Genetics of schizophrenia and the impact of neuropsychology

  • W. Maier
  • M. Wagner
  • P. Falkai
  • S. G. Schwab
Conference paper


As evidenced by a bulk 0of twin and family studies schizophrenia is clearly a genetically influenced disorder, with more than 50% of the etiological variance being due to genetic variation. This genetic diathesis has to be considered together with the preferential onset of the disorder in late adolescence and early adulthood, and the severe associated disability and impairment. On this basis a decline of prevalence over time in all populations has been proposed but not observed; this constellation is called the “paradox of schizophrenia”.


Susceptibility Gene Candidate Region Verbal Ability Cognitive Correlate BDNF Val66met 
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  1. Badner JA, Gershon ES (2002) Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 7:405–411PubMedCrossRefGoogle Scholar
  2. Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D, Finkelstein J, Hietanen M, Kaprio J, Koskenvuo M (2000) The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet 67:369–382PubMedCrossRefGoogle Scholar
  3. Crow TJ (1995) A Darwinian approach to the origins of psychosis. Br J Psychiatry 167:12–25PubMedCrossRefGoogle Scholar
  4. DeLisi LE, Craddock NJ, Detera-Wadleigh S, Foroud T, Gejman P, Kennedy JL, Lendon C, Macciardi F, McKeon P, Mynett-Johnson L, Nurnberger JI jr, Paterson A, Schwab S, Van Broeckhoven C, Wildenauer D, Crow TJ (2000) Update on chromosomal locations for psychiatric disorders: report of the interim meeting of chromosome workshop chairpersons from the VIIth World Congress of Psychiatric Genetics, Monterey, California, October 14–18, 1999. Am J Med Genet 96:434–449PubMedCrossRefGoogle Scholar
  5. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR (2001) Effect of COMT Va1108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 98:6917–6922PubMedCrossRefGoogle Scholar
  6. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257–269PubMedCrossRefGoogle Scholar
  7. Faraone SV, Seidman LJ, Kremen WS, Pepple JR, Lyons MJ, Tsuang MT (1995) Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J Abnorm Psychol 104:286–304PubMedCrossRefGoogle Scholar
  8. Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645PubMedCrossRefGoogle Scholar
  9. Harrison PJ, Owen MJ (2003) Genes for schizophrenia? Recent findings and their pathophysiological implications. Lancet 361:417–419PubMedCrossRefGoogle Scholar
  10. Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES (2003) Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet 72:1131–1140PubMedCrossRefGoogle Scholar
  11. Heinrichs RW, Zakzanis KK (1998) Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12:426–445PubMedCrossRefGoogle Scholar
  12. Levinson DF, Holmans P, Straub RE, Owen MJ, Wildenauer DB, Gejman PV, Pulver AE, Laurent C, Kendler KS, Walsh D, Norton N, Williams NM, Schwab SG, Lerer B, Mowry BJ, Sanders AR, Antonarakis SE, Blouin JL, DeLeuze JF, Mallet J (2000) Multicenter linkage study of schizophrenia candidate regions on chromosomes 5q, 6q, 10p, and 13q: schizophrenia linkage collaborative group III. Am J Hum Genet 67:652–663PubMedCrossRefGoogle Scholar
  13. Tsuang MT, Stone WS, Tarbox SI, Faraone SV (2002) An integration of schizophrenia with schizotypy: identification of schizotaxia and implications for research on treatment and prevention. Schizophr Res 54:169–175PubMedCrossRefGoogle Scholar
  14. Wagner M, Frommann I, Schröder C, Matuschek E, Pukrop R (2002) Neurocognitive performance in presumed prodromal stages of schizophrenia. Schizophr Res 53 (Suppl 3):35–36Google Scholar
  15. Wexler BE, Donegan N, Stevens AA, Jacob SA (2002) Deficits in language-mediated mental operations in patients with schizophrenia. Schizophr Res 53:171–179PubMedCrossRefGoogle Scholar
  16. Wright AF, Carothers AD, Pirastu M (1999) Population choice in mapping genes for complex diseases. Nat Genet 23:397–404PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • W. Maier
    • 1
  • M. Wagner
    • 1
  • P. Falkai
    • 2
  • S. G. Schwab
    • 1
  1. 1.Department of PsychiatryUniversity of BonnBonnGermany
  2. 2.Department of PsychiatrySaarland UniversityHomburgGermany

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