Controversies in schizophrenia research: the ‘continuum’ challenge, heterogeneity vs homogeneity, and lifetime developmental-‘neuroprogressive’ trajectory

  • Patrizia A. Baldwin
  • Robin J. Hennessy
  • Maria G. Morgan
  • John F. Quinn
  • Paul J. Scully
  • John L. Waddington


In reviewing the extent to which our understanding has advanced between the 4thand 5thsymposia on Search for the Causes of Schizophrenia, the conclusion is salutary: a committed and expanding research community, able to apply an increasing armamentarium of molecular genetic, neuropathological, neuroimaging and additional techniques, has made only modest gains over this five-year period. In the face of such a slow (though not negligible) rate of progress, it is necessary to give further consideration to some of the premises which guide current thinking, as they may be impeding rather than facilitating these endeavours.


Bipolar Disorder Schizoaffective Disorder Psychotic Illness Directional Asymmetry Neurological Soft Sign 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Patrizia A. Baldwin
    • 1
    • 2
  • Robin J. Hennessy
    • 1
    • 2
  • Maria G. Morgan
    • 1
    • 2
  • John F. Quinn
    • 1
    • 2
  • Paul J. Scully
    • 1
    • 2
  • John L. Waddington
    • 1
    • 2
  1. 1.Department of Clinical PharmacologyRoyal College of Surgeons in IrelandDublin 2Ireland
  2. 2.Stanley Research UnitMonaghanIreland

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