Advertisement

Neuroimaging studies of auditory verbal hallucinations

  • Philip McGuire
Conference paper

Abstract

Auditory hallucinations are a central feature of schizophrenia and a source of distress and disability for many patients. Although often responsive to treatment, in about a third of patients they are resistant to treatment or only partially improve (Shergill et al. 1999). In patients with schizophrenia auditory hallucinations of speech (auditory verbal hallucinations) are the most common type, and these usually involve derogatory phrases addressed to the patient in the second person (Junginger and Frame 1985).

Keywords

Transcranial Magnetic Stimulation Auditory Hallucination Formal Thought Disorder Schizophrenia Research Auditory Imagery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aleman A, Bocker KB, Hijman R, de Haan EH, Kahn RS (2003a) Cognitive basis of hallucinations in schizophrenia: role of top-down information processing. Schizophrenia Research 1926:1–11Google Scholar
  2. Aleman A, Koen A, Böcker B, Hijman R, de Haan E, Kahn R (2003) Cognitive basis of hallucinations in schizophrenia: role of top-down information processing. Schizophrenia Research 64:175–185PubMedCrossRefGoogle Scholar
  3. Allen P, Johns L, Fu C, Broome M, Brammer M, Vythelingum N, McGuire PK (2004) Misattribution of external speech in patients with delusions and hallucinations. Schizophrenia Research (in press)Google Scholar
  4. Barta PE, Pearlson GD, Powers RE et al (1990) Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. American Journal of Psychiatry 39:784–788Google Scholar
  5. Bentall RP, Slade PD (1985) Reality testing and auditory hallucinations: a signal detection analysis. British Journal of Clinical Psychology 24:159–169PubMedCrossRefGoogle Scholar
  6. Blakemore SJ, Wolpert DM, Frith CD (2002) Abnormalities in the awareness of action. Trends in Cognitive Sciences 6:237–242PubMedCrossRefGoogle Scholar
  7. Cahill C, Silbersweig D, Frith C (1996) Psychotic experiences induced in deluded pa-tients using distorted auditory feedback. Cognitive Neuropsychiatry 1:201–211PubMedCrossRefGoogle Scholar
  8. Cleghorn JM, Franco S, Szechtman B et al (1992) Towards a brain map of auditory hallucinations. American Journal of Psychiatry 149:1062–1069PubMedGoogle Scholar
  9. Chua S, Wright I, Murray RM, Friston KJ, Liddle PF, McGuire PK (1997) Grey matter correlates of syndromes in schizophrenia: a semi-automated analysis of structural magnetic resonance images. British Journal of Psychiatry 170:406–410PubMedCrossRefGoogle Scholar
  10. DeLisi L, Hoff AL, Neale C, Kushner M (1994) Asymmetries in the superior temporal lobe in male and female first-episode schizophrenic patients: measures of the planum temporale and superior temporal gyrus by MRI. Schizophrenia Research 12:19–28PubMedCrossRefGoogle Scholar
  11. Dierks T, Linden DEJ, Jandl M, Formisano E, Goebel R, Lanfermann H, Singer W (1999) Activation of Heschl’s gyrus during auditory hallucinations. Neuron 22:615–621PubMedCrossRefGoogle Scholar
  12. Evans C, McGuire PK, David A (2000) Is auditory imagery defective in patients with auditory hallucinations? Psychological Medicine 30(1):137–148PubMedCrossRefGoogle Scholar
  13. Farah M J, Smith AF (1983) Perceptual interference and facilitation with auditory imagery. Perceptiion & Psychophysics 33(5):475–478CrossRefGoogle Scholar
  14. Frith CD, Done DJ (1987) Towards a neuropsychology of schizophrenia. British Journal of Psychiatry 153:437–443CrossRefGoogle Scholar
  15. Frith CD (1992) The Cognitive Neuropsychology of Schizophrenia. Erlbaum, Taylor & Francis, Hove, UKGoogle Scholar
  16. Fu C, Vythelingum N, Andrew C, Brammer M, Amaro Jr E, Williams S, McGuire PK (2001) Alien voices… who said that? Neural correlates of impaired verbal self-monitoring in schizophrenia. Neuroimage 13:1052CrossRefGoogle Scholar
  17. Garety PA, Kuipers E, Fowler D, Freeman D, Bebbington PE (2001) A cognitive model of the positive symptoms of psychosis. Psychological Medicine 31:189–195PubMedCrossRefGoogle Scholar
  18. Hoffman RE, Hawkins KA, Gueorguieva R, Boutros NN, Rachid F, Carroll K, Krystal JH (2003) Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Archives of General Psychiatry 60(1): 49–56PubMedCrossRefGoogle Scholar
