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Genetic liability, brain structure and symptoms of schizophrenia

  • Andrew McIntosh
  • Heather Whalley
  • Dominic Job
  • Eve Johnstone
  • Stephen Lawrie
Conference paper

Abstract

Over 100 structural MRI (sMRI) studies of schizophrenia have demonstrated that the structure of the brain in vivo is different from that of healthy controls. When the brain abnormalities arise and how they relate to the clinical symptoms are less certain. Such questions are not only of interest for theoretical reasons, but are also relevant to clinicians who may seek to detect schizophrenia at an earlier stage or perhaps to prevent it altogether. A better understanding of regional brain anomalies and their relationship to clinical symptoms may also inform us of the presence of subsyndromes (endophenotypes) and the boundaries of schizophrenia with other illnesses such as affective disorder.

Keywords

Psychotic Symptom Hippocampal Volume High Risk Subject Genetic Liability Obligate Carrier 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Andrew McIntosh
    • 1
  • Heather Whalley
    • 1
  • Dominic Job
    • 1
  • Eve Johnstone
    • 1
  • Stephen Lawrie
    • 1
  1. 1.Division of PsychiatryRoyal Edinburgh HospitalEdinburghUK

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