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Structural Alterations of Thin Actin Filaments in Muscle Contraction by Synchrotron X-ray Fiber Diffraction

  • Katsuzo Wakabayashi
  • Yasunobu Sugimoto
  • Yasunori Takezawa
  • Yutaka Ueno
  • Shiho Minakata
  • Kanji Oshima
  • Tatsuhito Matsuo
  • Takakazu Kobayashi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 592)

28.1. Abstract

Strong evidence has been accumulated that the conformational changes of the thin actin filaments are occurring and playing an important role in the entire process of muscle contraction. The conformational changes and the mechanical properties of the thin actin filaments we have found by X-ray fiber diffraction on skeletal muscle contraction are explored. Recent studies on the conformational changes of regulatory proteins bound to actin filaments upon activation and in the force generation process are also described. Finally, the roles of structural alterations and dynamics of the actin filaments are discussed in conjunction with the regulation mechanism and the force generation mechanism.

Keywords

Myosin Head Layer Line Actin Monomer Tail Domain Spacing Change 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2007

Authors and Affiliations

  • Katsuzo Wakabayashi
    • 1
  • Yasunobu Sugimoto
    • 1
  • Yasunori Takezawa
    • 1
  • Yutaka Ueno
    • 2
  • Shiho Minakata
    • 4
  • Kanji Oshima
    • 1
  • Tatsuhito Matsuo
    • 1
  • Takakazu Kobayashi
    • 3
  1. 1.Division of Biophysical Engineering, Graduate School of Engineering ScienceOsaka UniversityToyonaka, OsakaJapan
  2. 2.Neuroscience Research InstituteNational Institute of Advanced Science and TechnologyTsukuba, IbarakiJapan
  3. 3.Department of Electronic EngineeringShibaura Institute of TechnologyMinato-ku, TokyoJapan
  4. 4.Harima InstituteThe Institute of Physical and Chemical ResearchKouto, Sayo, HyogoJapan

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