Extending the Geometrical Design of DNA Nanostructures
Structural DNA nanotechnology enables us to design and fabricate shapes and patterns at nanoscale as a versatile platform for nanotechnology and bio-related computing. Since the introduction of crossover junctions, an endeavor to create nanostructures by DNA are now flourished as self-assemblies of various 2-D and 3-D shapes. Those achievements mainly owe to two factors: one is the geometry defined by crossover junctions, and the other is the introduction of design approach. The design approach itself is not dependent on any junction structure, however the lack of choice in junctions limits the appearance of resultant nanostructures. We found our interconnected single-duplex DNA junction extends the geometry of DNA nanostructures into a broader class of shapes and patterns. Here we propose an abstraction method that enables us to design variety of structures by those junctions with compatibility. Several demonstrations by this abstraction and possibilities of various new shapes and patterns based on the design approach are presented.
KeywordsDouble Helix Minor Groove Geometrical Design Junction Structure Abstraction Method
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