Functional Organization and Dynamic Aspects of Nucleoli During the Cell Cycle
The nucleolus is the most prominent structure in the nucleus, and is clearly distinguished from other nuclear substructures (Scheer and Hock 1999; Olson et al. 2000; Spector 2003). Since the 1960s, it has been generally thought to be the site of ribosome biogenesis. Inner nucleolar DNA sequences encode 18S, 5.8S and 28S ribosomal RNAs and in the nucleolus, many ribosomal proteins and nascent ribosomes are detected (Fatica and Tollervey 2002; Raska 2003). In metabolically active animal and plant somatic cells and in yeast, the nucleolus harbors tens to hundreds of active ribosomal genes, which account for roughly one half of the total cellular RNA production, while no other types of active genes have been identified within it.
KeywordsNucleolar Protein Curr Opin Cell Biol rRNA Processing Granular Component Dense Fibrillar Component
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