Melanoma on Palms, Soles and Subungual Melanoma Acral Melanoma

  • Guido Massi
  • Philip E. Leboit


Melanomas on acral skin seem to be of two types. Those on the sun damaged dorsal surfaces of the hands (and to a lesser extent, the feet) include a number of conventional melanomas. A more specific type is composed of melanomas on the volar surfaces of the acra, by which we mean the hairless areas of the hands and feet (mostly the palms and soles) and nail beds. In the majority of cases, these melanomas have a distinct lentiginous pattern of growth reminiscent of the lentigo maligna pattern of melanoma and of those of mucous membranes. This type of melanoma must be distinguished from melanocytic nevi found on the same sites. Melanomas of the hands and feet, and of nail beds have different epidemiology and genetic features than conventional melanoma. Because of special considerations, we describe melanoma on the nail apparatus separately.


Nail Plate Melanocytic Nevus Superficial Spreading Nail Matrix Acral Lentiginous Melanoma 
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  1. Blessing K, Kernohan NM, Park KG. Subungual malignant melanoma. Histopathology. 1991 Nov;19(5):425–429.PubMedCrossRefGoogle Scholar
  2. Boyd AS, Rapini RP. Acral melanocytic neoplasms: a histologic analysis of 158 lesions. J Am Acad Dermatol. 1994 Nov;31(5 Pt 1):740–745.PubMedCrossRefGoogle Scholar
  3. Cho KH, Kim BS, Chang SH, Lee YS, Kim KJ. Pigmented nail with atypical melanocytic hyperplasia. Clin Exp Dermatol. 1991 Nov; 16(6): 451–454.PubMedCrossRefGoogle Scholar
  4. Coleman WP, Loria PR. Acral lentiginous melanoma. Arch Dermatol. 1980 Jul;116(7):773–776.PubMedCrossRefGoogle Scholar
  5. David SS, Ramakrishna B. Acral lentiginous melanoma in situ. Eur J Surg. 1992 Apr;158(4):247–248.PubMedGoogle Scholar
  6. Finley RK 3rd, Driscoll DL, Blumenson LE, Karakousis CP. Subungual melanoma. Surgery. 1994 Jul;116(1):96–100.PubMedGoogle Scholar
  7. Hove LM, Akslen LA. Clinicopathological characteristics of melanomas of the hand. J Hand Surg [Br]. 1999 Aug;24(4):460–464.Google Scholar
  8. Ichimiya M, Yamamoto K, Hamamoto Y, Muto M. A case of atypical melanosis of the foot. J Dermatol. 2002 Feb;29(2):117–118.PubMedGoogle Scholar
  9. Kato T, Tabata N, Suetake T, Tagami H. Non-pigmented nodular plantar melanoma in 12 Japanese patients. Br J Dermatol. 1997 Feb;136(2):207–2ll.PubMedCrossRefGoogle Scholar
  10. Kuchelmeister C, Schaumburg-Lever G, Garbe C. Acral cutaneous melanoma in Caucasians. Br J Dermatol. 2000 Aug;143(2): 275–280.PubMedCrossRefGoogle Scholar
  11. Linares MD, Hardisson D, Perna C. Subungual malignant melanoma of the hand: unusual clinical presentation. Scand J Plast Reconstr Surg Hand Surg. 1998 Sep;32(3):347–350.PubMedCrossRefGoogle Scholar
  12. Reed RJ, Martin P. Variants of melanoma. Semin Cutan Med Surg. 1997 Jun;16(2):137–158.PubMedCrossRefGoogle Scholar
  13. Ridgeway CA, Hieken TJ, Ronan SG, Kim DK, Das Gupta TK. Acral lentiginous melanoma. Arch Surg. 1995 Jan;130(1):88–92.PubMedCrossRefGoogle Scholar
  14. Rigby HS, Briggs JC. Subungual melanoma: a clinico-pathological study of 24 cases. Br J Plast Surg. 1992 May–Jun;45(4):275–278.PubMedCrossRefGoogle Scholar
  15. Saida T. Malignant melanoma in situ on the sole of the foot. Its clinical and histopathologic characteristics. Am J Dermatopathol. 1989 Apr;11(2):124–130.PubMedCrossRefGoogle Scholar
  16. Signoretti S, Annessi G, Puddu P, Faraggiana T. Melanocytic nevi of palms and soles: a histologcal study according to the plane of section. Am J Surg Pathol. 1999 Mar;23(3):283–287.PubMedCrossRefGoogle Scholar
  17. Takematsu H, Obata M, Tomita Y, Kato T, Takahashi M, Abe R. Subungual melanoma. A clinicopathologic study of 16 Japanese cases. Cancer. 1985 Jun 1;55(11):2725–2731.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Guido Massi
    • 1
  • Philip E. Leboit
    • 2
  1. 1.Department of PathologyCatholic University Medical SchoolRomeItaly
  2. 2.University of CaliforniaSan FranciscoUSA

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