Minamata disease (methylmercury poisoning) can affect all ages. In adults all the organs contain increased mercury, but lesions occur mainly in the nervous system, particularly the brain. The neurons, especially nonpyramidal cells in the cerebral and cerebellar cortices, are destroyed. In the cerebrum, there is selective involvement of the calcarine and precentral regions involving neurons in the second and upper third layer and predominantly in the depth of the sulci. In the cerebellum, the granular cells are most susceptible and are lost in the deeper regions of the folia of both hemispheres. In nonfetal infantile Minamata disease there is hypoplasia of various organs, including the brain. There is widespread disintegration of cortical neurons and secondary degeneration of myelin sheaths.
KeywordsCerebellar Cortex Cerebral White Matter Fetal Alcohol Syndrome Drug Intoxication Carbon Monoxide Intoxication
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