Searching for inherited causes for schizophrenia: has progress been made?
This book currently outlines the conclusions drawn subsequent to the 5thconvening of investigators on “Search for the Causes of Schizophrenia”. In all previous such volumes, the prevailing views on genetic causes have been reviewed. In the first, published in 1987, Kringlen concluded that “schizophrenia involves the interaction of biological and environmental factors. However, neither genetically nor environmentally oriented research has yet been able to identify the etiological factors that are necessary and/or sufficient for the disorder… but are the genes necessary?”. In that same year McGuffin and colleagues remained perplexed over which clinical sets of symptoms are inherited and thus valid phenotypes for further genetic studies, and Baron provided cautious optimism to his conclusion that because mathematical genetic modeling confirms the heritable component for schizophrenia, new technology provided by the gene marker strategy will be the way to make progress. In 1991, I too was optimistic in my review of the field and concluded that the “reverse genetics” approach could be applied to studies of families with schizophrenia without knowledge of what a gene for this disorder would be doing, and without a prior working hypothesis (DeLisi and Lovett 1991). In fact, during this period excitement had already been generated by several linkages to regions of the genome being reported for schizophrenia and affective psychoses without ever identifying a clear responsible gene or its mechanism (reviewed in DeLisi et al. 2000).
KeywordsAffective Psychos Schizophrenia Susceptibility Human Molecular Genetic Schizophrenia Susceptibility Gene Molecular Psychiatry
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