Zusammenfassung
Bei Untersuchungen von Strukturvarianten bekannter Neuroleptika wurden vor über 60 Jahren die antidepressiven Wirkungen von Imipramin entdeckt. Mit der überzeugenden Wirksamkeit des Imipramin und seinen Analogenden trizyklischen Antidepressiva — wurde eine neue Ära in der medikamentösen Behandlung der Depression eingeläutet. Alle trizyklischen Antidepressiva hemmen die Wiederaufnahme von Neurotransmittern, insbesondere von den biogenen Aminen Serotonin, Noradrenalin und Dopamin. Ihre anticholinerge Wirkung ist therapeutisch unerwünscht und verursacht typische Nebenwirkungen wie Mundtrockenheit, verschwommenes Sehen und Harnverhalten. Bald danach wurden die Monoaminoxidase-Inhibitoren entdeckt, die durch Hemmung des Abbauenzyms der biogenen Amine eine vergleichbare Wirkung erzielten. Die zufällige Beobachtung der stimmungsaufhellenden Wirkung des Tuberkulosemedikaments Iproniazid in den frühen 50er Jahren und die Bestätigung der Wirkung bei depressiven Patienten führte zu der Erkenntnis, dass eine Nebenwirkung — die Hemmung der Monoaminoxidase — ein neues Prinzip zur Behandlung der Depression darstelle. Diese beiden Substanzklassen bildeten über viele Jahre die Standardtherapie der Depression. Hauptproblem sind die zum Teil schweren kardiotoxischen Nebenwirkungen, wobei etwa nach Suizidversuchen die Herzrhythmusstörungen schwer in den Griff zu bekommen sind.
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Literatur
Literatur zu Abschnitt 4.1
Akiskal HS (1994) Dysthymic and cyclothymic depressions: therapeutic considerations. J Clin Psychiatry 55(Suppl 4):46–52
Akiskal HS, Cassano GB (eds) (1997) Dysthymia and the spectrum of chronic depressions. Guilford Press, New York
American Psychiatric Association (2000) Practice guideline for the treatment of patients with major depressive disorder (revision). Am J Psychiatry 157(Suppl 4):l–45
Angst J, Sellaro R, Merikangas KR (2000) Depressive spectrum diagnoses. Compr Psychiatry 41(Suppl l):39–47
Armitage R, Yorkers K, Cole D et al (1997) A multicenter, double-blind comparison of the effects of nefazodone and fluoxetine on sleep architecture and quality of sleep in depressed outpatients. J Clin Psychopharmacol 17:161–168
Appels AD (2002) Depression and cardiac disease. Curr Opin Psych 15(l):59–62
Baldassano CF, Sachs GS, Stoll AL et al (1995) Paroxetine for bipolar depression: outcome in patients failing prior antidepressant trials. Depression 3:182–186
Ballenger JC, Wheadon DE, Steiner M et al (1998) Double-blind, fixed-dose, placebo-controlled study of paroxetine in the treatment of panic disorder. Am J Psychiatry 155(l):36–42
Ban TA, Gszner P et al (1998) Clinical Efficacy of Reboxetine: a Comparative Study with Desipramine, with Methodological Considerations. Human Psychopharmacol 13:29–39
Bauer M (1995) The combined use of lithium and SSRIs. J of Serotonin Research 2:69–76
Bauer M et al (2002) World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for biological treatment of unipolar depressive disorders, part 2: Maintenance treatment of major depressive disorder and treatment of chronic depressive disorders and subthreshold depressions. World J Biol Psychiatry 3(2):69–86
Baumann P, Nil R, Bertschy G et al (1998) A double-blind double-dummy study of citalopram comparing infusion versus oral administration. J Affective Disorders 49:203–210
Benkert O, Szegedi A, Wetzel H et al (1997) Dose escalation vs. continued doses of paroxetine and maprotiline: a prospective study in depressed out-patients with inadequate treatment response. Acta Psychiatr Scand 95:288–296
Berzewski H, Van Moffaert M, Gagiano C (1997) Efficacy and tolerability of reboxetine compared with imipramine in a double-blind study in patients from major depressive episodes. European Neuropsychopharmacol 7(suppl):1:37–47
Bodkin JA, Amsterdam JD (2002) Transdermal Selegiline in Major Depression: A Double Blind, Placebo-Controlled, Parallel-Group Study in Outpatients. Am J Psychiatry 159:1869–1875
Bouwer C, Stein DJ (1998) Use of the selective serotonin reuptake inhibitor citalopram in the treatment of generalized social phobia. J Affective Disorders 49: 79–82
Bowden CL (1998) Key treatment studies of lithium in manic-depressive illness: Efficacy and side effects. J Clin Psychiatry 59(suppl 6):13–19
Bowden CL, Calabrese JR, McElroy SL (2000) A randomized, placebo controlled 12 month trial of divalproat and lithium in treatment of outpatients with bipolar I disorder. Arch Gen Psychiatry 57:481–489
Brambilla P, Barale F, Soares JC (2001) Perspectives on the use of anticonvulsants in the treatment of bipolar disorder. Int J Neuropsychopharm 4:421–446
Burnett FE, Dinan TG (1998) The clinical efficacy of venlafaxine in the treatment of depression. Rev Contemp Pharmacother 9:303–320
Calabrese J (2000) A double-blind, placebo controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. J Clin Psychiatry 61:841–850
Calabrese J (2000) A double blind placebo controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. J Clin Psychiatry 60:79–88
Carpenter L, Yasmin S, Price LH (2002) Eine doppelblinde Placebo-kontrollierte Studie über die Augmentation von Antidpressiva mit Mirtazapin. Biol Psychiatry 51:183–188
Chengappa KNR, Gershon S, Levine J (2001) The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder. Bipolar Disorders 3:215–232
Citrome L (2002) Current Treatments of Agitation and Aggression. http://www.medscape.com/viewprogram/1866_pnt
