Percutaneous transluminal aortic valve replacement: The CoreValve prosthesis

  • U. Gerckens
  • L. Büllesfeld
  • G. Latsios
  • R. Müller
  • B. Sauren
  • S. Iversen
  • Eberhard Grube


Open heart surgery with mechanical or porcine bioprosthetic valve replacement is the current gold-standard therapeutic approach for the vast majority of patients with severe aortic valve disease, offering symptomatic relief and improving long-term survival. However, the etiology of aortic stenosis in the Western population is primarily degenerative, and patients are typically elderly with multiple co-morbid conditions which increase surgical risk [1, 2, 3]. In high-risk patients with baseline features such as left ventricular failure, concomitant coronary artery disease, prior bypass graft surgery, chronic obstructive pulmonary disease and/or advanced age, expected operative mortality ranges from 10% to even 50% in high-risk patients subgroups [1]. Moreover, surgery is often not performed in high-risk patients. In the Euro Heart Survey, up to 33% of patients in NYHA functional class III/IV with a single diseased valve were declined for surgery or were never considered as surgical candidates, due to an expected short life expectancy and associated comorbid conditions [4]. alternative techniques for treatment of high-risk patients are therefore needed.


Aortic Valve Aortic Stenosis Aortic Valve Replacement Transcatheter Aortic Valve Implantation Aortic Valve Stenosis 
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© Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • U. Gerckens
  • L. Büllesfeld
  • G. Latsios
  • R. Müller
  • B. Sauren
  • S. Iversen
  • Eberhard Grube
    • 1
  1. 1.Medizinische Klinik Kardiologie — AngiologieHELIOS Klinikum SiegburgSiegburgGermany

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