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Regulation of Chromatin Structure by Curved DNA: How Activator Binding Sites Become Accessible

  • Takashi Ohyama

Abstract

A single somatic cell of humans contains DNA fibers of a total length of approximately 2 m, which are compacted, without entanglement, into the nucleus of approximately 1×10−5 m in diameter. To greater or lesser degrees, all organisms compact their DNA. Biologically important DNA regions, such as the origins of DNA replication, regulatory regions of transcription, and recombination loci, must all be compacted. The tightly constrained DNA, however, presents the appropriate environment for replication, transcription, and recombination to take place.

Keywords

Mouse Mammary Tumor Virus Nucleosome Assembly Histone Octamers Nucleosome Formation Local Chromatin Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2007

Authors and Affiliations

  • Takashi Ohyama
    • 1
  1. 1.Department of Biology, Faculty of Education and Integrated Arts and Sciences, Major in Integrative Bioscience and Biomedical Engineering, Graduate School of Science and EngineeringWaseda UniversityTokyoJapan

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