Coppen A (2000) Lithium in unipolar depression and the prevention of suicide. J Clin Psychiatry 61(Suppl 9):52–56
Davis JM et al (1999) Mood stabilizers in the prevention of recurrent affective disorders: a meta analysis. Acta Psychiatr Scand 100:406–417
De Jonghe F, Kool S, van Aalst G, Dekker J, Peen J (2001) Combining psychotherapy and antidepressants in the treatment of depression. J of Affective Disorder 64:217–229
Dierick M, Martin A, Ravizza L et al (1996) A double-blind comparison of venlafaxine and fluoxetine for treatment of major depression in outpatients. Prog Neuro-Psychopharmacol Biol Psychiatry Jan 20(l):57–71
Doogan DP, Caillard V (1992) Sertraline in the prevention of depression. Brit J Psychiatry 160:217–222
Dubini A, Bosc M, Polin V (1997) Noradrenaline-selective versus serotonin-selective antidepressant therapy: differential effects on social functioning. J Psychopharmacol 11(suppl 4):17–23
Dunner DL (1998) Lithium carbonate: Maintenance studies and consequencies of withdrawal. J Clin Psychiatry 59(suppl 6):48–55
Elliott AJ, Uldall KK, Bergam K et al (1998) Randomized, placebo-controlled trial of paroxetine versus imipramine in depressed HIV-positive outpatients. Am J Psychiatr 155(3):367–372
Fabre FL et al (1995) Sertraline safety and efficacy in major depression: a doubleblind fixed-dose comparison with placebo. Biol Psychiatry 38:592–602
Fava M, Rosenbaum J, Hoog S et al (1998) Fluoxetine versus sertraline and paroxetine in major depression: long term changes in weight. European Neuropsychopharmacol 8(suppl 2):204
Fava GA et al (1998) Prevention of recurrent depression with cognitive behavioral therapy: preliminary findings. Arch Gen Psychiatry 55:816–820
Feiger A, Kiev A, Shrivastava R et al (1996) Nefazodone versus sertraline in outpatients with major depression: Focus on efficacy, tolerability, and effects on sexual function and satisfaction. J Clin Psychiatry 57(suppl 2):53–62
Flament MF, Bisserbe JC (1997) Pharmacologic treatment of OCD: comparative studies. J Clin Psychiatr 58(suppl 12):18–22
Frampton M (1997) Citalopram: a review of pharmacology and clinical efficacy. J Serotonin Research 4:29–45
Franchini L et al (1997) A double blind study of long-term treatment with sertraline or fluvoxamine for prevention of highly recurrent unipolar depression. J Clin Psychiatry 58:104–197
Franchini L, Gasperini M, Perez J et al (1998) Dose-response efficacy of paroxetine in preventing depressive recurrences: a randomized, double-blind study. J Clin Psychiatry 59(5):229–232
Geretsegger C, Stuppaeck CH, Mair M et al (1995) Multicenter double blind study of paroxetine and amitryptiline in elderly depressed patients. Psychopharmacol 119:277–281
Ghose K (1997) Tolerance and side-effects of paroxetine in elderly depressed patients. Archives of Gerontol Geriatrics 24:35–45
Gorman JM, Korotzer A, Su G (2002) Efficacy Comparison of Escitalopram and Citalopram in the Treatment of Major Depressive Disorder: Pooled Analysis of Placebo-Controlled Trials. Med Works Media 40–44
Gottfries CG (1996) Scandinavian experience with citalopram in the elderly. International Clinical Psychopharmacology 11(suppl l):41–44
Heal D, Cheetham S et al (1992) Comparative Pharmacology of Dothiepin, its Metabolites, and Other Antidepressant Drugs. Drug Development Res 27:121–135
Healy D, McMonagle T (1997) The enhancement of social functioning as a therapeutic principle in the management of depression. J Psychopharmacol 11(suppl 4):25–31
Hindmarch I (1997) The effects of antidepressants on psychomotor function with particular reference to reboxetine. European Neuropsychopharmacol 7(suppl 1):17–21
Hindmarch I (1998) Effect of Antidepressants on Cognitive and Psychomotor Function: the Lack of Effect of Reboxetine. Human Psychopharmacol 13:21–27
Judd LL (1997) The clinical course of unipolar major depressive disorders. Arch Gen Psychiatry 54:989–991
Judd LL, Akiskal HS (2000) Delineating the longitudinal structure of depressive illness: beyond subtypes and duration thresholds. Pharmacopsychiatry 33:3–7
Judd LL et al (2000) Does incomplete recovery from first lifetime major depressive episode herald a chronic course of illness? Am J Psychiatry 157:1501–1504
Katona CLE, Hunter BN, Bray J (1998) A double-blind comparison of the efficacy and safety of paroxetine and imipramine in the treatment of depression with dementia. Int J Geriatric Psychiatry 13:100–108
Katzelnik DJ et al (1995) Sertraline for social phobia: a double-blind, placebo controlled crossover study. Am J Psychiatry 152:1368–1371
Keller MB, Kocsis JH, Thase ME et al (1998) Maintenance phase efficacy of sertraline for chronic depression. JAMA 280(19):1665–1671
Keller MB et al (2000) A comparison of nefazodone, the cognitive behavioralanaly-sis system of psychotherapy and their combination for the treatment of chronic depression. N Engl J Med342:1462–1470
Kerr JS, Hindmarch I (1996) Citalopram and other antidepressants: comparative effects on cognitive function and psychomotor performance. J Serotonin Res 3:123–129
Kerr JS, Fairweather DB, Hindmarch I (1997) The effect of paroxetine and dothiepin on subjective sleep in depressed patients. Human Psychopharmacol12:71–73
Kessler RC et al (1994) Lifetime and 12 month prevalence of DSM-III-R psychiatric disorders in the United States. Arch Gen Psychiatry 51:8–19
Klein DN et al (1988) Double depression and episodic major depression: demographic, clinical, familial, personality, and socioenvironmental characteristics and short-term outcome. Am J Psychiatry 145:1226–1231
