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OPLL pp 7-9 | Cite as

Overview of Epidemiology and Genetics

  • Shunji Matsunaga
  • Takashi Sakou

Keywords

Cervical Spine Posterior Longitudinal Ligament Cervical Myelopathy Diffuse Idiopathic Skeletal Hyperostosis Spinal Ligament 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Key CA (1838) On paraplegia depending on the ligaments of the spine. Guys Hosp Rep 3:17–34Google Scholar
  2. 2.
    Tsukimoto H (1960) A case report-autopsy of syndrome of compression of spinal cord owing to ossification within spinal canal of cervical spines. Arch Jpn Chir 29:1003–1007 (in Japanese)Google Scholar
  3. 3.
    Onji Y, Akiyama H, Shimomura Y, Ono K, Fukuda S, Mizuno S (1967) Posterior paravertebral ossification causing cervical myelopathy: a report of eighteen cases. J Bone Joint Surg Am 49:1314–1328PubMedGoogle Scholar
  4. 4.
    Minagi H, Gronner AT (1969) Calcification of the posterior longitudinal ligament: a cause of cervical myelopathy. Am J Roentgenol Radium Ther Nucl Med 105:365–369PubMedGoogle Scholar
  5. 5.
    Nagashima C (1972) Cervical myelopathy due to ossification of the posterior longitudinal ligament. J Neurosurg 37:653–660PubMedCrossRefGoogle Scholar
  6. 6.
    Terayama K, Maruyama S, Miyashita R, Yakubukuro K, Kinoshita M, Shimizu Y, Mochizuki I (1964) Ossification of the posterior longitudinal ligament in the cervical spine. Seikeigeka 15:1083–1095 (in Japanese)Google Scholar
  7. 7.
    Resnick D, Niwayama G (1976) Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 119:559–568PubMedGoogle Scholar
  8. 8.
    Breidahl P (1969) Ossification of the posterior longitudinal ligament of the spine. “The Japanese disease” occurring in patients of British descent. Aust Radiol 13:311–313Google Scholar
  9. 9.
    Dietemann JL, Dirheimer Y, Babin E, Edel L, Dosch JC, Hirsch E, Wackenheim A (1985) Ossification of the posterior longitudinal ligament (Japanese disease): a radiological study in 12 cases. J Neuroradiol 12:212–222PubMedGoogle Scholar
  10. 10.
    Sakou T, Matsunaga S (1996) Ossification of the posterior longitudinal ligament. J Jpn Spine Res Soc 7:437–448 (in Japanese)Google Scholar
  11. 11.
    Liu K (1990) Epidemiological study on ossification of the posterior longitudinal ligament (OPLL) in the cervical spine: comparison of prevalence between Japanese and Taiwanese. J Jpn Orthop Assoc 64:401–408 (in Japanese)Google Scholar
  12. 12.
    Tomita T, Harata S, Ueyama K, Araki T, Ito J, Sato T, Sannohe A, Tian W, Yamada S, Sonoda S, Rong G, Jia Y, Dang GT, Cai Q, Liu S (1994) Epidemiological study of ossification of the posterior longitudinal ligament (OPLL) of cervical spine and cervical spondylotic changes in China. Investigation Committee 1993 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 101–105 (in Japanese)Google Scholar
  13. 13.
    Izawa K (1980) Comparative radiographic study on the incidence of ossification of the cervical spine among Japanese, Koreans, Americans, and Germans. J Jpn Orthop Assoc 54:461–474 (in Japanese)Google Scholar
  14. 14.
    Terayama K, Ohtsuka K (1984) Epidemiological study of OPLL in Bologna, Italy. Investigation Committee 1983 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 55–62 (in Japanese)Google Scholar
  15. 15.
    Kurokawa T (1978) Prevalence of ossification of the posterior longitudinal ligament of the cervical spine in Taiwan, Hong Kong, and Singapore. Investigation Committee 1977 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 26–27 (in Japanese)Google Scholar
  16. 16.
    Terayama K, Kurokawa T, Seki H (1976) National survey of ossification of the posterior longitudinal ligament. Investigation Committee 1975 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 8–33 (in Japanese)Google Scholar
  17. 17.
    Ohtsuka K, Terayama K, Yanagihara M, Wada K, Kasuga K, Machida T, Matsushima S (1987) A radiological population study on the ossification of the posterior longitudinal ligament in the spine. Arch Orthop Trauma Surg 1987;106:89–93CrossRefGoogle Scholar
  18. 18.
    Tomita T, Harata S, Ueyama K, Araki T, Ito J, Sato T, Sannohe A, Tian W, Yamada S, Sonoda S, Rong G, Jia Y, Dang GT, Cai Q, Liu S (1994) Epidemiological study of ossification of the posterior longitudinal ligament (OPLL) of cervical spine and cervical spondylotic changes in China. Investigation Committee 1993 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 101–105 (in Japanese)Google Scholar
  19. 19.
    Sasaki R, Aoki K, Mizuno S, Asano A, Katsuta N, Terayama K, Ohtsuka Y (1986) National survey of ossification of the spinal ligament. Investigation Committee 1985 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 43–48 (in Japanese)Google Scholar
  20. 20.
    Terayama K (1989) Genetic studies on ossification of the posterior longitudinal ligament of the spine. Spine 14:1184–1191PubMedCrossRefGoogle Scholar
  21. 21.
    Miura Y, Kawai K (1993) Genetic studies of OPLL: analysis of twins. Seikeigeka 44:993–998 (in Japanese)Google Scholar
  22. 22.
    Sakou T, Taketomi E, Matsunaga S, Yamaguchi M, Sonoda S, Yashiki S (1991) Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype. Spine 16:1249–1252PubMedCrossRefGoogle Scholar
  23. 23.
    Sugawara O, Suematsu N, Naka T (1990) Ossification of the posterior longitudinal ligament of the cervical spine and HLA. Bessatu Seikeigaka 18:186–189 (in Japanese)Google Scholar
  24. 24.
    Koga H, Sakou T, Taketomi E, Hayashi K, Numasawa T, Harata S, Yone K, Matsunaga S, Otterud B, Inoue I (1998) Genetic mapping of ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet 62:1460–1467PubMedCrossRefGoogle Scholar
  25. 25.
    Nakamura I, Ikegawa S, Okawa A, Okuda S, Koshizuka Y, Kawaguchi H, Nakamura K, Koyama T, Goto S, Toguchida J, Matsushita M, Ochi T, Takaoka K, Nakamura Y (1999) Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Hum Genet 104:492–497PubMedCrossRefGoogle Scholar
  26. 26.
    Tanaka T, Ikari K, Furushima K, Okada A, Tanaka H, Furukawa K, Yoshida K, Ikeda T, Ikegawa S, Hunt SC, Takeda J, Toh S, Harata S, Nakajima T, Inoue I (2003) Genomewide linkage and linkage disequilibrium analyses identify COL6A1 on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet 73:812–822PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  • Shunji Matsunaga
    • 1
  • Takashi Sakou
    • 2
  1. 1.Department of Orthopaedic SurgeryGraduate School of Medical and Dental SciencesKagoshimaJapan
  2. 2.Sakou Orthopaedic ClinicKagoshimaJapan

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