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Systemic inflammatory response after cardiac surgery: Is extracorporeal circulation the main culprit?

  • J. Börgermann
  • I. Friedrich

Abstract

Cardiac surgery with extracorporeal circulation (ECC) is associated with a systemic inflammatory response [28, 53]. Kirklin and coworkers described this phenomenon as early as 1981 and coined the term postperfusion syndrome [13]. In the majority of cases, the organism can fully compensate for this systemic inflammatory response syndrome (SIRS). But any postoperative exacerbation will increase morbidity and mortality. Surgical trauma, ischemia/reperfusion, endotoxinemia, and cellular activation induced by shear-stress and by the foreign-surfaces of the heart-lung machine are pathophysiological mechanisms that activate the systemic inflammatory response (Fig. 1).

Keywords

Cardiopulmonary Bypass Serum Vascular Endothelial Growth Factor Coronary Bypass Surgery Diopulmonary Bypass Conventional Coronary Artery Bypass Grafting 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • J. Börgermann
  • I. Friedrich

There are no affiliations available

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