Immunogenetics of micromammalmacroparasite interactions

  • Nathalie Charbonnel
  • Joelle Goüy de Bellocq
  • Serge Morand

Conclusions and the future

Immunogenetics, the analysis of genetic polymorphisms in specific recognition and immune regulation, is at the core of the study of host-parasite coevolution. Given the well studied laboratory micromammal systems, broad research into micro-mammal immunogenetics now has a firm basis. Unfortunately, most studies continue to focus on MHC genes in lab mouse strains. We crucially lack further investigations considering genetic variation in natural populations, across biogeographical areas or at local scales, and exploring a wider diversity of immune genes. In addition, macroparasite immunogenetics remains scarcely explored, even though it is a topic of major importance to evaluate the effects of host immune gene diversity, from both specificity and regulation aspects, on antigenic variation. Such information will provide significant insights into the processes of adaptation at the molecular levels in these host-parasite systems. It will also provide the basis for future promising research areas including experimental evolution, which still mainly concerns viruses, and is essential to determine the nature of selection acting on the host or parasite immune genes or to reconcile the hypotheses of coevolution and genetic trade-offs.


Major Histocompatibility Complex Major Histocompatibility Complex Class Major Histocompatibility Complex Gene Transporter Associate With Antigen Processing Major Histocompatibility Complex Allele 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Tokyo 2006

Authors and Affiliations

  • Nathalie Charbonnel
  • Joelle Goüy de Bellocq
  • Serge Morand

There are no affiliations available

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