Breaking and Tessellating the Contiguous Nuclear Genome
“Preformation” and “epigenesis” were the two antithetical concepts theoretical biologists of the early 18th century advocated to explain ontogenesis. Apparently their repercussions still remain and keep vibrating, at least in a subject of the current biological study; i.e. how the usage of “genetic” information, an ultimate “preformed” material, is controlled by the “epigenetics,” a derivative of “epigenesis,” and conversely, how such “epigenetic” regulations are restricted by the cisacting “genetic” elements. The genetic elements described in the latter issue are experimentally defined as “boundary elements” or “insulators,” and have been studied extensively for decades (Gerasimova and Corces 2001). Here I am going to summarize some of the recent advances to unravel the mechanics of boundary elements that hinder spread of epigenetic heterochromatin. They appear to be classified functionally into two groups, the antagonistic chromosomal effect and the structural tethering in the nucleus.
KeywordsBoundary Element Nuclear Pore Complex Chromatin Domain Histone Variant Chromatin Fiber
Unable to display preview. Download preview PDF.
- Krogan NJ, Keogh MC, Datta N, Sawa C, Ryan OW, Ding H, Haw RA, Pootoolal J, Tong A, Canadien V, Richards DP, Wu X, Emili A, Hughes TR, Bura-towski S, Greenblatt JF (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12:1565–1576PubMedCrossRefGoogle Scholar