Skip to main content

Abstract

Primary cardiac tumors are very rare clinical entities, with benign neoplasms occurring three to four times more often (70–90%) than malignant tumors (10–30%). Only series of myxomas in adults have been reported, while very few series involving different types of primary cardiac tumors in children have been reported. In this chapter only types of pediatric cardiac tumors occurring in the pediatric age will be considered. Metastatic cardiac neoplasms are not included. The ability to detect cardiac tumors with noninvasive diagnostic procedures even during the prenatal period has led to an apparent increase in this diagnosis, with incidences reported from 0.06% cases to 0.32%, while the reported autopsy series was limited to 0.027–0.08%.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Agarwala B (2003) Rapid disappearance of a huge cardiac rhabdomyoma in an infant. Cardiol Young 13:173–174

    Article  PubMed  Google Scholar 

  • Alkalay AL, Ferry DA, Lin B, Fink BW, Pomerance JJ (1987) Spontaneous regression of cardiac rhabdomyoma in tuberous sclerosis. Clin Pediatr 26:532–535

    Article  CAS  Google Scholar 

  • Arciniegas E, Hakimi M, Farooki ZQ, Truccone NJ, Green EW (1980) Primary cardiac tumors in children. J Thorac Cardiovasc Surg 79:582–591

    PubMed  CAS  Google Scholar 

  • Becker AE (2000) Primary heart tumors in the pediatric age group: a review of salient pathologic features relevant for clinicians. Pediatr Cardiol 21:317–323

    Article  PubMed  CAS  Google Scholar 

  • Bini RM, Westaby S, Bargeron LM, Pacifico AD, Kirklin JW (1983) Investigation and management of primary cardiac tumors in infants and children. J Am Coll Cardiol 2:351–357

    Article  PubMed  CAS  Google Scholar 

  • Bittner HB, Sharma AD, Landolfo KP (2000) Surgical resection of an intracardiac rhabdomyoma. Ann Thorac Surg 70:2156–2158

    Article  PubMed  CAS  Google Scholar 

  • Bloomberg RD, Butany JW, Cusimano RJ, Leask RL (2003) Primary cardiac sarcoma involving the pulmonary artery and valve. Can J Cardiol 19:843–847

    PubMed  Google Scholar 

  • Bosi G, Lintermans JP, Pellegrino PA, Svaluto-Moreolo G, Vliers A (1996) The natural history of cardiac rhabdomyoma with and without tuberous sclerosis. Acta Paediatr 85:928–931

    Article  PubMed  CAS  Google Scholar 

  • Cho JM, Danielson GK, Puga FJ, Dearani JA, McGregor CGA, Tazelaar HD, Hagler DJ (2003) Surgical resection of ventricular cardiac fibromas: early and late results. Ann Thorac Surg 76:1929–1934

    Article  PubMed  Google Scholar 

  • Corno AF, de Simone G, Catena G, Marcelletti C (1984) Cardiac rhabdomyoma: surgical treatment in the neonate. J Thorac Cardiovasc Surg 87:725–731

    PubMed  CAS  Google Scholar 

  • Corno AF, Marianeschi S, Giannico S, Parisi F, Marino B (1989) Cardiac rhabdomyoma in infancy. CI Res 37:92A

    Google Scholar 

  • Corno AF (1996) Fetal echocardiography for neonatal cardiac tumors. J Am Coll Cardiol 28:1080

    PubMed  CAS  Google Scholar 

  • Costas C, Williams RL, Fortune RL (1986) Intracardiac teratoma in an infant. 7:179–181

    CAS  Google Scholar 

  • D’Addario V, Pinto V, Di Naro E, Del Bianco A, Di Cagno L, Volpe P (2002) Prenatal diagnosis and postnatal outcome of cardiac rhabdomyomas. J Perinat Med 30:170–175

    Article  PubMed  Google Scholar 

  • Di Liang C, Ko SF, Huang SC (2000) Echocardiographic evaluation of cardiac rhabdomyoma in infants and children. J Clin Ultrasound 28:381–386

    Article  PubMed  Google Scholar 

  • Duncan WJ, Freedom RM, Rowe RD (1982) Space-occupying lesions of the myocardium: role of two-dimensional echocardiography in detection of cardiac tumors in children. Am Heart J 104:780–785

    Article  PubMed  CAS  Google Scholar 

  • Elderkin RA, Radford DJ (2002) Primary cardiac tumours in a paediatric population. J Paediatr Child Health 38:173–177

    Article  PubMed  CAS  Google Scholar 

  • Engle MA, Ebert PA, Redo SF (1974) Recurrent ventricular tachycardia due to respectable cardiac tumor. Circulation 50:1052–1057

    Article  PubMed  CAS  Google Scholar 

  • Eslami-Varzaneh F, Brun EA, Sears-Rogan P (2003) An unusual case of multiple papillary fibroelastoma, review of literature. Cardiovasc Pathol 12: 170–173

