Summary
Type-I transmembrane glycoprotein, gp49A, is a murine C2-type immunoglobulin-like receptor expressed on the cells involved in natural immunity in parallel with its closely related isotype, gp49B. It has been demonstrated that gp49B contains two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic region, and thereby potentially act as an inhibitory receptor on mast cells and NK cells by associating tyrosine phosphatase activity to phosphorylated ITIMs. On the other hand, as gp49A does not harbor any specific motif for signal transduction, its physiological role has not been determined. Here, we present some novel evidences indicating potential function of gp49A in mast cell activation. Crosslinking of gp49A on rat mast cell line RBL-2H3 evoked cytoplasmic calcium mobilization, prostaglandin D2 (PGD2) release, and transcription of IL-3 and IL-4 genes, but did not elicit exocytosis. Furthermore, activation of gp49-mediated signal required constitutive receptor dimerization and inducible incorporation into glycolipid-enriched membrane fraction (GEM).
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Ono, M., Lee, K.H., Takai, T. (2001). Function of gp49A in mast cell activation. In: Cooper, M.D., Takai, T., Ravetch, J.V. (eds) Activating and Inhibitory Immunoglobulin-like Receptors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53940-7_13
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DOI: https://doi.org/10.1007/978-4-431-53940-7_13
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