  19. Johns L, McGuire PK (1999) Verbal self-monitoring and auditory hallucinations in schizophrenia. Lancet 353:469–470PubMedCrossRefGoogle Scholar
  20. Johns L, Rossell S, Ahmad F, Frith C, Hemsley D, Kuipers L, McGuire PK (2001) Auditory verbal hallucinations and defective verbal self-monitoring in schizophrenia. Psychological Medicine 31:705–715PubMedCrossRefGoogle Scholar
  21. Junginger J, Frame CL (1985) Self-report of the frequency and phenomenology of verbal hallucinations. The Journal of Nervous & Mental Disease 173:149–155CrossRefGoogle Scholar
  22. Liddle PF, Friston KJ, Frith CD, Hirsch SR, Jones T, Frackowiak RSJ (1992) Patterns of cerebral blood flow in schizophrenia. British Journal of Psychiatry 160:179–186PubMedCrossRefGoogle Scholar
  23. McGuire PK, Syed GMS, Murray RM (1993) Increased blood flow in Broca’s area during auditory hallucinations in schizophrenia. Lancet 342:703–706PubMedCrossRefGoogle Scholar
  24. McGuire PK, Silbersweig DA, Wright I, Murray RM, David AS, Frackowiak R, Frith CD (1995) Abnormal perception of inner speech: a physiological basis for auditory hallucinations. Lancet 346:596–600PubMedCrossRefGoogle Scholar
  25. McGuire PK, Silbersweig DA, Frith CD (1996) Functional neuroanatomy of verbal self-monitoring. Brain 119:907–917PubMedCrossRefGoogle Scholar
  26. McGuire PK, Frith CD (1996) Disordered functional connectivity and schizophrenia. Psychological Medicine 26:663–667PubMedCrossRefGoogle Scholar
  27. Seal M, Aleman A, McGuire P (2004) Alluring imagery, unanticipated speech and deceptive memory: neurocognitive models of auditory verbal hallucinations in schizophrenia. Cognitive Neuropsychiatry 9:43–72PubMedCrossRefGoogle Scholar
  28. Shenton ME, Kikinis R, Jolesz FA, Pollack SD, LeMay M, Wible CG, Hokama H, Martin J, Metcalf D, Coleman M, McCarley RW (1992) Abnormalities of the left temporal lobe and thought disorder in schizophrenia. A quantitative magnetic resonance imaging study. New England Journal of Medicine 327:604–612PubMedCrossRefGoogle Scholar
  29. Shergill S, Murray RM, McGuire PK (1998) Auditory hallucinations: a review of psychological treatments. Schizophrenia Research 32:137–150PubMedCrossRefGoogle Scholar
  30. Shergill S, Bullmore E, Williams S, Brammer M, Murray RM, McGuire PK (2000) Functional anatomy of auditory verbal imagery in patients with auditory verbal hallucinations. American Journal of Psychiatry 157:1691–1693PubMedCrossRefGoogle Scholar
  31. Shergill S, Brammer M, Williams S, Murray RM, McGuire PK (2000) Mapping auditory hallucinations in schizophrenia using functional magnetic resonance imaging. Archives of General Psychiatry 57:1033–1038PubMedCrossRefGoogle Scholar
  32. Shergill S, Cameron L, Brammer M, Williams S, Murray RM, McGuire PK (2002) Modality-specif neural correlates of auditory and somatic hallucinations. Journal of Neurology, Neurosurgery & Psychiatry 71:688–690CrossRefGoogle Scholar
  33. Shergill S, Fukuda R, Brammer M, Murray RM, McGuire PK (2002) Modulation of temporal cortical activity during generation of inner speech. Human Brain Mapping 16:219–227PubMedCrossRefGoogle Scholar
  34. Shergill S, Fukuda R, Brammer M, Murray RM, McGuire PK (2003) Impaired monitoring of inner speech in schizophrenia. British Journal of Psychiatry 182:525–531PubMedCrossRefGoogle Scholar
  35. Vita A, Dieci M, Giobbio GM, Caputo A, Ghiringhelli M, Garbarini M, Medini AP, Morganti C, Tenconi F, Cesana B, Invernizzi G (1995) Language and thought disorder in schizophrenia: brain morphological correlates. Schizophrenia Research 15:243–251PubMedCrossRefGoogle Scholar
  36. Vita A, Dieci M, Giobbio GM, Caputo A, Ghiringhelli M, Garbarini M, Medini AP, Morganti C, Tenconi F, Cesana B, Invernizzi G (1995) Language and thought disorder in schizophrenia: brain morphological correlates. Schizophrenia Research 15:243–251PubMedCrossRefGoogle Scholar
  37. Wright IC, McGuire PK, Poline J-B, Travere JM, Murray RM, Frackowiak RSJ, Friston KJ (1995) A voxel-based method for the statistical analysis of grey and white matter density applied to schizophrenia. Neuroimage 2:244–252PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Philip McGuire
    • 1
  1. 1.Institute of PsychiatryLondonUK

Personalised recommendations