Combined Nevus

  • Guido Massi
  • Philip E. Leboit


The finding of two (or sometimes even three) cytologically different populations of melanocytes in the same nevus is called combined nevus. The two forms of nevus usually maintain not only their cytologic identity, but also their architectural characteristics. Some of the proliferative nodules seen in congenital nevi (chapter 7) can also be considered a form of combined nevus. As noted below, while most lesions are acquired nevi by history, a pattern suggesting congenital origin is seen in almost every case. Combined nevi are easily confused with melanoma arising in a nevus, both in terms of their clinical appearance and microscopically.


Melanocytic Nevus Nevus Cell Rete Ridge Congenital Origin Blue Nevus 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Guido Massi
    • 1
  • Philip E. Leboit
    • 2
  1. 1.Department of PathologyCatholic University Medical SchoolRomeItaly
  2. 2.University of CaliforniaSan FranciscoUSA

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