André P, Spertini O, Guia S, Rihet P, Dignat-George F, Brailly H, Sampol J, Anderson PJ, Vivier E (2000) Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin. Proc Natl Acad Sci USA 97: 3400–3405
Anumanthan A, Bensussan A, Boumsell L, Christ AD, Blumberg RS, Voss SD, Patel AT, Robertson MJ, Nadler LM, Freeman GJ (1998) Cloning of BY55, a novel Ig superfamily member expressed on NK cells, CTL, and intestinal intraepithelial lymphocytes. J Immunol 161: 2780–2790
Bieganowska K, Hollsberg P, Buckle GJ, Lim DG, Greten TF, Schneck J, Altman JD, Jacobson S, Ledis SL, Hanchard B, Chin J, Morgan O, Roth PA, Hafler DA (1999) irect analysis of viral-specific CD8+ T cells with soluble HLA-A2/Taxl 1-19 tetramer complexes in patients with human T cell lymphotropic virus-associated myelopathy. J Immunol 162: 1765–1771
Bléry M, Delon J, Trautmann A, Cambiaggi A, Olcese L, Biassoni R, Moretta L, Chavrier P, Moretta A, Daëron M, Vivier E (1997) Reconstituted killer-cell inhibitory receptors for MHC Class I molecules control mast cell activation induced via immunoreceptor tyrosine-based activation motifs. J Biol Chem 272: 8989–8996
Brown MH, Boles K, van der Merwe AP, Kumar V, Mathew PA, Barclay NA (1998) 2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48. J Exp Med 188: 2083–2090
Cambiaggi A, Darche S, Guia S, Kourilsky P, Abastado J P, Vivier E (1999) Modulation of T-cell functions in KIR2DL3 (CD 158b) transgenic mice. Blood 94: 2396–2402
Cambiaggi A, Orengo A M, Meazza R, Sforzini S, Tazzari P L, Lauria F, Raspadori D, Zambello R, Semenzato G, Moretta L, Ferrini S (1996) The natural killer-related receptor for HLA-C expressed on T cells from CD3+ lymphoproliferative disease of granular lymphocytes displays either inhibitory or stimulatory functions. Blood 87: 2369–2375
Cambiaggi A, Verthuy C, Naquet P, Romagne F, Ferner P, Biassoni R, Moretta A, Moretta L, Vivier E (1997) Natural killer cell acceptance of H-2 mismatch bone marrow grafts in transgenic mice expressing HLA-Cw3 specific killer cell inhibitory receptor. Proc Natl Acad Sci USA 94: 8088–8092
Chapman TL, Heikeman AP, Bjorkman PJ (1999) The inhibitory receptor LIR-1 uses a common binding interaction to recognize class I MHC molecules and the viral homolog UL18. Immunity 11: 603–613
Chiu YH, Jayawardena J, Weiss A, Lee D, Park SH, Dautry-Varsat A, Bendelac A (1999) Distinct Subsets of CD Id-restricted T Cells Recognize Self-antigens Loaded in Different Cellular Compartments. J Exp Med 189: 103–110
Coles MC, McMahon CW, Takizawa H, Raulet DH (2000) Memory CD8 T lymphocytes express inhibitory MHC-specific Ly49 receptors. Eur J Immunol 30: 236–244
D’Andrea A, Chang C, Phillips JH, Lanier LL (1996) Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. J Exp Med 184: 789–794
Daëron M, Vivier E (1999) Biology of immunoreceptor tyrosine-based inhibition motif bearing molecules. Curr Top Microbiol Immunol 244: 1–12
Huard B, Karlsson L (2000) KIR expression on self-reactive CD8+ T cells is controlled by T-cell receptor engagement. Nature 403: 325–328
Ikeda H, Lethé B, Lehmann F, Van Baren N, Baurain J-F, De Smet C, Chambost H, Vitale M, Moretta A, Boon T, Coulie PG (1997) Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. Immunity 6: 199–208
Kambayashi T, Assarsson E, Michaëlsson J, Berglund P, Diehl AD, Chambers BJ, Ljunggren H-G (2000) Emergence of CD8+ T cells expressing NK cell receptors in influenza A virus-infected mice. J Immunol 165: 4964–4969
Lanier L L (1998) NK Cell Receptors. Annu Rev Immunol 16: 359–393
Long E O (1999) Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 17: 875–904
Mingari MC, Moretta A, Moretta L (1998) Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses. Immunol Today 19: 153–157
