Genetic Variants of the Dopaminergic System in Humans and Model Organisms
Human personality is shaped by both genetic and environmental factors. Molecular genetics has begun to identify specific genes for quantitative traits. The first candidate genes investigated were components of the monoamine neurotransmitter pathways, such as serotonin and dopamine. The serotonergic system is involved in mood, anxiety, and aggression. Temperamental predisposition and behavior are likely to be influenced by genetic variations of serotonergic genes – i.e., serotonin-metabolizing enzymes, tryptophan hydroxylase and monoamine oxidase (MAO), catechol-O-methyltransferase (COMT), 14 kinds of serotonin receptor (5-hydroxytryptamine, or 5HT) and serotonin transporter (SERT).
KeywordsAttention Deficit Hyperactivity Disorder Tyrosine Hydroxylase Reverse Transcription Polymerase Chain Reaction Core Promoter bHLH Domain
This work was supported in part by the grants from the Ministry of Health, Labor, and Welfare, Japan, and the Human Frontier Science Program.
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