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Zusammenfassung

Eine Thrombose ist definiert als völliger oder partieller Verschluss eines Blutgefäßes durch ein Blutgerinnsel; eine Thromboembolie als Obstruktion eines Gefäßes durch Thrombusanteile, die sich an anderer Stelle im Organismus gebildet haben und von dort disloziert sind. Spontane Thrombosen sind Gefäßverschlüsse ohne zugrunde liegende Begleiterkrankung (exogene Risikofaktoren), von sekundären Thrombosen spricht man, wenn ein Gefäßverschluss auf dem Boden von Begleiterkrankungen, therapeutischen Interventionen oder nach Medikamentengabe entsteht.

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Literatur

  1. Nowak-Göttl U, Kosch A, Schlegel N (2001) Thromboembolism in newborns, infants and children. Thromb Haemost 86:464–474

    PubMed  Google Scholar 

  2. Andrew M, David M, Adams M et al (1994) Venous thromboembolic complications (VTE) in children: first analyses of the Canadian registry of VTE. Blood 83:1251–1257

    CAS  PubMed  Google Scholar 

  3. Schmidt B, Andrew M (1995) Neonatal thrombosis: report of a prospective Canadian and international registry. Pediatrics 96:939–943

    CAS  PubMed  Google Scholar 

  4. Nowak-Göttl U, von Kries R, Göbel U (1997) Neonatal symptomatic thromboembolism in Germany: two year survey. Arch Dis Child Fetal Neonatal Ed 76: F163–F167

    Article  PubMed  Google Scholar 

  5. Massicotte MP, Dix D, Monagle P, Adams M, Andrew M (1998) Central venous catheter related thrombosis in children: Analysis of the Canadian Registry of venous thromboembolic complications. J Pediatr 133:770–776

    Article  CAS  PubMed  Google Scholar 

  6. Van Ommen CH, Heijboer H, Buller HR, Hirasing RA, Heijmans HS, Peters M (2001) Venous thromboembolism in childhood: a prospective two-year registry in The Netherlands. J Pediatr 139:676–681

    Article  PubMed  Google Scholar 

  7. DeVeber G, Andrew M, Adams C et al (2001) Cerebral sinovenous thrombosis in children. N Engl J Med 345:417–423

    Article  CAS  PubMed  Google Scholar 

  8. Roy M, Turner-Gomes S, Gill G, Way C, Mernagh J, Schmidt B (2002) Accuracy of Doppler echocardiography for the diagnosis of thrombosis associated with umbilical venous catheters. J Pediatr 140:131–134

    Article  PubMed  Google Scholar 

  9. Male C, Chait P, Ginsberg JS et al (2002) Comparison of venography and ultrasound for the diagnosis of asymptomatic deep vein thrombosis in the upper body in children: Results of the PARKAA study. Thromb Haemost 87:593–659

    CAS  PubMed  Google Scholar 

  10. Junker R, Koch HG, Auberger K, Münchow N, Ehrenforth S, Nowak-Göttl U (1999) Prothrombin G20210A gene mutation and further prothrombotic risk factors in childhood thrombophilia. Arterioscler Thromb Vasc Biol 19:2568–2572

    CAS  PubMed  Google Scholar 

  11. Richtlinien zur prädiktiven genetischen Diagnostik. Deutsches ärzteblatt 100(19): A1297–1305, B1085–1093, C1013–1021

    Google Scholar 

  12. Nowak-Göttl U, Junker R, Hartmeier M et al (1999) Increased lipoprotein (a) is an important risk factor for venous thromboembolism in childhood. Circulation 100:743–748

    PubMed  Google Scholar 

  13. Lane DA, Manucci PM, Bauer KA et al (1996) Inherited thrombophilia: Part 2. Thromb Haemost 76:824–834

    CAS  PubMed  Google Scholar 

  14. Manco-Johnson MJ, Grabowski EF, Hellgreen M et al (2002) Laboratory testing for thrombophilia in pediatric patients. Thromb Haemost 88:155–156

    CAS  PubMed  Google Scholar 

  15. Ehrenforth S, Junker R, Koch HG et al (1999) Multicentre evaluation of combined prothrombotic defects associated with thrombophilia in childhood. Eur J Pediatr 158:S97–S104

    Article  PubMed  Google Scholar 

  16. Monagle P, Adams M, Mahoney M et al (2000) Outcome of pediatric thromboembolic disease: a report from the Canadian childhood thrombophilia registry. Pediatr Res 47:763–766

    Article  CAS  PubMed  Google Scholar 

  17. Nowak-Göttl U, Junker R, Kreuz W et al (2001) Risk of recurrent thrombosis in children with combined prothrombotic risk factors. Blood 97:858–862

