Fate Specification of Neural Stem Cells
Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along neuronal and glial lineages. At the molecular level, these processes are currently defined in terms of a dynamic interplay between extracellular cues, including cytokine signaling, and intracellular programs such as epigenetic modification, including histone methylation and acetylation and DNA methylation. This review discusses recent advances in our understanding of the molecular mechanisms that control the specification of neuronal, astroglial, and oligodendroglial fates in NSCs of the developing and adult central nervous system.
KeywordsLeukemia Inhibitory Factor Fate Specification Glial Fibrillary Acidic Protein Expression bHLH Protein Oligodendrocyte Differentiation
We thank Dr. Ian Smith for helpful comments and critical reading of the manuscript. We are very grateful to M. Ueda for her excellent secretarial assistance.
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