Klerman GL, Weissman MM (1989) Increasing rates of depression. JAMA 261:2229–2235
Kocsis JH, Friedman RA, Markovitz JC et al (1996) Maintenance therapy for chronic depression. A controlled clinical trial of desipramine. Arch Gen Psychiatry 53:769–774
Kocsis JH, Zisook S, Davidson J et al (1997) Double-blind comparison of sertraline, imipramine, and placebo in the treatment of dysthymia: psychosocial outcomes. Am J Psychiatry 154:390–395
Kupfer DJ (1993) Management of recurrent depression. J Clin Psychiatry 54 (Suppl 2):29–33
Lader M (1996) Citalopram — a new antidepressant. Primary Care Psychiatry 2:49–58
Lane R, Baldwin D, Preskorn S (1995) The SSRIs: advantages, disadvantages and differences. J Psychopharmacol 9(Suppl 2):163–178
Lecrubier Y (1995) Clinical utility of venlafaxine in comparison with other antidepressants. Int Clin Psychopharmacol 10(suppl 2):29–35
Lecrubier Y, Bakkier A, Dumbar G et al (1997) A comparison of paroxetine, clomipramine and placebo in the treatment of panic disorder. Acta Psychiatr Scand 95:145–152
Lecrubier Y, Judge R et al (1997) Long-term evaluation of paroxetine, clomipramine and placebo in panic disorder. Acta Psychiatr Scand 95:153–160
Lepola UM, Wade AG, Leinonen EV et al (1998) A controlled, prospective, 1-year trial of citalopram in the treatment of panic disorder. J Clin Psychiatry 59(10):528–534
Lima MS, Moncrieff J (2001) Drugs versus placebo for dysthymia (Cochrane Review). In: The Cochrance Library, Issue 1, 2001 Update Software, Oxford
Londborg PD, Wolow R, Smith WT et al (1998) Sertraline in the treatment of panic disorder. A multi-site, double-blind, placebo-controlled, fixed-dose investigation. Brit J Psychiatry 173:54–60
Marshall RD, Schneier FR, Fallon BA et al (1998) An open trial of paroxetine in patients with noncombat-related, chronic posttraumatic stress disorder. J Clin Psychopharmacol 18(l):10–18
Massana J (1998) Reboxetine Versus Fluoxetine: an Overview of Efficacy and Tolerability. J Clin Psychiatry 59(suppl)
McElroy SL, Arnold LM, Shapira NA et al (2003) Topiramate in the Treatment of Binge Eating Disorder Associated with Obesity: A randomized, placebo-controlled trial. Am J Psychiatry 160(2):255–261
Mendels J, Kiev A, Fabre LF (1999) Double-blind comparison of citalopram and placebo in depressed outpatients with melancholia. Depression and Anxiety 9:54–60
Menza MA, Kaufman KR, Castellanos AM (2000) Modafinil Augmentation of Antidepressant Treatment in Depression. J Clin Psychiatry 378–381
Miller NL et al (2001) Maintenance desipramine for dysthymia: a placebo controlled study. J Affect Disord 64:231–237
Montgomery SA (1997) Reboxetine: additional benefits to the depressed patient. J Psychopharmacol ll(suppl 4):9–15
Montgomery SA (1999) New developments in the treatment of depression. J Clin Psychiatry 60(Suppl 14):10–15
Montgomery SA, Djärv L (1996) The antidepressant efficacy of citalopram. Intern Clin Psychopharmacol ll(suppl l):29–33
Moscovich DG, Shapira B et al (1992) Rapid Lithiumization in Acute Manic Patients. Human Psychopharm 7:343–345
Mucci M (1997) Reboxetine: a review of antidepressant tolerability. J Psychopharmacol 11(suppl 4):33–37
Müller-Öhrlinghausen B et al (1999) Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. Am J Psychiatry 156:1000–1006
Nemeroff CB (2000) An ever increasing pharmacopoeia for the management of patients with bipolar disorder. J Clin Psychiatry 61(suppl 13):19–25
Newhouse PA (1996) Use of serotonin selective reuptake inhibitors in geriatric depression. J Clin Psychiatry 57(suppl 5):12–22
Nolen WA, Bloemkolk D (2000) Treatment of bipolar depression, a review of the literature and a suggestion for an algorithm. Neuropsychobiology 42(suppl 1): 11–17
Nierenberg AA (2001) Long-term management of chronic depression. J Clin Psychiatry 62(Suppl 6):17–21
Nulman I, Rovet J et al (1997) Neurodevelopment of Children exposed in Utero to Antidepressant Drugs. New England J Medicine 336(4):258–262
Ontiveros A, Garcia-Barriga C (1997) A double-blind, comparative study of paroxetine and fluoxetine in out-patients with depression. Brit J Clinical Research 8:23–32
Peet M, Pratt P (1993) Lithium: Current Status in Psychiatric Disorders. Drugs 46:7–17
Pohl RB, Wolkow RM, Clary C (1998) Sertraline in the treatment of panic disorder: a double-blind multicenter trial. Am J Psychiatry 155(9):1189–1195
Pollack MH, Otto MW, Worthington JJ et al (1998) Sertraline in the treatment of panic disorder. A flexible-dose multicenter trial. Arch Gen Psychiatry 55(ll):1010–1016
Potter WZ, Rudorfer MV, Manji H (1991) The pharmacologic treatment of depression. New England J Medicine 325(9):633–642
Ravidran AV, Judge R, Hunter BN et al (1997) A double-blind, multicenter study in primary care comparing paroxetine and clomipramine in patients with depression and associated anxiety. J Clin Psychiatry 58(3):112–118
Rocca P, Fonzo V, Scotta Met al (1997) Paroxetine efficacy in the treatment of generalized anxiety disorder. Acta Psychiatr Scand 95:444–450
Rush AJ, Thase ME (1997) Strategies and tactics in the treatment of chronic depression. J Clin Psychiatry 58(Suppl 13):14–22
Salokangas RKR, Saarijärvi S, Taiminen T et al (1996) Citalopram as an adjuvant in chronic schizophrenia: a double-blind placebo-controlled study. Acta Psychiatr Scand 94:175–180
Schou M (1997) Lithiumbehandlung der manisch-depressiven Krankheit. Thieme, Stuttgart (4. Aufl.)
