Schizophrenia: developmental, degenerative or both?
The fundamental cause or causes of schizophrenia are unknown in a majority of cases. As accepted by most neurologists, developmental disorders include a diversity of developmental malformations and diseases acquired during the intrauterine period of life (Adams and Victor 1977). In contrast degenerative disorders include “an inexplicable decline from a previous level of normalcy to a lower level of function” (Adams and Victor 1977). A change in our understanding of the etiology of many genetic, metabolic, toxic, and nutritional disorders has changed the definition of some disorders formerly deemed degenerative to one or more of these designations. What about schizophrenia? Clinical and pharmacological data suggest that schizophrenia results from an imbalance between specific excitatory and inhibitory systems in specific brain regions that occurs most frequently but not exclusively during adolescence and young adult life (Stevens 2002).
KeywordsBasal Forebrain Ventral Striatum Septal Area Diagonal Band BioI Psychiatry
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