Abstract
GM1 gangliosides accumulate in lysosomes secondary to a deficiency of acid β-galactosidase. The increased GM1 gangliosides in cell membranes cause abnormal neuronal growth and synaptic dysfunction. There is a severe infantile type (with bony and visceral involvement) and milder juvenile and adult types.
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8 Lipidosis
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(2007). Lipidosis. In: Pediatric Neuropathology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-49898-8_8
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DOI: https://doi.org/10.1007/978-4-431-49898-8_8
Publisher Name: Springer, Tokyo
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