    Article  PubMed  Google Scholar 

  • Freedom RM, Lee KJ, MacDonald C, Taylor G (2000) Selected aspects of cardiac tumors in infancy and childhood. Pediatr Cardiol 21:299–316

    Article  PubMed  CAS  Google Scholar 

  • Fyler DC, Buckley LP, Hellenbrand WE, Cohn HE (1980) Report of the New England Regional Infant Care Program. Pediatrics 65(Suppl):375–461

    Google Scholar 

  • Gamzu R, Achiron R, Hegesh J, Weiner E, Tepper R, Nir A, Rabinowitz R, Auslander R, Yagel S, Zalel Y, Zimmer E (2002) Evaluating the risk of tuberous sclerosis in cases with prenatal diagnosis of cardiac rhabdomyoma. Prenat Diagn 22:1044–1047

    Article  PubMed  Google Scholar 

  • Geha AS, Weidman WH, Soule EH, McGoon DC (1967) Intramural ventricular cardiac fibroma. Circulation 36:427–440

    Article  PubMed  CAS  Google Scholar 

  • Geipel A, Krapp M, Germer U, Becker R, Gembruch U (2001) Ultrasound Obstet Gynecol 17:17–21

    Article  PubMed  CAS  Google Scholar 

  • Golding R, Reed G (1967) Rhabdomyoma of the heart. N Engl J Med 276:957–960

    Article  PubMed  CAS  Google Scholar 

  • Gowdamarajan A, Michler RE (2002) Therapy for primary cardiac tumors: ppis there a role for heart transplantation? Curr Opin Cardiol 15:121–125

    Article  Google Scholar 

  • Harding CO, Pagon RA (1990) Incidence of tuberous sclerosis in patients with cardiac rhabdomyoma. Am J Med Genet 37:443–446

    Article  PubMed  CAS  Google Scholar 

  • Harinck E, Moulaert AJMG, Rohmer J, Brom GA (1974) Cardiac rhabdomyoma in infancy. Acta Paediatr Scand 63:283–286

    Article  PubMed  CAS  Google Scholar 

  • Hoffmeier A, Scheid HH, Tjan TD, Schneider M, Kerber S, Schmidt C, Schmid C (2003) Ex situ resection of primary cardiac tumors. Thorac Cardiovasc Surg 51:99–101

    Article  PubMed  CAS  Google Scholar 

  • Houser S, Forbes N, Stewart S (1980) Rhabdomyoma of the heart: a diagnostic and therapeutic challenge. Ann Thorac Surg 29:373–377

    Article  PubMed  CAS  Google Scholar 

  • Jiang ZY, Pircova A, Sekarski N, Hack I, Laurini R, Janzer R, Payot M (2000) Transposition of the great arteries, pulmonary atresia, and multiple ventricular septal defects associated with multiple cardiac rhabdomyomas in a case of tuberous sclerosis. Pediatr Cardiol 21:165–169

    Article  PubMed  CAS  Google Scholar 

  • Kiaffas MG, Powell AJ, Geva T (2002) magnetic resonance imaging evaluation of cardiac tumor characteristics in infants and children. Am J Cardiol 89:1229–1233

    Article  PubMed  Google Scholar 

  • Kim JT, Baek WK, Kim KH, Yoon YH, Kim DH, Lim HK (2003) A primary cardiac sarcoma preoperatively presented as a benign left atrial myxoma. Yonsei Med J 44:530–533

    PubMed  CAS  Google Scholar 

  • Lam KY, Dickens P, Chan AC (1993) Tumors of the heart: a 20-year experience with a review of 12,485 consecutive autopsies. Arch Pathol Lab Med 117:1027–1031

    PubMed  CAS  Google Scholar 

  • Lethor JP, de Moor M (2001) Multiple cardiac tumors in the fetus. Circulation 103:E55

    Article  PubMed  CAS  Google Scholar 

  • Ludomirsky A (1998) Cardiac tumors. In: Bricker JT, Fisher DJ (Eds) The science and practice of pediatric cardiology, 9th ed. Williams & Wilkins; pp 1885–1893

    Google Scholar 

  • Mair DD, Titus JL, Davis GD, Ritter DG (1977) Cardiac rhabdomyoma simulating mitral atresia. Chest 71:102–105

    Article  PubMed  CAS  Google Scholar 

  • Marin-Garcia J, Fitch CW, Shenefelt RE (1984) Primary right ventricular tumor (fibroma) simulating cyanotic heart disease in a newborn. J Am Coll Cardiol 3:868–871

    Article  PubMed  CAS  Google Scholar 

  • Marino B, Corno AF, Carotti A, Pasquini L, Giannico S, Guccione P, Bevilacqua M, De Simone G, Marcelletti C (1990) Pediatric cardiac surgery guided by echocardiography. Scand J Thorac Cardiovasc Surg 24:197–201

