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OPLL pp 49-57 | Cite as

Pathology of Ossification of the Ligamentum Flavum

  • Munehito Yoshida

Conclusions

Microscopic findings in OLF specimens showed an overgrowth of type II collagen preceding the development of ossification. There was also a reduction in the amount of elastin. OLF was confirmed to be mainly endochondral ossification. Additional intramembranous ossification was, however, seen at the tip of the nodule-shaped ossification. Ossification extended along the superficial layer of the hypertrophied ligament, as in OPLL. It was suggested that the mechanism of OLF development depends intimately not only on dynamic and static mechanical stresses but also on the role of some growth factors as well.

Keywords

Spinal Canal Thoracic Spine Posterior Longitudinal Ligament Diffuse Idiopathic Skeletal Hyperostosis Cartilage Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2006

Authors and Affiliations

  • Munehito Yoshida
    • 1
  1. 1.Department of Orthopaedic SurgeryWakayama Medical UniversityWakayama City, WakayamaJapan

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