Mingari MC, Ponte M, Cantoni C, Vitale C, Schiavetti F, Bertone S, Bellomo R, Tradori Cappai A, Biassoni R (1997) HLA-class I-specific inhibitory receptors in human cytolytic T lymphocytes: molecular characterization, distribution in lymphoid tissues and co-expression by individual T cells. Int Immunol 9: 485–491
Mingari MC, Schiavetti F, Ponte M, Vitale C, Maggi E, Romagnani S, Demarest J, Pantaleo G, Fauci AS, Moretta L (1996) Human CD8+ T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations. Proc Natl Acad Sci USA 93: 12433–12438
Mingari MC, Vitale C, Cambiaggi A, Schiavetti F, Melioli G, Ferrini S, Poggi A (1995) Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int Immunol 7: 697–703
Moretta L, Biassoni R, Bottino C, Mingari MC, Moretta A (2000) Human NK-cell receptors. Immunol Today 21: 420
Murali-Krishna K, Lau LL, Sambhara S, Lemonnier F, Altman J, Ahmed R (1999) Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice. Science 286: 1377–1381
Norris S, Doherty DG, Collins C, McEntee G, Traynor O, Hegarty JE, O’Farrelly C (1999) Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells. Hum Immunol 60: 20–31
Oehen S, Brduscha-Riem K (1998) Differentiation of naive CTL to effector and memory CTL: correlation of effector function with phenotype and cell division. J Immunol 161: 5338–5346
Ortaldo J, Winkler-Pickett R, Mason AT, Mason LH (1998) The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells. J Immunol 160: 1158–1165
Parrish-Novak J et al. (2000) Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408: 57–63
Phillips JH, Gumperz JE, Parham P, Lanier LL (1995) Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science 268: 403–405
Ravetch JV, Lanier LL (2000) Immune inhibitory receptors. Science 290: 84–89
Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708–712
Speiser DE, Pittet MJ, Valmori D, Dunbar R, Rimoldi D, Lienard D, MacDonald HR, Cerottini JC, Cerundolo V, Romero P (1999) In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. J Exp Med 190: 775–782
Tanchot C, Lemonnier FA, Pérarnau B, Freitas AA, Rocha B (1997) Differential requirements for survival and proliferation of CD8 naïve or memory T cells. Science 276: 2057
Tomasello E, Bléry M, Vély E, Vivier E (2000) Signaling pathways engaged by NK cell receptors: double concerto for activating receptors, inhibitory receptors and NK cells. Semin Immunol 12: 139–147
Tough DF, Sun S, Zhang X, Sprent J (1999) Stimulation of naive and memory T cells by cytokines. Immunol Rev 170: 39–47
Ugolini S, Arpin C, Anfossi N, Walzer T, Cambiaggi A, Forster R, Lipp M, Toes RE, Melief CJ, Marvel J, Vivier E (submitted) Involvement of inhibitory NKR in the survival of Tml cells, a NKR+ subset of memory-phenotype CD8+ T cells.
Vély F, Peyrat M-A, Couedel C, Morcet J-F, Halary F, Davodeau F, Romagne F, Scotet E, Saulquin X, Houssaint E, Schleinitz N, Moretta A, Vivier E, Bonneville M (2001) Regulation of inhibitory and activating Killer-cell-Ig-like receptor (KIR) expression occurs in T cells after termination of TCR rearrangement. J Immunol in press
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Anfossi, N., Pascal, V., Ugolini, S., Vivier, E. (2001). Characterization of Tm1 cells, a NKR+ subset of memory-phenotype CD8+ T cells. In: Cooper, M.D., Takai, T., Ravetch, J.V. (eds) Activating and Inhibitory Immunoglobulin-like Receptors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53940-7_28
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DOI: https://doi.org/10.1007/978-4-431-53940-7_28
Publisher Name: Springer, Tokyo
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