Neurogenesis in the Adult Rabbit: From Olfactory System to Cerebellum
Adult neurogenesis is a feature that is phylogenetically highly conserved, yet most of the current knowledge in this field is based on laboratory rodents. In addition to the differences among vertebrates, remarkable peculiarities are also emerging in the location and structural and functional features of neurogenic systems in mammals. Although the orders Lagomorpha and Rodentia are quite similar, unexpected features of structural plasticity and neurogenesis have been found to occur in the rabbit central nervous system. The structural and temporal characteristics of protracted and persistent neurogenesis in rabbits are herewith addressed. Attention is focused on the subventricular zone cytoarchitecture and extensions, as well as on processes of persistent neurogenesis that have been recently demonstrated to occur in the striatum and in the cerebellum. The existence of neural cell progenitors persisting within the rabbit brain parenchyma (so-called nonneurogenic in rodents) are discussed.
KeywordsOlfactory Bulb Cerebellar Cortex Stem Cell Niche Neuronal Progenitor Rostral Migratory Stream
This work was supported by Compagnia di San Paolo (Progetto NEUROTRANSPLANT-2004.2019).
- Altman J, Bayer SA (1997) Development of the cerebellar system. CRC Press, Boca Raton, USAGoogle Scholar
- Engelkamp D, Rashbass P, Seawright A, van Heyningen V (1999) Role of Pax6 in development of the cerebellar system. Development 126:3585–3596Google Scholar
- Leto K, Bartolini A, Rossi F (2008) Neurogenesis in the cerebellum of rodents. In: Bonfanti L, ed. Postnatal and Adult Neurogenesis. Research Signpost, Trivandrum, India pp. 63–81Google Scholar
- Yamasaki T, Kawaji K, Ono K et al (2001) Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum. Development 128:3133–3144Google Scholar