“Common” Nevus

(lentigo simplex Junctional nevus, compound nevus, intradermal nevus and Clark nevus) and uncommon variants
  • Guido Massi
  • Philip E. Leboit


Lacking of better names we use these simplistic definitions to encompass melanocytic neoplasms which are by and large the most common nevi encountered in routine practice: lentigo simplex, junctional nevus, compound nevus and intradermal nevus. These lesions are supposed to be the progressive stages of a melanocytic neoplasm’s natural evolution. The first step is lentigo simplex characterized by the distinct proliferation of melanocytes in single units aligned along the epidermal basal layer.


Papillary Dermis Melanocytic Nevus Balloon Cell Reticular Dermis Melanocytic Neoplasm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Ackerman AB, Milde P. Naming acquired melanocytic nevi. Am J Dermatopathol. 1992;14:447–453.PubMedCrossRefGoogle Scholar
  2. Bhawan J, Malhotra R. Simultaneous occurrence of intradermal nevus and syringoma. Cutis 1983;31:669–672.PubMedGoogle Scholar
  3. Brownstein MR, Starink TM. Desmoplastic tricoepithelioma and intradermal nevus: a combined malformation. J Am Acad Dermatol 1987;17:489–492.PubMedCrossRefGoogle Scholar
  4. Clark WH Jr, Elder DE, Guerry D et al. A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol 1984; 15:1147–1165.PubMedCrossRefGoogle Scholar
  5. Cohen LM, Bennion SD, Johnson TW et al. Hypermelanotic nevus: clinical, histopathologic, and ultrastructural features in 316 cases. Am J Dermatopathol. 1997 Feb;19(1):23–30.PubMedCrossRefGoogle Scholar
  6. Cohen PR, Rapini RP. Nevus with cyst. A report of 93 cases. Am J Dermatopathol. 1993 Jun;15(3):229–234.PubMedCrossRefGoogle Scholar
  7. Collina G, Eusebi V. Naevocytic naevi with vascular-like spaces. Brit J Dermatol 1991; 124: 591–595.CrossRefGoogle Scholar
  8. Demitsu T, Kakurai M, Jamada T, Kiyosawa T et al. The vascular space-like structure in melanocytic nevus is not an injection artifact: report of a case an experimental study. J Dermatol. 1998;25(3):143–149.PubMedGoogle Scholar
  9. Eng W, Cohen PR. Nevus with fat. J Am Acad Dermatol 1998;39:704–711.PubMedCrossRefGoogle Scholar
  10. Gray MH, Smoller BR, McNutt NS, Hsu A. Neurofibromas and neurotized melanocytic nevi are immunohistochemically distinct neoplasm. Am J Dermatopathol 1990; 12(3): 234–241.PubMedCrossRefGoogle Scholar
  11. Jordaan HF. Follicular mucinosis in association with melanocytic nevus. J Cutan Pathol 1987; 14:122–126.PubMedCrossRefGoogle Scholar
  12. Harris GR, Shea CR, Horenstein MG et al. Desmoplastic (sclerotic) nevus. Am J Surg Pathol. 1999 Jul;23(7):786–794.PubMedCrossRefGoogle Scholar
  13. Jih DM, Morgan MB, Bass J, Tuthill R, Somach S. Oncocytic metaplasia occurring in a spectrum of melanocytic nevi. Am J Dermatopathol. 2002 Dec;24(6):468–472.PubMedCrossRefGoogle Scholar
  14. Kelly JW, Rivers J, MacLennan R. Sunlight: a major factor associated with the development of melanocytic nevi in Australian schoolchildren. J Am Acad Dermatol 1994; 30:40–48.PubMedCrossRefGoogle Scholar
  15. Kerl H, Soyer HP, Cerroni L, Wolfl H, Ackerman AB. Ancient melanocytic nevus. Semin Diagn Pathol. 1998 Aug;15(3):210–215.PubMedGoogle Scholar
  16. Larsen TE, Mogensen SB, Holme I. Seasonal variations of pigmented naevi. Acta Derm Venereol 1990; 70:115–120.PubMedGoogle Scholar
  17. MacDonald DM, Black MM. Secondary localized cutaneous amyloidosis in melanocytic naevi. Brit J Dermatol 1980; 103: 553–556.CrossRefGoogle Scholar
  18. Mehregan DR, Mehregan DA, Mehregan AH. Nodular myxoid change in melanocytic nevi. Am J Dermatopathol 1996;18:400–402.PubMedCrossRefGoogle Scholar
  19. Moulin G, Souquet D, Balme B. Pigmented nevus and cutaneous ossifications. A propos of 125 cases of osteonevi. Ann Dermatol Venereol. 1991;118(3):199–204.PubMedGoogle Scholar
  20. Nogita T, Kawashima M. Subclinical syringoma coexisting with nevocellular nevus on the vulva. J Dermathol. 1993; 20(3): 188–189.Google Scholar
  21. Requena L, Yus SE. Trichostasis spinulosa within an intradermal melanocytic nevus. Cutis 1991;48:211–212.PubMedGoogle Scholar
  22. Richard MA, Grob JJ, Gouvernet J. Role de 1’exposition solaire sur les naevus mélanocytaires benins. Ann Dermatol Venereol 1994, 121:639–644.PubMedGoogle Scholar
  23. Rompel R, Meyer W. Zerebriformer intradermaler Navus. Hautarzt 1993; 44: 238–241.PubMedGoogle Scholar
  24. Sagebiel RW. Histologic artifacts of benign pigmented nevi. Arch Derm 1972; 106: 691–693.PubMedCrossRefGoogle Scholar
  25. Schmoeckel C. Classification of melanocytic nevi. Am J Dermatopathol 1997; 19(1): 31–34.PubMedCrossRefGoogle Scholar
  26. Shapiro PE. Making sense of the dysplastic nevus controversy. A unifying perspective. Am J Dermatopathol. 1992 Aug;14(4):350–356.PubMedCrossRefGoogle Scholar
  27. Tomita K, Furukawa F, Tokura Y. A nevocellular nevus consisting mostly of nevi corpuscles. J Dermatol 1998; 25:134–135.PubMedGoogle Scholar
  28. Tronnier M, Wolff HH. UV-irradiated melanocytic nevi simulating melanoma in situ. Am J Dermatopathol 1995; 17(1): 1–6.PubMedCrossRefGoogle Scholar
  29. Wallace H. Tribute to Ian Whimster. Am J Dermatopathol 1985; 7: Suppl A7–A15.PubMedCrossRefGoogle Scholar
  30. Weedon D. Unusual features of nevocellular nevi. J Cutan Pathol 1982; 9: 284–292.PubMedCrossRefGoogle Scholar
  31. Williams ML, Pennella R. Melanoma, melanocytic nevi and other risk factors in children. J Pediatr 1994; 124:833.PubMedCrossRefGoogle Scholar
  32. Wolinsky S, Silvers D. The small lentiginous nevus. Am J Dermatopathol 1985;7:5–11.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Guido Massi
    • 1
  • Philip E. Leboit
    • 2
  1. 1.Department of PathologyCatholic University Medical SchoolRomeItaly
  2. 2.University of CaliforniaSan FranciscoUSA

Personalised recommendations