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Autoimmune arthritis and Goodpasture’s syndrome induced in Fcγ receptor-deficient mice

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Activating and Inhibitory Immunoglobulin-like Receptors

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Summary

To address the question whether the type IIB Fc receptor for IgG (FcγRIIB)-deficient mice (RIIB-/-) are susceptible to induction of various autoimmune diseases, we tested to induce type II collagen-induced arthritis (CIA), a model for rheumatoid arthritis in humans. We found that RIIB-/- on a non- permissive H-2b background become susceptible to CIA induction. Moreover, we could induce Goodpasture’s syndrome (GPS) in RIIB-/- by immunization with type IV collagen. Quite similar to human GPS, RIIB-/- develop massive pulmonary hemorrhage and glomerulonephritis. These results highlight the role of FcγRIIB in maintaining tolerance and suggest that it may play a critical role in the pathogenesis of rheumatoid arthritis and GPS in humans.

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Authors and Affiliations

  1. Department of Experimental Immunology and CREST Program of JST, Institute of Development, Aging and Cancer, Tohoku University, Seiryo 4-1, Sendai, 980-8575, Japan

    Toshiyuki Takai & Akira Nakamura

Authors
  1. Toshiyuki Takai
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  2. Akira Nakamura
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Editor information

Editors and Affiliations

  1. Howard Hughes Medical Institute, University of Alabama at Birmingham, 378 Wallace Tumor Institute UAB Station, Birmingham, Alabama, 35294, USA

    Max D. Cooper M.D.

  2. Department of Experimental Immunology, Institute of Development, Aging and Cancer Tohoku University, Seiryo 4-1, Sendai, 980-8575, Japan

    Toshiyuki Takai Ph.D.

  3. Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York, 10021-6399, USA

    Jeffrey V. Ravetch M.D., Ph.D.

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© 2001 Springer Japan

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Takai, T., Nakamura, A. (2001). Autoimmune arthritis and Goodpasture’s syndrome induced in Fcγ receptor-deficient mice. In: Cooper, M.D., Takai, T., Ravetch, J.V. (eds) Activating and Inhibitory Immunoglobulin-like Receptors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53940-7_24

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  • DOI: https://doi.org/10.1007/978-4-431-53940-7_24

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-67959-2

  • Online ISBN: 978-4-431-53940-7

  • eBook Packages: Springer Book Archive

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