Schou M (2000) Suicidal behavior and prophylactic lithium treatment of major mood disorders: a review of reviews. Suicide Life Threat Behav 30:289–293
Scott J (1988) Chronic depression. Br J Psychiatry 153:287–297
Shekelle PG et al (1999) Clinical guidelines: developing guidelines. BMJ 318: 593–596
Simon GE (2002) Implementing depression treatment guidelines. Curr Opin Psych 15(l):77–82
Sinclair J, Birtwistle J, Baldwin D (1998) The tolerability of venlafaxine. Rev Contemp Pharmacother 9:333–344
Smith D, Dempster C, Glanville J, Freemantle N, Anderson I (2002) Efficacy and tolerability of venlafaxine compared with selective serotonin reuptake inhibitors and other antidepressants: a meta-analysis. Brit J Psychiatry 180:396–404
Stein DJ, Bouwer C, Maud CM (1997) Use of selective serotonin reuptake inhibitor citalopram in treatment of trichotillomania. Eur Arch Psychiatry Clin Neurosci 247:234–236
Stein MB, Liebowitz MR, Lydiard B et al (1998) Paroxetine treatment of generalized social phobia (social anxiety disorder). A randomized controlled trial. JAMA 280(8):708–713
Sundblad C, Wikander I, Andersch B et al (1997) A naturalistic study of paroxetine in premenstrual syndrome: efficacy and side-effects during ten cycles of treatment. Eur Neuropsychopharmacol 7:201–206
Taiminen TJ, Syvällahti E, Saarijärvi S et al (1997) Citalopram as an adjuvant in schizophrenia: further evidence for a serotonergic dimension in schizophrenia. Intern Clin Psychopharmacol 12:31–35
Thase ME (1999) Long-term nature of depression. J Clin Psychiatry 60(Suppl 14): 3–9
Thase ME, Faca M, Halbreich U et al (1996) A placebo-controlled, randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia. Arch Gen Psychiatry 53:777–784
Thase ME, Greenhouse JB, Frank E, Reynolds CF, Pilkonis PA, Hurley K, Grochocinski V, Kupfer DJ (1997) Treatment of Major Depression with psychotherapy-pharmacotherapy combinations. Arch Gen Psychiatry 54:1009–1015
Thase ME, Entsuah RA, Rudolph RL (2001) Remission rates during treatment with venlafaxine or selective serotonin reuptake inhibitors. Brit J Psychiatry 178:234–241
Thies-Flechtner K et al (1996) Effect of prophylactic treatment on suicide risk in patients with major affective disorders. Data from a randomised prospective trial. Pharmacopsychiatry 29:103–107
Tiihonen J, Ryynänen OP, Kauhanen J et al (1996) Citalopram in the treatment of alcoholism: a double-blind placebo-controlled study. Pharmacopsychiat 29:27–29
Tome MB, Isaac MT, Harte Ret al (1997) Paroxetine and pindolol: a randomized trial of serotonergic autoreceptor blockade in the reduction of antidepressant latency. Int Clin Psychopharmacol 12:81–89
Tondo L, Ross MD, Baldessarini RJ et al (1998) Lithium maintenance treatment of depression and mania in bipolar I and bipolar II disorders. Am J Psychiatry 155(5):638–645
Tondo L, Baldessarini RJ, Floris (2001) Long term clinical effectiveness of lithium maintenance treatment in types I and II bipolar disorders. Br J Psychiatry 178(suppl 41):184–190
Tueth MJ, Murphy TK, Evans DL (1998) Special considerations: use of lithium in children, adolescents, and elderly populations. J Clin Psychiatry 59(suppl 6): 66–73
Van Moffaert et al (1995) A controlled comparison of sertraline and fluoxetine in acute and continuation treatment of major depression. Human Psychopharmacol 10:393–405
Verkes RJ, Van der Mast RC, Hengeveld MW et al (1998) Reduction by paroxetine of suicidal behavior in patients with repeated suicide attempts but not major depression. Am J Psychiatry 155(4):543-547
Versiani M, Cassano G, Perugi G et al (2002) Reboxetine, a Selective Norepinephrine Reuptake Inhibitor, is an effective and well-tolerated Treatment for Panic Disorder. J Clin Psychiatry 63(l):31–37
Wade AG, Lepola U, Koponen J, Pedersen V, Pedersen T (1997) The effect of citalopram in panic disorder. Br J of Psychiatry 170:549–553
Waldinger M, Hengeveld MW, Zwinderman AH et al (1998) Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol 18(4):274–281
Weissman MM et al (1988) The epidemiology of dysthymia in five communities: rates, risks, comorbidity and treatment. Am J Psychiatry 145:815–819
Wells K, Sherbourne C, Schoenbaum Met al (2000) Impact of disseminating quality improvement programs for depression in managed primary care: a randomized controlled trial. JAMA 283:212–230
Wheatley D (1998) Vergleich des Johanniskrautextraktes LI 160 mit Amitriptylin bei leichter bis mittelschwerer Depression. Psychopharmakother Suppl 8:8–11
Wheeler Vega LA, Mortimer AM, Tyson PJ (2000) Somatic treatment of psychotic depression: review and recommendations for practice. J Clin Psychopharmacol 20:504–519
Winkler D et al (2002) Maintenance treatment in depression: the role of pharmacological and psychological treatment. Curr Opin Psych 15(l):63–68
Wittchen HU (2000) Epidemiology of affective disorders. In: Helmchen H, Henn F, Lauter H, Sartorius (eds) Contemporary Psychiatry, Vol 3. Springer, Heidelberg
World Federation of Societies of Biological Psychiatry (WFSBP) (2002) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1: Acute and Continuation Treatment of Major Depressive Disorder. J Biol Psychiatry 3(l):5–44. Part 2: Maintenance Treatment of Major Depressive Disorder and Treatment of Chronic Depressive Disorders and Subthreshold Depressions 3(2):69-87
Yonkers K, Gullion C, Williams A et al (1998) Paroxetine as a treatment of premenstrual dysphoric disorder. J Clin Psychopharmacol 16(l):3–8
Zajecka JM (2000) Clinical Issues in Long-Term Treatment with Antidepressants. J Clin Psychiatry 61(suppl 2):20–25
