IMS as an Historical Innovation
The development of mass spectrometry has recently entered a new phase. The previous limitation of mass analyses of biomolecules confined the imagination of researchers to a single location from which samples were gathered; however, an innovation in mass spectrometry has now enabled the provision of additional two-dimensional (2D) axes of recognition on tissue sections. The innovatory technology — imaging mass spectrometry — can visualize the distribution of molecules. It has attracted a great deal of attention in the analyses of drug effects, in screening of drugs, and in support for medical diagnoses. In this chapter, we describe imaging mass spectrometry as an historical innovation and the significance of publishing this protocol book. I strongly believe that this book provides a critical basis for future studies on imaging mass spectrometry.
KeywordsImage Mass Spectrometry Metabolomic Analysis Desorption Electrospray Ionization MALDI Imaging DESI Imaging
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Shimma S, Setou M (2005) Review of imaging mass spectrometry. J Mass Spectrom Soc Jpn 53:230–238CrossRefGoogle Scholar
Caprioli RM, Farmer TB, Gile J (1997) Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal Chem 69(23):4751–4760PubMedCrossRefGoogle Scholar
Takáts Z, Wiseman JM, Gologan B, Cooks RG (2004) Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 306:471–473PubMedCrossRefGoogle Scholar
Maarten Altelaar AF, Taban IM, McDonnell LA, et al. (2007) High-resolution MALDI imaging mass spectrometry allows localization of peptide distributions at cellular length scales in pituitary tissue sections. Int J Mass Spectrom 260:203–211CrossRefGoogle Scholar
Taira S, Sugiura Y, Moritake S, et al. (2008) Nanoparticle-assisted laser desorption/ionization based mass imaging with cellular resolution. Anal Chem 80(12):4761–4766PubMedCrossRefGoogle Scholar
Shimma S, Setou M (2007) Mass microscopy revealed the distinct localization of heme B(m/z 616) in colon cancer liver metastasis. J Mass Spectrom Soc Jpn 55:145–148CrossRefGoogle Scholar
Shimma S, Sugiura Y, Hayasaka T, et al. (2007) MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis. J Chromatogr B Anal Technol Biomed Life Sci 855:98–103CrossRefGoogle Scholar