Skip to main content
SpringerLink
Log in

Overview of Epidemiology and Genetics

  • Chapter
Book cover OPLL

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Key CA (1838) On paraplegia depending on the ligaments of the spine. Guys Hosp Rep 3:17–34

    Google Scholar 

  2. Tsukimoto H (1960) A case report-autopsy of syndrome of compression of spinal cord owing to ossification within spinal canal of cervical spines. Arch Jpn Chir 29:1003–1007 (in Japanese)

    Google Scholar 

  3. Onji Y, Akiyama H, Shimomura Y, Ono K, Fukuda S, Mizuno S (1967) Posterior paravertebral ossification causing cervical myelopathy: a report of eighteen cases. J Bone Joint Surg Am 49:1314–1328

    PubMed  CAS  Google Scholar 

  4. Minagi H, Gronner AT (1969) Calcification of the posterior longitudinal ligament: a cause of cervical myelopathy. Am J Roentgenol Radium Ther Nucl Med 105:365–369

    PubMed  CAS  Google Scholar 

  5. Nagashima C (1972) Cervical myelopathy due to ossification of the posterior longitudinal ligament. J Neurosurg 37:653–660

    Article  PubMed  CAS  Google Scholar 

  6. Terayama K, Maruyama S, Miyashita R, Yakubukuro K, Kinoshita M, Shimizu Y, Mochizuki I (1964) Ossification of the posterior longitudinal ligament in the cervical spine. Seikeigeka 15:1083–1095 (in Japanese)

    Google Scholar 

  7. Resnick D, Niwayama G (1976) Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology 119:559–568

    PubMed  CAS  Google Scholar 

  8. Breidahl P (1969) Ossification of the posterior longitudinal ligament of the spine. “The Japanese disease” occurring in patients of British descent. Aust Radiol 13:311–313

    CAS  Google Scholar 

  9. Dietemann JL, Dirheimer Y, Babin E, Edel L, Dosch JC, Hirsch E, Wackenheim A (1985) Ossification of the posterior longitudinal ligament (Japanese disease): a radiological study in 12 cases. J Neuroradiol 12:212–222

    PubMed  CAS  Google Scholar 

  10. Sakou T, Matsunaga S (1996) Ossification of the posterior longitudinal ligament. J Jpn Spine Res Soc 7:437–448 (in Japanese)

    Google Scholar 

  11. Liu K (1990) Epidemiological study on ossification of the posterior longitudinal ligament (OPLL) in the cervical spine: comparison of prevalence between Japanese and Taiwanese. J Jpn Orthop Assoc 64:401–408 (in Japanese)

    CAS  Google Scholar 

  12. Tomita T, Harata S, Ueyama K, Araki T, Ito J, Sato T, Sannohe A, Tian W, Yamada S, Sonoda S, Rong G, Jia Y, Dang GT, Cai Q, Liu S (1994) Epidemiological study of ossification of the posterior longitudinal ligament (OPLL) of cervical spine and cervical spondylotic changes in China. Investigation Committee 1993 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 101–105 (in Japanese)

    Google Scholar 

  13. Izawa K (1980) Comparative radiographic study on the incidence of ossification of the cervical spine among Japanese, Koreans, Americans, and Germans. J Jpn Orthop Assoc 54:461–474 (in Japanese)

    CAS  Google Scholar 

  14. Terayama K, Ohtsuka K (1984) Epidemiological study of OPLL in Bologna, Italy. Investigation Committee 1983 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 55–62 (in Japanese)

    Google Scholar 

  15. Kurokawa T (1978) Prevalence of ossification of the posterior longitudinal ligament of the cervical spine in Taiwan, Hong Kong, and Singapore. Investigation Committee 1977 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 26–27 (in Japanese)

    Google Scholar 

  16. Terayama K, Kurokawa T, Seki H (1976) National survey of ossification of the posterior longitudinal ligament. Investigation Committee 1975 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 8–33 (in Japanese)