Zanardi R, Franchini L, Gasperini M et al (1996) Double-blind controlled trial of sertraline versus paroxetine in the treatment of delusional depression. Am J Psychiatry 153:1631–1633
Zohar J, Judge Ret al (1996) Paroxetine versus clomipramine in the treatment of obsessive-compulsive disorder. Brit J Psychiatr 169:468–474
Literatur zu Abschnitt 4.2
Beckmann H, Haas S (1984) Therapie mit Benzodiazepinen: eine Bilanz. Nervenarzt 55:111–121
Benkert O, Hippius H (1986) Psychiatrische Pharmakotherapie. Springer, Berlin Heidelberg New York
Berner P (1982) Psychiatrische Systematik. Huber, Bern Stuttgart Wien
Braestrup C, Nielsen M, Olsen CE (1980) Urinary and brain β-carboline-3-carbo-cylates as potent inhibitors of brain benzodiazepine receptors. Proc Natl Acad Sci USA 77:2288–2292
Braestrup C, Schmiechen R, Neef G, Nielsen M, Petersen EN (1982) Interaction of convulsive ligands with benzodiazepine receptors. Science 216:1241–1243
Chase MH, Parmeggiani PL, O’Connor C (1991) Sleep research, vol 20 A. In: World Fed Sleep Res Soc, Found Congr, Cannes Fr, Sept 21-25, 1991
Clarenbach P, Klotz U, Koella WP, Rudolf GAE (1991) Schering Lexikon der Schlafmedizin. Medizin, München
Cluydts R, Peeters K et al (1998) Comparison of Continous versus Intermittent Administration of Zolpidem in Chronic Insomniacs: a Double-blind, Randomized Pilot Study. J Int Med Res 26:13–24
Costa E, Guidotti A, Mao CC (1975) New concepts on the mechanism of actions of benzodiazepines. Life Sci 17:167–186
Davidson JRT, DuPont RL, Hedges D, Haskins T (1999) Efficacy, Safety and Tolerability of Venlafaxine Extended Release and Buspirone in Outpatients with Generalized Anxiety Disorder. J Clin Psychiatry 60(8):528–535
Delle Chiaie R, Pancheri P, Casacchia M et al (1995) Assessment of the efficacy of buspirone in patients affected by generalised anxiety disorder, shifting to buspirone from prior treatment with lorazepam: a placebo-controlled, doubleblind study. J Clin Psychopharmacol 15:12–19
Dorow R, Horowski R, Paschelke G, Amin M, Braestrup C (1983) Severe anxiety induced by FG 7142, a β-carboline receptor. Lancet II:98–99
Freeman H, Puech AJ, Roth T (eds) (1996) Zolpidem: an update of its pharmacological properties and therapeutic place in the management of insomnia. Elsevier, Paris
Friedberg KD, Rüfer R (1986) Benzodiazepine. Urban 8c Schwarzenberg, München
Gilin JC, Byerley WF (1990) The diagnosis and management of insomnia. N Engl J Med 322(4):239–247
Griffiths RR, Sannerud CA (1987) Abuse of and dependence on benzodiazepines and other anxiolytic/sedative drugs. In: Meltzer HY et al (1987) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 1535–1541
Griffiths RR, Summerud JD (1985) The benzodiazepines. In: Smith DE, Wesson DR (eds) Current standards for medical practice. MTP, Lancaster, pp 209–225
Griffiths RR, McLeod D, Bigelow GE, Liebson IA, Roach JD (1984) Relative abuse liability of diazepam and oxazepam: behavioral and subjective dose effects. Psychopharmacology 84:147–154
Haase HJ (1982) Therapie mit Psychopharmaka und anderen psychotropen Medikamenten. Schattauer, Stuttgart
Hindmarch I, Ott H, Roth T (1984) Sleep, benzodiazepines and performance. Psychopharmacology Suppl. Springer, Berlin Heidelberg New York
Hippius H, Engel RR, Laakmann G (1986) Benzodiazepine. Rückblick und Ausblick. Springer, Heidelberg
Hoey LL, Nahum A, Vance-Bryan K (1994) A retrospective review and assessment of benzodiazepines in the treatment of alcohol withdrawal in hospitalized patients. Pharmacotherapy 14(5):572–578
Janke W, Netter P (1986) Angst und Psychopharmaka. Kohlhammer, Stuttgart
Kimbel KH (1984) Arzneimittel und Schlaflosigkeit: Stellungnahme einer amerikanischen Expertenkonferenz. 48(40):2892–2897
Klotz U (1985) Tranquillantien. Therapeutischer Einsatz und Pharmakologie. Wissenschaftliche Verlagsgesellschaft, Stuttgart
Lader MH, Marks IM (1971) Clinical anxiety. Heinemann, London
Lader MH (1994) Benzodiazepines: a Risk-Benefit Profile. CNS Drugs l(5):377–387
Langer G, Heimann H (1983) Psychopharmaka. Springer, Wien
Laux G (1988) Psychopharmaka — ein Leitfaden. Fischer, Stuttgart New York
Laux G (1989) Tranquilizer; Psychiatrie für den Praxisalltag. Hippokrates, Stuttgart
Linde OK (1988) Pharmakopsychiatrie im Wandel der Zeit. Tilia, Klingenmünster Monti J, Monti D (1995) Pharmacological treatment of chronic insomnia. CNS Drugs 4:182–194
Müller C (1973) Lexikon der Psychiatrie. Springer, Berlin Heidelberg New York
Müller-Oerlinghausen B (1984) Benzodiazepine — wo liegen die Gemeinsamkeiten, wo die Unterschiede. Psycho 10:561–573
Nutt DJ, Ballenger JC, Sheehan D, Wittchen HU (2002) Generalized anxiety disorder: comorbidity comparative biology and treatment. International Journal of Neuropsychopharmacology 5:315–325
Pöldinger W, Gander G (1979) Psychopharmaka in der Praxis. Roche, Paris
Pollack MH (2002) Treatment of Anxiety Disorders in the Presence of Comorbid Depression. http://www.medscape.com/viewarticle/436974_3
Rickels K, Case WG, Downing RW, Winokur A (1985) Benzodiazepine Use and Abuse. In: Hemali D, Racagni G (eds) Chronic treatments in neuropsychiatry. Raven, New York, pp 193–204
Rüther E et al (1992) Epidemiologie, Pathophysiologie, Diagnostik und Therapie von Schlafstörungen. MHW 134, 8/29:460–466
Saletu B (1989) Biologische Psychiatrie. Thieme, Stuttgart
Schmidt LG (1988) Zur Häufigkeit primärer Benzodiazepinabhängigkeit, A-2598 (56). Dtsch Ärztebl 85:38
Schmidt RF, Vogel ME, Zimmermann M (1967) Die Wirkung von Diazepam auf die präsynaptische Hemmung und andere Rückenmarksreflexe. Arch Pharmakol Exp Pathol 258:69–82
