Roles of Cellular and Molecular Targets of Wear Debris in Periprosthetic Osteolysis

  • Sang-Soo Lee
  • Jun-Dong Chang
  • P. E. Purdue
  • B. J. Nestor
  • T. P. Sculco
  • E. A. Salvati
Part of the Ceramics in Orthopaedics book series (CIO)


Wear-generated particulate debris is the main cause of initiating this destructive process. We present recent advances in understanding of how wear debris causes osteolysis in the aspect of cellular and molecular biological levels. Macrophages, the most important cellular target for wear debris, respond to particle challenge in two distinct ways of pro-inflammatory signaling and inhibition of the protective actions of anti-osteoclastogenic cytokines, finally leading to suppression of osteogenic activity as well as increased osteoclast activity. At a molecular level, such alterations of cellular activities occur through MAP kinase, transcription factors including NF-κB, Wnt/β-catenin signaling and cytokine signaling cascades in various kinds of cells.


Wear Debris Macrophage Colony Stimulate Factor Biomed Mater Periprosthetic Tissue Periprosthetic Osteolysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Steinkopff Verlag 2007

Authors and Affiliations

  • Sang-Soo Lee
    • 1
  • Jun-Dong Chang
    • 2
  • P. E. Purdue
  • B. J. Nestor
  • T. P. Sculco
  • E. A. Salvati
  1. 1.Chuncheon Sacred Heart HospitalOrthopedic Surgery Hallym UniversityGangwonKorea
  2. 2.Department of Orthopedic Surgery Hangang Sacred Heart HospitalHallym UniversitySeoulKorea

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