Genetics of schizophrenia and the impact of neuropsychology
As evidenced by a bulk 0of twin and family studies schizophrenia is clearly a genetically influenced disorder, with more than 50% of the etiological variance being due to genetic variation. This genetic diathesis has to be considered together with the preferential onset of the disorder in late adolescence and early adulthood, and the severe associated disability and impairment. On this basis a decline of prevalence over time in all populations has been proposed but not observed; this constellation is called the “paradox of schizophrenia”.
KeywordsSusceptibility Gene Candidate Region Verbal Ability Cognitive Correlate BDNF Val66met
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