Schofield PR, Darlison MG, Jujiita N, Burt DR, Stephenson FA, Rodriguez H, Rhel LM, Ramachandran I, Reale V, Glencorse TA, Seeburg PH, Barnard EA (1987) Sequence and functional expression of the GABA-A receptor shows a ligandgated receptor super-family. Nature (London) 328:221–227
Sheehan DV (1982) Panic attacks and phobias. J Med 307:156–158
Sheehan DV (1983) The anxiety disease. Bantam, New York
Spector R, Rogers H, Roy D (1984) Psychiatry: common drug treatments; practical problems in medicine. Dunitz, London
Sternbach L (1988) Die Benzodiazepinstory. In: Linde OK (Hrsg) Pharmakopsychiatrie im Wandel der Zeit. Tilia, Klingenmünster, S 271–299
Young A, Klapp R, Sherbourne C, Wells K (2001) The quality of care for depressive and anxiety disorders in the United States. Arch Gen Psychiatry 58:55–61
Wang P, Berglund P, Kessler R (2000) Recent care of common mental disorders in the United States: prevalence and conformance with evidence based recommendations. J Gen Intern Med 15:284–292
Wiegand M, Berger B (1987) Welche Bedeutung haben Antidepressiva in der Behandlung von chronischen Schlafstörungen. In: Hippius H, Rüther E (Hrsg) Antidepressiva und Depressionsbehandlung in der ärztlichen Praxis. Springer, Berlin Heidelberg New York, S 52–59
Wildmann J, Möhler H, Vetter W, Ranalder V, Schmidt K, Maurer K (1987 a) Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin. J Neural Transmiss 70:383–398
Literatur zu Abschnitt 4.3
Ackenheil M, Hippius H, Matussek N (1978) Ergebnisse der biochemischen Forschung auf dem Schizophrenie-Gebiet. Nervenarzt 49:634–649
Amsler HA, Teerenhovi I, Barth E et al (1977) Agranulocytosis in patients treated with Clozapine. A study of the Finnish epidemic. Acta Psychiat Scand 56:241–248
Andreasen NC (1987) The concept of negative symptoms: definition, specificity and significance. Psychiat Psychobiol II, 4:240–251
Angst J, Bente D, Berner P et al (1971) Das klinische Wirkungsbild von Clozapin (Untersuchungen mit dem AMP-System). Pharmakopsychiat Neuropsychopharmakol 4:201–211
Arvanitis LA (1996) Clinical Profile of Seroquel™ (Quetiapine): An overview of recent clinical studies. In: Holliday SG, Ancill RJ, MacEwan GW (eds) Schizophrenia: Breaking down the barriers. John Wiley & Sons Ltd
Arvanitis LA, Miller BG (1996) ICI 204, 636, an atypical antipsychotic: Results from a multiple fixed-dose, placebo-controlled trial. Psychopharm Bulletin 32(3):391
Ayd FJ Jr (1978) Haloperidol: twenty years’ clinical experience. J Clin Psychol 39b:807–814
Ban TA, Ceskova E (1980) Long-acting antipsychotic drugs. Psychopharmacol 16:6–13
Bauer D, Gärtner HJ (1983) Wirkungen der Neuroleptika auf die Leberfunktion, das blutbildende System, den Blutdruck und die Temperaturregulation. Pharmakopsychiatrie 16:23–29
Berzewski H (1983) Der psychiatrische Notfall. Perimed, Erlangen
Bilder RM, Goldman RS, Volavka J et al (2002) Neurocognitive effects of clozapine, olanzapine, resperidone and haloperidol in patients with chronic schizophrenia or schizoaffective disorder. Am J Psychiatry 159:18–1028
Bobon J, Pinchard A, Collard J (1972) Clinical classification of neuroleptic with special reference to their antimanic, antiautistic and ataraxic properties. Compr Psychiat 13:123–131
Borenstein P, Boyer P, Braconnier A et al (1989) Amisulpride. Expansion Scientifique Francaise, Paris
Breier A (1995) The management of treatment-resistant schizophrenia. Current Opinion in Psychiatry 8(l):41–44
Brown GW, Birley JTL, Wing JK (1972) Influence of family life on the course of schizophrenic disorders: a replication. Br J Psychiat 121:241–258
Buchanan R, Koro CE, Weiss S, L’Italian GJ, Magder LS, Fedder DO (2002) Effect of Olanzapine and Risperidone use on Diabetes Risk in Schizophrenia. Int J Neuropsychopharm 5(suppl 1):169
Bürki HR (1983) Neurobiochemische Wirkungen der Neuroleptika. In: Langer G, Heimann H (Hrsg) Psychopharmaka: Grundlagen und Therapie. Springer, Berlin Heidelberg New York, S 207–223
Carlsson A (1978) Antipsychotic drugs, neurotransmitters, and schizophrenia. Am J Psychiat 135(2):164–173
Carlsson A (1990) In: Acad Prof Inf Serv NY (ed) Psychiatric topics 2(1)
Carlsson A, Waters N, Waters S, Carlsson M (2000) Network Interactions in Schizophrenia — therapeutic implications. Brain Research Reviews 31:342–349
Casey DE (1996) “Seroquel”(Quetiapine). Preclinical and clinical findings of a new atypical antipsychotic. Exp Opin Invest Drugs 5(8):939–957
Chong SA, Mahendran R (2001) Cardiac Effects of Psychotropic Drugs. Annals Academy of Medicine 30(6):625–631
Copolov DL, Link CGG, Kowalcyk B (2000) A multicentre, double-blind, randomized comparison of quetiapine (ICI 204,636,“Seroquel”) and haloperidol in schizophrenia. Psychological Medicine 30:95–105
Cornblatt B, Kern RS, Carson WH, Ali MW, Luo X, Green M (2002) Neurocognitive Effects of Aripiprazolane versus Olanzapine in stable Psychosis. Int J Neuropsychopharmacol 5(suppl 1):185
Costentin J (1987) Neuroleptiques et récepteurs dopaminergiques. Psychol Med 19, 13:2413–2416
Crow TJ (1985) The two syndrom concept: origins and current status. Schizophr Bull II, 3:471–486
Cuesta MJ, Peralta V, Zarzuela A (2001) Effects of olanzapine and other antipsychotics on cognitive function in chronic schizophrenia: a longitudinal study. Schizophren Res 48:17–28
Daniel DG, Zimbroff DL, Potkin SG et al (1999) Ziprasidone 80 mg/day and 160 mg/day in the acute exacerbation of Schizophrenia and Schizoaffective Disorder: A 6 Week Placebo Controlled Trial. Neuropsychopharmacology 20(5): 491–505
