Skip to main content

Abstract

One or more large nodules may occasionally appear in a congenital nevus. As a rule, the nevus is of the “large” or “giant” type and the patient is very young. However, similar nodules can be rarely found in smaller congenital nevi and analogues can even appear in adulthood. The nodules may protrude above the surface of the congenital nevus or can be situated deeply within the lesion. The common denominator of the nevi in which proliferative nodules occur seems to be their depth rather than their diameter. In most cases, the deep reticular dermis and subcutaneous septa contain cords and strands of small, round melanocytes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ackerman AB, Guo Y, Vitale P, Vossaert K. Clues to diagnosis in dermatopathology, vol.III, Chicago, ASCP Press, 1993; p.257–260.

    Google Scholar 

  • Arao T, Yamada M, Matsunaga W, Kageshita T, Ono T. Proliferating giant pigmented nevus: a report of an unusual tumor occurring in association with a congenital giant pigmented nevus. J Invest Dermatol. 1989 May;92(5 Suppl):315S–317S.

    Article  PubMed  CAS  Google Scholar 

  • Barnhill RL, Fleischli M. Histologic features of congenital melanocytic nevi in infants 1 year of age or younger. J Am Acad Dermatol. 1995 Nov;33(5 Pt 1):780–785.

    Article  PubMed  CAS  Google Scholar 

  • Bastian BC, Xiong J, Frieden IJ, Williams ML, Chou P, Busam K, Pinkel D, LeBoit PE. Genetic changes in neoplasms arising in congenital melanocytic nevi: differences between nodular proliferations and melanomas. Am J Pathol. 2002 Oct;161(4):1163–1169.

    Article  PubMed  CAS  Google Scholar 

  • Clark WH, Elder DE, Guerry D. Dysplastic nevi and malignant melanoma. In: Pathology of the Skin. Ed. 1, edited by Farmer ER Hood AF. New York, McGraw Hill, 1990, p. 729–735

    Google Scholar 

  • Elder DE, Clark WH Jr, Elenitsas R, Guerry D 4th, Halpern AC. The early and intermediate precursor lesions of tumor progression in the melanocytic system: common acquired nevi and atypical (dysplastic) nevi. Semin Diagn Pathol. 1993 Feb;10(1):18–35.

    PubMed  CAS  Google Scholar 

  • Hoang MP, Sinkre P, Albores-Saavedra J. Rhabdomyosarcoma arising in a congenital melanocytic nevus. Am J Dermatopathol. 2002 Feb;24(1):26–29.

    Article  PubMed  Google Scholar 

  • Lowes MA, Norris D, Whitfeld M. Melanocytic proliferative nodule within a congenital naevus. Australas J Dermatol. 2000 May;41(2): 109–111.

    Article  PubMed  CAS  Google Scholar 

  • Mancianti ML, Clark WH, Hayes FA, Herlyn M. Malignant melanoma simulants arising in congenital nevi do not show experimental evidence for a malignant phenotype. Am. J. Pathol. 1990;136: 817–829.

    PubMed  CAS  Google Scholar 

  • Martinez-Barba E, Polo-Garcia LA, Ferri-Niguez B, Ruiz-Macia JA, Kutzner H, Requena L. Congenital giant melanocytic nevus with pigmented epithelioid cells: a variant of epithelioid blue nevus. Am J Dermatopathol. 2002 Feb;24(1):30–35.

    Article  PubMed  Google Scholar 

  • Pearson JP, Weiss SW, Headington JT. Cutaneous malignant melanocytic neurocristic tumors arising in neurocristic hamartomas. Am J Surg Path 1996;20:665–677.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Massi, G., Leboit, P.E. (2004). Proliferative Nodules in Congenital Nevi. In: Histological Diagnosis of Nevi and Melanoma. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-7985-1943-5_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-7985-1943-5_7

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-62222-9

  • Online ISBN: 978-3-7985-1943-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics