Deep Penetrating Nevus

  • Guido Massi
  • Philip E. Leboit


The deep penetrating nevus is an intradermal or sometimes compound melanocytic neoplasm with three distinctive histological characteristics: — it occupies a large part of the dermis, occasionally reaching the subcutis; — it contains large cells with pale cytoplasm and a variably sized nucleus; — and it has a dark color on clinical examination due to its many melanophages. Its pigmentation, periadnexal pattern and equal size of cells at the top and base of the lesion are findings that suggest that it is a variant of blue nevus.


Metastatic Melanoma Atypical Cell Blue Nevus Pale Cytoplasm Junctional Component 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Guido Massi
    • 1
  • Philip E. Leboit
    • 2
  1. 1.Department of PathologyCatholic University Medical SchoolRomeItaly
  2. 2.University of CaliforniaSan FranciscoUSA

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