    Google Scholar 

  17. Ohtsuka K, Terayama K, Yanagihara M, Wada K, Kasuga K, Machida T, Matsushima S (1987) A radiological population study on the ossification of the posterior longitudinal ligament in the spine. Arch Orthop Trauma Surg 1987;106:89–93

    Article  CAS  Google Scholar 

  18. Tomita T, Harata S, Ueyama K, Araki T, Ito J, Sato T, Sannohe A, Tian W, Yamada S, Sonoda S, Rong G, Jia Y, Dang GT, Cai Q, Liu S (1994) Epidemiological study of ossification of the posterior longitudinal ligament (OPLL) of cervical spine and cervical spondylotic changes in China. Investigation Committee 1993 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 101–105 (in Japanese)

    Google Scholar 

  19. Sasaki R, Aoki K, Mizuno S, Asano A, Katsuta N, Terayama K, Ohtsuka Y (1986) National survey of ossification of the spinal ligament. Investigation Committee 1985 report on the ossification of the spinal ligaments of the Japanese Ministry of Public Health and Welfare, pp 43–48 (in Japanese)

    Google Scholar 

  20. Terayama K (1989) Genetic studies on ossification of the posterior longitudinal ligament of the spine. Spine 14:1184–1191

    Article  PubMed  CAS  Google Scholar 

  21. Miura Y, Kawai K (1993) Genetic studies of OPLL: analysis of twins. Seikeigeka 44:993–998 (in Japanese)

    Google Scholar 

  22. Sakou T, Taketomi E, Matsunaga S, Yamaguchi M, Sonoda S, Yashiki S (1991) Genetic study of ossification of the posterior longitudinal ligament in the cervical spine with human leukocyte antigen haplotype. Spine 16:1249–1252

    Article  PubMed  CAS  Google Scholar 

  23. Sugawara O, Suematsu N, Naka T (1990) Ossification of the posterior longitudinal ligament of the cervical spine and HLA. Bessatu Seikeigaka 18:186–189 (in Japanese)

    Google Scholar 

  24. Koga H, Sakou T, Taketomi E, Hayashi K, Numasawa T, Harata S, Yone K, Matsunaga S, Otterud B, Inoue I (1998) Genetic mapping of ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet 62:1460–1467

    Article  PubMed  CAS  Google Scholar 

  25. Nakamura I, Ikegawa S, Okawa A, Okuda S, Koshizuka Y, Kawaguchi H, Nakamura K, Koyama T, Goto S, Toguchida J, Matsushita M, Ochi T, Takaoka K, Nakamura Y (1999) Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Hum Genet 104:492–497

    Article  PubMed  CAS  Google Scholar 

  26. Tanaka T, Ikari K, Furushima K, Okada A, Tanaka H, Furukawa K, Yoshida K, Ikeda T, Ikegawa S, Hunt SC, Takeda J, Toh S, Harata S, Nakajima T, Inoue I (2003) Genomewide linkage and linkage disequilibrium analyses identify COL6A1 on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet 73:812–822

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Orthopaedic Surgery, Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, 890-8520, Japan

    Shunji Matsunaga

  2. Sakou Orthopaedic Clinic, 1-30 Yamanokuchi, Kagoshima, 892-0844, Japan

    Takashi Sakou

Authors
  1. Shunji Matsunaga
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takashi Sakou
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. National Hospital Organization, Osaka-Minami Medical Center, 2-1 Kidohigashi, Kawachinagano, Osaka, 586-8521, Japan

    Kazuo Yonenobu M.D., D.Med.Sc. (Vice-Director) (Vice-Director)

  2. Department of Orthopaedic Surgery Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Kozo Nakamura M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  3. Department of Orthopedic Surgery School of Medicine, Keio University 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Yoshiaki Toyama M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer

About this chapter

Cite this chapter

Matsunaga, S., Sakou, T. (2006). Overview of Epidemiology and Genetics. In: Yonenobu, K., Nakamura, K., Toyama, Y. (eds) OPLL. Springer, Tokyo. https://doi.org/10.1007/978-4-431-32563-5_2

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-32563-5_2

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-32561-1

  • Online ISBN: 978-4-431-32563-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation