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Neuropsychiatrische Funktion und Pathologie des NMDA-Rezeptors

  • Conference paper
Universitätskolloquien zur Schizophrenie

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Zusammenfassung

In einem kurzen Überblick sollen Informationen über die neuropsychiatrische Funktion und die Pathologie des N-methyl-D-aspartat (NMDA)-Rezeptors vermittelt werden. Schwerpunkte sind sowohl neurobiologische als auch psychopathologische Aspekte unter besonderer Berücksichtigung der Schizophrenie.

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Literatur

  1. Baxter MG, Lanthorn TH, Frick KM, Golski S, Wan RQ, Olton DS (1994) D-cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats. Neurobiol Aging 15:207–13

    Article  PubMed  CAS  Google Scholar 

  2. Cui Z, Wang H, Tan Y, Zaia KA, Zhang S, Tsien JZ (2004) Inducible and reversible NR1 knock-out reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Neuron 41: 781–93

    Article  PubMed  CAS  Google Scholar 

  3. Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M (2003) Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sei USA 100:4855–4860. Epub 2003 Apr 3

    Article  CAS  Google Scholar 

  4. Goff DC, Tsai G, Levitt J, Amico E, Manoach D, Schoenfeld DA, Hayden DL, McCarley R, Coyle JT (1999) A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Arch Gen Psychiatry 56:21–27

    Article  PubMed  CAS  Google Scholar 

  5. Grimwood S, Slater P, Deakin JF, Hutson PH (1999) NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia. Neuroreport 10:461–465

    Article  PubMed  CAS  Google Scholar 

  6. Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Silipo G, Lichtenstein M (1999) Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia, Arch Gen Psychiatry 56: 29–36

    Article  PubMed  CAS  Google Scholar 

  7. Matthews DB, Morrow AL (2000) Effects of acute and chronic ethanol exposure on spatial cognitive processing and hippocampal function in the rat. Hippocampus 10:122–130

    Article  PubMed  CAS  Google Scholar 

  8. McCardle K, Luebbers S, Carter JD, Croft RJ, Stough C (2004) Chronic MDMA (ecstasy) use, cognition and mood. Psychopharmacology 16:16

    Google Scholar 

  9. Moyano S, Frechilla D, Del Rio J (2004) NMDA receptor subunit and CaMKII changes in rat hippocampus induced by acute MDMA treatment: a mechanism for learning impairment, Psychopharmacology 25: 25

    Google Scholar 

  10. Newcomer JW, Farber NB, Jevtovic-Todorovic V, Selke G, Melson AK, Hershey T, Craft S, Olney JW (1999) Ketamine-induced NMDA receptor hypofunction as a model of memory impairment and psychosis. Neuropsychopharmacology 20:106–118

    Article  PubMed  CAS  Google Scholar 

  11. Olney JW, Farber NB (1995) Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52: 998–1007

    Article  PubMed  CAS  Google Scholar 

  12. Olney JW, Newcomer JW, Farber NB (1999) NMDA receptor hypofunction model of schizophrenia. J Psychiatr Res 33: 523–533

    Article  PubMed  CAS  Google Scholar 

  13. Philpot BD, Weisberg MP, Ramos MS, Sawtell NB, Tang YP, Tsien JZ, Bear MF (2001) Effect of transgenic overexpression of NR2B on NMDA receptor function and synaptic plasticity in visual cortex. Neuropharmacology 41: 762–770

    Article  PubMed  CAS  Google Scholar 

  14. Scheuer K, Rostock A, Bartsch R, Muller WE (1999) Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain. Pharmacopsychiatry, 32(Suppl 1): 10–16

    Article  PubMed  CAS  Google Scholar 

  15. Schiffelholz T, Hinze-Selch D, Aldenhoff JB (2004) Perinatal MK-801 treatment affects age-related changes in locomotor activity from childhood to later adulthood in rats. Neurosci Lett, 360:157–160

    Article  PubMed  CAS  Google Scholar 

  16. Sprengel R, Suchanek B, Amico C, Brusa R, Burnashev N, Rozov A, Hvalby O, Jensen V, Paulsen O, Andersen P, Kim JJ, Thompson RF, Sun W, Webster LC, Grant SG, Eilers J, Konnerth A, Li J, McNamara JO, Seeburg PH (1998) Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 92:279–289

    Article  PubMed  CAS  Google Scholar 

  17. Tiihonen J, Hallikainen T, Ryynanen OP, Repo-Tiihonen E, Kotilainen I, Eronen M, Toivonen P, Wahlbeck K, Putkonen A (2003) Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial. Biol Psychiatry 54:1241–1248

    Article  PubMed  CAS  Google Scholar 

  18. Tsai G, Yang P, Chung LC, Lange N, Coyle JT (1998) D-serine added to antipsychotics for the treatment of schizophrenia. Biol Psychiatry 44:1081–1089

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. T. Schiffelholz
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Editors and Affiliations

  1. Klinik für Psychiatrie und Psychotherapie, Ludwig-Maximilians-Universität München, Nußbaumstr. 7, 80336, München

    Hanns Hippius (em. o. Professor für Psychiatrie) (em. o. Professor für Psychiatrie)

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© 2004 Springer-Verlag Berlin Heidelberg

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Schiffelholz, T. (2004). Neuropsychiatrische Funktion und Pathologie des NMDA-Rezeptors. In: Hippius, H. (eds) Universitätskolloquien zur Schizophrenie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-7985-1957-2_26

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  • DOI: https://doi.org/10.1007/978-3-7985-1957-2_26

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-62369-1

  • Online ISBN: 978-3-7985-1957-2

  • eBook Packages: Springer Book Archive

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