Summary
The mouse paired immunoglobulin-like receptors of activating (PIR-A) and inhibitory (PIR-B) types exemplify an emerging family of hematopoietic cell surface receptors whose roles in natural and acquired immunity have yet to be fully elucidated. As implied by their name, coordinate expression of PIR-A and PIR-B is seen on myeloid, dendritic, and B cell lineages. PIR-A and PIR-B share similar ligand-binding extracellular regions composed of six Ig-like domains, but they differ in their signaling potentials on the basis of differences in their transmembrane and cytoplasmic regions. Although PIR-A and PIR-B themselves are not conserved beyond rodents, PIR homologs have been identified in other mammals and birds, suggesting that the PIR genes belong to an ancient ancestral lineage of related Ig-like receptor families. A phylogenetic analysis, employing primary amino acid sequences and three-dimensional protein structures of the PIR homologs and their relatives, suggests a common ancestry for the PIR and Fc receptor families.
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Dennis, G., Chen, CC., Kubagawa, H., Cooper, M.D. (2001). Phylogeny of Paired Ig-like Receptors. In: Cooper, M.D., Takai, T., Ravetch, J.V. (eds) Activating and Inhibitory Immunoglobulin-like Receptors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53940-7_2
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DOI: https://doi.org/10.1007/978-4-431-53940-7_2
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