Davis JM (1976) Recent developments in the drug treatment of schizophrenia. Am J Psychiat 133:208–214
Davis JM, Andriukaitis S (1986) The natural course of schizophrenia and effective maintenance drug treatment. J Clin Psychopharmacol 6:2 S–10 S
Davy JP (1987) Les neuroleptiques àaction prolongée. Psychol Med 19, 13: 2407–2410
Delay J, Deniker P (1952) Trente-huit cas de psychoses traitées par la cure prolongée et continue de 4560 RP. In: 50 Congr Aliénistes et neurologues de la longue francaise, Luxembourg, 1952. Masson, Paris
Delay J, Deniker P (1961) Méthodes chimothérapeutiques en psychiatrie. Masson, Paris, p 496
Deniker P, Ginestet D (1973) Neuroleptiques. Encycl Med Chir Psychiat 37860b 20/2, 1–16 (Paris)
Falloon IRH (1982) Family management in the prevention of exacerbations of schizophrenia. A controlled study. N Engl J Med 306:1437–1440
Faurbye A, Rasch PJ, Petersen PB et al (1964) Neurological symptoms in pharmacotherapy of psychosis. Acta Psychiat Scand 40:10–27
Ferrari HA, Stephen CR (1966) Neuroleptanalgesia: pharmacology and clinical experiences with droperidol and fentanyl. S Afr Med J 59:815–820
Gicklhorn R (1960) Ein Beitrag zur Geschichte der Rauwolfia. Med Welt 11: 1788–1792
Goldstein MJ (1978) Drug and family therapy in the aftercare of acute schizophrenics. Arch Gen Psychiat 35:1169–1177
Goren JL, Levin GM (1998) Quetiapine, an Atypical Antipsychotic. Pharmacotherapy 18(6):1183–1194
Green MF, Braff DL (2001) Translating the basic and clinical cognitive neuroscience of schizophrenia to drug development and clinical trials of antipsychotic medications. Biol Psychiatry 49:374–384
Haase HJ (1961) Das therapeutische Achsensyndrom neuroleptischer Medikamente und seine Beziehungen zur extrapyramidalen Symptomatik. Fortschr Neurol Psychiat 29:245–268
Haase HJ (1976) Therapie mit Psychopharmaka und anderen seelischen Befinden beeinflussenden Medikamenten, 4. Aufl. Schattauer, Stuttgart
Haase HJ: Dosierung der Neuroleptica. Schwerpunktmedizin 5, 2 (Sonderh)
Hamner MB, Arvanitis LA, Miller B G et al (1996) Plasma Prolactin in Schizophrenia Subjects Treated with “Seroquel”(ICI 204, 636). Psychopharmacol Bulletin, 32(l):107–110
Hirsch SR, Gaind R, Rohde PD et al (1973) Outpatient maintenance of chronic schizophrenic patients with long-acting fluphenazine: double-blind placebo trial. Br Med J I:633–637
Hirsch SR, Link CG, Goldstein JM, Arvanitis LA (1996) ICI 204, 636: a new Atypical Antipsychotic Drug. Brit J Psychiatry 168(suppl 29):45–56
Hogarty GE (1984) Depot neuroleptics: the relevance of psychosocial factors — a United States perspective. J Clin Psychiat 45(5, Sec 2):36–42
Hong WW, Arvanitis LA (1996) Reduction of the positive symptoms of schizophrenia by “Seroquel”(ICI 204, 636): Results from phase II and III clinical trials. Europ Neuropsychopharm 6(suppl 4):S 4–125
Hyman SE (ed) (1984) The suicidal patient. In: Manual of psychiatric emergencies. Little, Brown, Boston Toronto
Inoue Y (1991) Mitteilung an den 17. Kongress des International College of Neuropsychopharmacology. In: Acad Prof Inf Serv NY (ed) Psychiatric topics, (3)1
Janssen PAJ, Van Bever WFM (1975) Advances in the search for improved neuroleptic drugs. Curr Dev Psychopharmacol 2:167
Janssen PAJ, Tollenaere JP (1982) Pimozide. In: Bindra JS, Lednicer D (eds) Chronicles of drug discovery, vol 2. John Wiley & Sons, New York, pp 33–47
Janssen PAJ, Niemegeers CJE, Awouters F et al (1988) Pharmacology of risperidone (R 64766) a new antipsychotic with serotonin-S2 and Dopamine-D2 antagonistic properties. J Pharmacol Exp Ther 244:685–693
Kähler HJ (1970) Rauwolfia Alkaloide. Boehringer, Mannheim
Kane JM, Rifkin A, Woerner M et al (1985) High-dose versus low-dose strategies in the treatment of schizophrenia. Psychpharmacol Bull 21, 3:533–537
Kane JM, Carson WH, Saha AR et al (2002) Efficacy and Safety of Aripiprazole and Haloperidol versus Placebo in Patients with Schizophrenia and Schizoaffective Disorder. J Clin Psychiatry 63(9):763–771
Kapsmabelis V, Gekiere CI, Ginestet D (1990 a) Classifications cliniques des neuroleptiques — étude critique et perspectives actuelles. Encephale 14:63–70
Kapsmabelis V, Serra P, Ginestet D (1990 b) Le syndrome déficitaire: historique, séneiologie et quelques réflexions. Nerv Psychiat 3 (Spec No Jan 1990)
Keck P, Buffenstein A, Ferguson J et al (1998) Ziprasidone 40 and 120 mg/day in the acute exacerbation of schizophrenia and schizoaffective disorder: a 4 week placebo controlled trial. Psychopharmacology 140:173–184
Kline NS (1954) Use of rauwolfia in neuropsychiatric conditions. Ann NY Acad Sci 59:107
Koro CE, Fedder DO, L’Italiana GJ et al (2002) An assessment of the independent effects of olanzapine and risperidone exposure on the risk of hyperlipidemia in schizophrenic patients. Arch Gen Psychiatry 50:1021–1026
Kupfer DJ, Sartorius N (eds) (2002) The Usefulness and Use of Second-Generation Antipsychotic Medications. Supplement to Current Opinion in Psychiatry, vol 15, suppl 1, March 2002
Laborit H (1951) L’anesthésie facilitée par les synergies médicamenteuses. Masson, Paris
Lambert PA, Revol L (1960) Classification psychopharmacologique et Unique des différents neuroleptiques. Indications thérapeutiques générales dans les psychoses. Presse Med 41:1509–1511
Lecrubier Y (1987) Doit-on envisager une classification des neuroleptiques tenant mieux compte des mécanismses d’action et des différents syndromes-cibles? Psychiat Psychobiol 2:232–238
