Molecular Pathogenic Mechanisms of Cardiomyopathies Caused by Mutations in Cardiac Troponin T

  • Sachio Morimoto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 592)


Troponin plays a central role in the Ca2+ regulation of contraction in vertebrate skeletal and cardiac muscles. It consists of three subunits with distinct structure and function, troponin T (TnT), troponin I (TnI), and troponin C (TnC), and their accurate and complex intermolecular interaction in response to the rapid rise and fall of Ca2+ in cardiac and skeletal myocytes plays a key role in maintaining the normal cardiac pump function and body movement. Over past decade, a great number of mutations in human genes for the troponin subunits have been shown to cause striated muscle disorders.


Cardiac Muscle Hypertrophic Cardiomyopathy Cardiac Troponin Cardiac Muscle Contraction Nemaline Myopathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer 2007

Authors and Affiliations

  • Sachio Morimoto
    • 1
  1. 1.Department of Clinical PharmacologyKyushu University Graduate School of MedicineFukuokaJapan

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