    Article  PubMed  CAS  Google Scholar 

  • Marx GR, Moran AM (2000) Cardiac tumors. In: Moss and Adams “ Heart disease in infants, children and adolescents”, 6th ed. Lippincott, Williams and Wilkins, pp 1432–1445

    Google Scholar 

  • McMahon CJ, Ayres NA, Lewin MB (2001) Cardiac rhabdomyoma: a report of alternative strategies to surgical resection. Cardiol Young 11:670–672

    Article  PubMed  CAS  Google Scholar 

  • Padalino MA, Basso C, Svaluto-Moreolo G, Thiene G, Stellin G (2003) Left atrial Myxoma in a child: case report and review of the literature. Cardiovasc Pathol 12:233–236

    Article  PubMed  Google Scholar 

  • Percell RL, Henning RJ, Siddique Patel M (2003) Atrial myxoma: case report and a review of the literature. Heart Dis 5:224–230

    Article  PubMed  Google Scholar 

  • Pipitone S, Mongiovi M, Grillo R, Gagliano S, Sperandeo V (2002) Cardiac rhabdomyoma in intrauterine life: clinical features and natural history: a case series and review of published reports. Ital Heart J 3:48–52

    PubMed  Google Scholar 

  • Reece IJ, Houston AB, Pollock JCS (1983) Interventricular fibroma: echocardiographic diagnosis and successful surgical removal in infancy. Br Heart J 50:590–591

    Article  PubMed  CAS  Google Scholar 

  • Riggs TW, Sholl JS, Ilbawi M, Gardner T (1984) In utero diagnosis of pericardial tumour with successful surgical repair. Pediatr Cardiol 5:23–26

    Article  PubMed  CAS  Google Scholar 

  • Schmaltz AA, Apitz J (1982) Primary rhabdomyosarcoma of the heart. Pediatr Cardiol 2:73–75

    Article  PubMed  CAS  Google Scholar 

  • Schaher RM, Farina M, Alley R, Hansen P, Bishop M (1972) Congenital subaortic stenosis in infancy caused by rhabdomyoma of the left ventricle. J Thorac Cardiovasc Surg 63:157–163

    Google Scholar 

  • Shiono J, Horigome H, Yasui S, Miyamoto T, Takahashi-Igari M, Iwasaki N, Matsui A (2003) Electrocardiographic changes in patients with cardiac rhabdomyomas associated with tuberous sclerosis. Cardiol Young 13:258–263

    PubMed  Google Scholar 

  • Stellingwerff GC, Hess J, Bogers AJ (1999) Left ventricular rhabdomyoma. J Cardiovasc Surg 40:131–133

    CAS  Google Scholar 

  • Stiller B, Hetzer R, Mayer R, Dittrich S, Pees C, Alexi-Meskishvili V, Lange PE (2001) Primary cardiac tumours: when is surgery necessary? Eur J Cardiothorac Surg 20:1002–1006

    Article  PubMed  CAS  Google Scholar 

  • Takach TJ, Reul GJ, Ott DA, Cooley DA (1996) Primary cardiac tumors in infants and children: immediate and long term operative results. Ann Thorac Surg 62:559–564

    Article  PubMed  CAS  Google Scholar 

  • Tworetzky W, McElhinney DB, Margossian R, MoonGrady AJ, Sallee D, Goldmuntz E, van der Velde ME, Silverman NH, Allan LD (2003) Association between cardiac tumors and tuberous sclerosis in the fetus and neonate. Am J Cardiol 92:487–489

    Article  PubMed  Google Scholar 

  • Val-Bernal JF, Acebo E, Gomez-Roman JJ, Garijo MF (2003) Anticipated diagnosis of left atrial myxoma following histological investigation of limb embolectomy specimens: a report of two cases. Pathol Int 53:489–494

    Article  PubMed  Google Scholar 

  • Vander Salm TJ (2000) Unusual primary tumours of the heart. Semin Thorac Cardiovasc Surg 12:89–100

    Google Scholar 

  • Vaughan CJ, Veugelers M, Basson CT (2001) Tumors and the heart: molecular genetic advances. Curr Opin Cardiol 16:195–200

    Article  PubMed  CAS  Google Scholar 

  • Webb DW, Thomas RD, Osborne JP (1993) Cardiac rhabdomyomas and their association with tuberous sclerosis. Arch Dis Child 68:367–370

    Article  PubMed  CAS  Google Scholar 

  • Webb DW, Osborne JP (1995) Tuberous sclerosis. Arch Dis Child 72:471–474

    Article  PubMed  CAS  Google Scholar 

  • Williams WG, Trusler GA, Fowler RS, Scott ME, Mustard WT (1972) Left ventricular myocardial fibroma: a case report and review of cardiac tumors in children. J Pediatr Surg 7:324–328

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Corno, A.F. (2004). Cardiac tumors. In: Congenital Heart Defects. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-7985-1934-3_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-7985-1934-3_16

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-62158-1

  • Online ISBN: 978-3-7985-1934-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics