Neurotropic Melanoma

  • Guido Massi
  • Philip E. Leboit


Neurotropic melanoma is a form of spindle cell melanoma which exhibits perineural and endoneural spread (neurotropism) and a fascicular nerve-like growth pattern (neural differentiation). Desmoplasia can be a feature and indeed neurotropic melanoma is related to desmoplastic melanoma, as outlined in the last chapter. This peculiar form of neoplasm was first described in detail by Dr. Richard Reed.


Neural Differentiation Malignant Peripheral Nerve Sheath Tumor Pigment Lesion Dysplastic Nevus Blue Nevus 
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  1. Barnhill RL, Bolognia JL. Neurotropic melanoma with prominent melanization. J Cutan Pathol 1995 Oct;22(5):450–459.PubMedCrossRefGoogle Scholar
  2. Carlson JA, Dickersin GR, Sober AJ, Barnhill RL. Desmoplastic neurotropic melanoma. A clinicopathologic analysis of 28 cases. Cancer. 1995 Jan 15;75(2):478–494.PubMedCrossRefGoogle Scholar
  3. Gutzmer R, Herbst RA, Mommert S, Kiehl P, Matiaske F, Rutten A, Kapp A, Weiss J. Allelic loss at the neurofibromatosis type 1 (NF1) gene locus is frequent in desmoplastic neurotropic melanoma. Hum Genet. 2000 Oct;107(4):357–361.PubMedCrossRefGoogle Scholar
  4. Iyadomi M, Ohtsubo H, Gotoh Y, Kohda H, Narisawa Y. Neurotropic melanoma invading the median nerve. J Dermatol. 1998 Jun;25(6):379–383.PubMedGoogle Scholar
  5. Jacinto CM, Grant-Kels JM, Knibbs DR, Daman LA, Piorkowski RJ. Malignant primitive neuroectodermal tumor presenting as a scalp nodule. Am J Dermatopathol. 1991 Feb;13(1):63–70.PubMedCrossRefGoogle Scholar
  6. Khalil MK, Duguid WP. Neurotropic malignant melanoma of right temple with orbital metastasis: a clinicopathological case report. Br J Ophthalmol. 1987 Jan;71( 1):41–46.PubMedCrossRefGoogle Scholar
  7. Kossard S, Doherty E, Murray E. Neurotropic melanoma. A variant of desmoplastic melanoma. Arch Dermatol. 1987 Jul;123(7):907–912.PubMedCrossRefGoogle Scholar
  8. Payne WG, Kearney R, Wells K, Blue M, Walusimbi M, Mosiello G, Cruse CW, Reintgen D. Desmoplastic melanoma. Am Surg. 2001 Oct;67(10):1004–1006.PubMedGoogle Scholar
  9. Quinn MJ, Crotty KA, Thompson JF, Coates AS, O’Brien CJ, McCarthy WH. Desmoplastic and desmoplastic neurotropic melanoma: experience with 280 patients. Cancer. 1998 Sep 15;83(6):1128–1135.PubMedCrossRefGoogle Scholar
  10. Reed RJ, Leonard DD. Neurotropic melanoma. A variant of desmoplastic melanoma. Am J Surg Pathol. 1979 Aug;3(4):301–311.PubMedCrossRefGoogle Scholar
  11. Suster S, Amazon K, Rosen LB, Ollague JM. Malignant epithelioid schwannoma of the skin. A low-grade neurotropic malignant melanoma? Am J Dermatopathol. 1989 Aug;11(4):338–344.PubMedCrossRefGoogle Scholar
  12. Warner TF, Ford CN, Hafez GR. Neurotropic melanoma of the face invading the maxillary nerve. J Cutan Pathol. 1985 Dec; 12(6):520–527.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Guido Massi
    • 1
  • Philip E. Leboit
    • 2
  1. 1.Department of PathologyCatholic University Medical SchoolRomeItaly
  2. 2.University of CaliforniaSan FranciscoUSA

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