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Systemic antibiotics in the prophylaxis and therapy of postoperative infections in patients with osteosynthesis of the femur

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Abstract

Infection is the outcome of various interactions between a host, a potential pathogen and the environment. Infection occurs, when micro-organisms successfully evade the host defense. Surgical wounds may heal by primary intention (with apposed wound edges) or secondary intention (when the wound is left open), whereas it has been shown that a delay of wound closure of four to five days increases the resistance to infection [11].

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References

  1. American Society of Health-System Pharmacists (1999) AHSP therapeutic guidelines on antimicrobial prophylaxis in surgery. Am J Health-Syst Pharm 56:1839–1888

    Google Scholar 

  2. Rittmann et al (1998) Stellenwert systemischer und lokaler Antibiotika-Anwendung bei Weichteil-und Knocheninfektionen. Helv Chir Acta 56: 876–889

    Google Scholar 

  3. Gillespie WJ, Walenkamp G (2001) Antibiotic prophylaxis for surgery for proximal femoral and other closed bone fractures. Cochrane database of Systematic Reviews Issue 1

    Google Scholar 

  4. Noer et al (1991) Dataregistering af postoperative komplikationer ved ortopaedkirurgiker operationer. Ugeskr Laeger 153:1587–1590

    PubMed  CAS  Google Scholar 

  5. Aargard et al (1994) Computer registration of infections used to measure the effect of prophylactic antibiotics on postoperative infections following osteosynthesis in hip fractures. J Hosp Infect 28:257–262

    Article  Google Scholar 

  6. Boyd et al (1973) A double blind clinical trial of prophylactic antibiotics in hip fractures. J Bone Jt Surg 55-A:1251–1258

    Google Scholar 

  7. Burnett et al (1980) Prophylactic antibiotics in hip fractures, a double-blind, prospective study. J Bone Jt Surg 62-A:457–461

    Google Scholar 

  8. Gatell et al (1984) Prophylactic cefamandole in orthopaedic surgery. J Bone Jt Surg 66-A:1219–1222

    Google Scholar 

  9. Mini et al (1997) Methicillin-resistant staphylococci in clean surgery. Is there a role for prophylaxis? Drugs 54/Suppl 6:39–52

    Article  Google Scholar 

  10. European Wound management association EWMA (2005) Position document: identifying criteria for Wound infection. MEP Ltd, London

    Google Scholar 

  11. Gottrup et al (2005) An overview of surgical site infections: aetiology, incidence and risk factors. World Wide Wounds, Sep

    Google Scholar 

  12. Bühler et al (2003) Septische postoperative Komplikationen. Springer

    Google Scholar 

  13. SPC Vancomycin Abbott, Version June 2005

    Google Scholar 

  14. SPC Claforan, sanofi-aventis, Version December 2006

    Google Scholar 

  15. Fletcher et al (2007) Prevention of perioperative infection. J Bone Surg Am 89:1605–1618

    Article  PubMed  Google Scholar 

  16. SPC Cefuroxim Fresenius 1500 mg, Version July 2004

    Google Scholar 

  17. Nehrer et al (1998) Teicoplanin in the prevention of infection in total hip replacement. Arch Orthop Trauma Surg 118:32–36

    Article  PubMed  CAS  Google Scholar 

  18. Zimmerli et al (2004) Prosthetic joint infections. N Engl J Med 351:16

    Article  Google Scholar 

  19. Periti et al (1998) Antimicrobial prophylaxis in orthopaedic surgery: the role of teicoplanin. JAC 41:329–340

    PubMed  CAS  Google Scholar 

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© 2008 Steinkopff Verlag

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Decker-Burgard, S. (2008). Systemic antibiotics in the prophylaxis and therapy of postoperative infections in patients with osteosynthesis of the femur. In: Dittel, KK., Rapp, M. (eds) The Double Dynamic Martin Screw (DMS). Steinkopff. https://doi.org/10.1007/978-3-7985-1842-1_18

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  • DOI: https://doi.org/10.1007/978-3-7985-1842-1_18

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-1841-4

  • Online ISBN: 978-3-7985-1842-1

  • eBook Packages: MedicineMedicine (R0)

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