Lentigo Maligna Pattern of Melanoma in Situ and Melanoma

  • Guido Massi
  • Philip E. Leboit


Lentigo maligna is a pattern of melanoma in situ in severely sun damaged skin. Clinically, the lesion is found on chronically sun-exposed areas of the elderly and is a gradually enlarging brownish macule. Histologically, lentigo maligna is characterized by a long intrabasal growth phase, with inconsistent or no pagetoid spread. The evolution towards invasive melanoma is more frequently in the form of a spindle cell or desmoplastic melanoma than in other types. For all the above-mentioned distinctive features, lentigo maligna deserves to be treated separately from more common forms of melanoma in situ. It may prove to have genetic differences from other forms, reflecting a different pathogenesis.


Basal Layer Invasive Melanoma Desmoplastic Melanoma Lentigo Maligna Solar Elastosis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Guido Massi
    • 1
  • Philip E. Leboit
    • 2
  1. 1.Department of PathologyCatholic University Medical SchoolRomeItaly
  2. 2.University of CaliforniaSan FranciscoUSA

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