Nuclear Architecture: Topology and Function of Chromatin- and Non-Chromatin Nuclear Domains

  • Satoshi Tashiro
  • Marion Cremer
  • Irina Solovei
  • Thomas Cremer


The driving force behind studies on nuclear architecture is based on the assumption that nuclear architecture is an integrated part of the complex epigenetic regulatory mechanisms which control cell type specific gene expression patterns. Epigenetic mechanisms comprise the chromatin level, including DNA methylation, histone modifications and chromatin remodeling factors, and the nuclear level, which includes the dynamics and three-dimensional (3D) spatial higher-order organization of the genome inside the cell nucleus. There is increasing evidence that such a higher-order organization of chromatin arrangement contributes essentially to the regulation of gene expression and other nuclear functions (for review see Spector 2003; van Driel et al. 2003).


Fluorescence Recovery After Photobleaching Chromatin Domain Chromosome Territory Cajal Body Nijmegen Breakage Syndrome 
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Copyright information

© Springer 2007

Authors and Affiliations

  • Satoshi Tashiro
    • 1
  • Marion Cremer
    • 2
  • Irina Solovei
    • 2
  • Thomas Cremer
    • 2
  1. 1.Department of Cellular Biology, Research Institute for Radiation Biology and medicineHiroshima UniversityHiroshimaJapan
  2. 2.Department of Biology IILudwig Maximilians University (LMU)MartinsriedGermany

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