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Lentigo Maligna Pattern of Melanoma in Situ and Melanoma

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Histological Diagnosis of Nevi and Melanoma

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Abstract

Lentigo maligna is a pattern of melanoma in situ in severely sun damaged skin. Clinically, the lesion is found on chronically sun-exposed areas of the elderly and is a gradually enlarging brownish macule. Histologically, lentigo maligna is characterized by a long intrabasal growth phase, with inconsistent or no pagetoid spread. The evolution towards invasive melanoma is more frequently in the form of a spindle cell or desmoplastic melanoma than in other types. For all the above-mentioned distinctive features, lentigo maligna deserves to be treated separately from more common forms of melanoma in situ. It may prove to have genetic differences from other forms, reflecting a different pathogenesis.

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Authors and Affiliations

  1. Department of Pathology, Catholic University Medical School, Largo F. Vito, 1, 00168, Rome, Italy

    Prof. Guido Massi M.D. (Professor of Pathology and Dermatopathology)

  2. University of California, 1701 Divisadero St, Room 350, CA, 94115, San Francisco, USA

    Philip E. Leboit M.D. (Professor of Dermatopathology)

Authors
  1. Prof. Guido Massi M.D.
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  2. Philip E. Leboit M.D.
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© 2004 Springer-Verlag Berlin Heidelberg

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Massi, G., Leboit, P.E. (2004). Lentigo Maligna Pattern of Melanoma in Situ and Melanoma. In: Histological Diagnosis of Nevi and Melanoma. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-7985-1943-5_27

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  • DOI: https://doi.org/10.1007/978-3-7985-1943-5_27

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-62222-9

  • Online ISBN: 978-3-7985-1943-5

  • eBook Packages: Springer Book Archive

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