Integration of New Neurons into the Adult Hippocampus
The hippocampus is one of the regions where continuous addition of new neurons occurs in adult mammalian brains. In this review, we describe the process of integration of newborn neurons into the neural circuitry of the hippocampus in adult rodents and discuss how hippocampal neurogenesis is regulated by the neural network activity. We further address the functional implications of adult hippocampal neurogenesis in learning and memory.
KeywordsDentate Gyrus Morris Water Maze Enrich Environment Adult Neurogenesis Hippocampal Neurogenesis
Brain lipid-binding protein
Central nervous system
Glial fibrillary acidic protein
Immediate early genes
Morris water maze
Polysialated form of neural cell adhesion molecule
The authors thank Jamie Simon for illustrations and Mary Lynn Gage for helpful comments. This work is supported by National Institutes of Health, Picower Foundation, Lookout Foundation, and J.S. McDonnell Foundations.
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