Leff JP, Knipers L, Berkowitz R (1982) A controlled trial of social intervention in the families of schizophrenic patients. Br J Psychiat 141:121–134
Lenert LA, Ziegler J, Lee T (2000) Differences in health values among patients, family members and providers of outcome in schizophrenia. Med Care 10:1011–1021
Lindström L, Wieseigren IM, Akselson S et al (1990) Mitteilung an das Osloer Regionalsymposium der WPA. In: Acad Prof Inf Serv NY (ed) Psychiatrie topica (3)1
Martin S, Loo H, Peuskens J, Thirumalai Set al (2002) A Double-blind, Randomized Comparative Trial of Amisulpride versus Olanzapine in the Treatment of Schizophrenia: Short-term Results at Two Months. Current Medical Research and Opinians 18(6):355–362
May PRA, Tuma AH, Dixon WJ (1976 a) Schizophrenia — a follow-up study of results of treatment. I. Design and other problems. Arch Gen Pschiat 33:474–478
May PRA, Tuma AH, Yale C et al (1976 b) Schizophrenia — a follow-up study of results of treatment. II. Hospital stay over two to five years. Arch Gen Psychiat 33:481–486
Meltzer HY (2001) Treatment of suicidality in schizophrenia. Ann NY Acad Sci 932:44–58
Moldavsky M, Stein D, Benatov R et al (1998) Combined clozapine-lithium treatment for schizophrenia and schizoaffective disorder. Eur Psychiatry13:104–106
Müller P, Kind J, Lohrengel S et al (1977) Die neuroleptische Rezidivprophylaxe schizophrener Psychosen. Vorläufige Mitteilung. Nervenarzt 48:560–561
Mullen J, Jibson MD, Sweitzer D (2001) A Comparison of the Relative Safety, Efficacy and Tolerability of Quetiapine and Risperidone in Outpatients with Schizophrenia and other Psychotic Disorders: The Quetiapine Experience with Safety and Tolerability (QUEST) Study. Clinical Therapeutics 23(11):1839–1854
Naber D, Moritz S, Lambert M et al (2001) Improvement of schizophrenic patients subjective well-being under atypical antipsychotic drugs. Schizophr Res 50:79–88
Nasrallah HA, Duchesne I, Mehnert A, Janagap C (2002) Long acting risperidone injection improves quality of life. XXIII CINP, Montreal Canada
Niemeggers CJE, Awouters F, Janssen PAJ (1990) Antagonisme de la sérotonine impliqué dans l’éffet antipsychotique — confirmations par la ritansérine et le risperidone. Encephale 16:147–151
Oegren SO, Hall H, Koehler C et al (1983) Remoxipride, a new potential antipsychotic compound with selective antidopaminergic actions in the rat brain. Eur J Pharmacol 102:459–474
Petit M, Colonna L (1978) Critères de choix d’un neuroleptique. Entretiens de Bichat. Thérapeutique expansion scientifique francaise, Paris, pp 306–308
Rondot P, Bathien N (1979) Mouvements anormaux induits par les médicaments psychotropes. Encephale 5:41–48
Rouillon F (1988) Effects extrapyramidaux des neuroleptiques et leurs traitements. Synapse 43:81–88
Schneider W (1955) Die Erforschung der Rau wolf-Alkaloide von ihren Anfängen bis zur Gegenwart. Arzneimittelforschung (Drug Res) 5:666–672
Sechter D, Peuskens J, Fleurot O, Rein W, Lecrubier Y (2002) Amisulpiride vs Risperidone in Chronic Schizophrenia: Results of a 6-month Double-blind Study. Neuropsychopharm 27(6):1071–1081
Seeman M, Seeman P (2002) Choosing an Antipsychotic and Why.http://www.medscape.com/viewprogram/2013_pnt and 2014_pnt
Simon P, Lecrubier Y, Puech AJ (1984) Classification des neuroleptiques. Rev Pract 34, 13:589–594
Sowell MO, Mukhopadhyay N, Cavazzoni P et al (2002) Hyperglygemic Clamp Assessment of Insulin Secretory Responses in Normal Subjects Treated with Olanzapine, Risperidone, or Placebo. J Clin End Metab 87(6):2918–2923
Stevens BC (1973) Role of fluphenazine decanoate in lessening the burden of chronic schizophrenics on the community. Psychol Med 3:141–158
Task Force on late Neurological Effects of Antipsychotic Drugs (ed) (1980) Tardive dyskinesia: summary of a task force report of the American Psychiatric Association. Am J Psychiat 137:1163–1172
Tölle R (1986) Malignes neuroleptisches Syndrom. Dtsch Ärztebl 83:3102–3103
Vaughn CE, Leff J (1976) The influence of family and social factors on the course of psychiatric illness. A comparison of schizophrenic and depressed neurotic patients. Br J Psychiat 129:125–137
Vaughn CE, Sorensen Snyder K, Jones S (1984) Family factors in schizophrenic relapse. Arch Gen Psychiat 41:1169–1177
Volavka J, Czabor P, Sheitman B et al (2002) Clozapine, Olanzapine, Risperidone and Haloperidol in the Treatment of Patients with Chronic Schizophrenia and Schizoaffective Disorder. Am J Psychiatry 159:255–262
Voruganti L, Cortese L, Oyewumi L et al (2000) Comparative evaluation of conventional and novel antipsychotic drugs with reference to their subjective tolerability, side effect profile and impact on quality of life. Schizophr Res 43:135–145
Wadworth AN, Heel RC (1990) Remoxipride — a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in schizophrenia. Drugs 40(6):863–879
Weitbrecht HJ (1972) Depressive und manisch-depressive Psychosen. In: Kisker KP, Meyer JE, Müller M, Strögren E (Hrsg) Psychiatrie der Gegenwart, Bd. II 1, 2. Aufl. Springer, Berlin Heidelberg New York
Welch R, Chue P (2000) Antipsychotic agents and QT changes. J Psychiatry Neuroscience 25(2):154–160
WHO (ed) (1973) The international pilot study of schizophrenia, vol 1. WHO, Geneva
Woggon B (1979) Neuroleptikaabsetzversuche bei chronisch schizophrenen Patienten. I. Literaturzusammenfassung. Int Pharmacopsychiat 14:34
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Schmitz, M. (2004). Substanzgruppen. In: 1 × 1 der Psychopharmaka. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-7985-1927-5_4
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