    Article  PubMed  Google Scholar 

  18. Andrew M, Michelson AD, Bovill E, Leaker M, Massicotte MP (1998) Guidelines for antithrombic therapy in pediatric patients. J Pediatr 132:576–588

    Google Scholar 

  19. Manco-Johnson MJ, Grabowski EF, Hellgreen M et al (2002) Recommendations for tPA thrombolysis in children. Thromb Haemost 88:157–158

    CAS  PubMed  Google Scholar 

  20. Farnoux C, Camard O, Pinquier D et al (1998) Recombinant tissue-type plasminogen activator therapy of thrombosis in 16 neonates. J Pediatr 133:137–140

    Article  CAS  PubMed  Google Scholar 

  21. Weiner GM, Castle VP, DiPietro MA, Faix RG (1998) Successful treatment of neonatal arterial thromboses with recombinant tissue plasminogen activator. J Pediatr 133:133–136

    Article  CAS  PubMed  Google Scholar 

  22. Jacobs BR, Haygood M, Hingl J (2001) Recombinant tissue plasminogen activator in the treatment of central venous catheter occlusion in children. J Pediatr 139:593–596

    Article  CAS  PubMed  Google Scholar 

  23. Choi M, Massicotte MP (2001) The use of alteplase to restore patency of central venous lines in pediatric patients: A cohort study. J Pediatr 139:152–156

    Article  CAS  PubMed  Google Scholar 

  24. Massicotte MP, Adams M, Marzinotto V, Brooker LA, Andrew M (1996) Low-molecular-weight heparin in pediatric patients with thrombotic disease: A dose finding study. J Pediatr 128:313–318

    Article  CAS  PubMed  Google Scholar 

  25. Dix D, Andrew M, Marzinotto V, et al (2000) The use of low molecular weight heparin in pediatric patients: a prospective cohort study. J Pediatr 136:439–445

    Article  CAS  PubMed  Google Scholar 

  26. Hofmann S, Knoefler R, Lorenz N et al (2001) Clinical experience with low-molecular weight heparins in pediatric patients. Thromb Res 103:345–353

    Article  CAS  PubMed  Google Scholar 

  27. Nohe N, Flemmer A, Rümler R, Praun M, Auberger K (1999) The low molecular weight heparin dalteparin for prophylaxis and therapy of thrombosis in childhood: a report of 48 cases. Eur J Pediatr 158:S134–S139

    Article  CAS  PubMed  Google Scholar 

  28. Schmugge M, Risch L, Huber AR, Benn A, Fischer JE (2002) Heparin-induced thrombocytopenia-associated thrombosis in pediatric intensive care patients. Pediatrics 109:U69–U72

    Article  Google Scholar 

  29. Zöhrer B, Zenz W, Rettenbacher A et al (2001) Danaparoid sodium (Orgaran® in four children with heparin-induced thrombocytopenia type II. Acta Paediatr 90: 765–767

    Article  PubMed  Google Scholar 

  30. Manco-Johnson MJ, Nuss R, Hays T, Krupski W, Drose J, Manco-Johnson ML (2000) Combined thrombolytic and anticoagulant therapy for venous thrombosis in children. J Pediatr 136:446–453

    Article  CAS  PubMed  Google Scholar 

  31. Gupta AA, Leaker M, Andrew M et al (2001) Safety and outcomes of thrombolysis with tissue plasminogen activator for treatment of intravascular thrombosis in children. J Pediatr 139:682–688

    Article  CAS  PubMed  Google Scholar 

  32. Marlar RA, Mongomery RR, Broekmans AW (1989) Diagnosis and treatment of homozygous protein C-deficiency. Report of the Working Party on Homozygous Protein C Deficiency of the Subcommittee on Protein C and Protein S. International Committee on Thrombosis and Haemostasis. J Pediatr 114:528–534

    Article  CAS  PubMed  Google Scholar 

  33. Bernard GR, Vincent JL, Laterre PF et al (2001) Efficacy and Safety of recombinant human activated protein C for sepsis. N Eng J Med 344:699–709

    Article  CAS  Google Scholar 

  34. Streif W, Andrew M, Marzinotto V, Massicotte P et al (1999) Analysis of warfarin therapy in pediatric patients: a prospective cohort study of 319 patients. Blood 94:3007–3014

    CAS  PubMed  Google Scholar 

  35. Massicotte P, Marzinotto V, Vegh P, Adams M, Andrew M (1995) Home monitoring of warfarin therapy in children with a whole blood prothrombin time monitor. J Pediatr 127:389–394

    Article  CAS  PubMed  Google Scholar 

  36. Brenner BR, Nowak-Göttl U, Kosch A, Manco-Johnson M, Laposta M (2002) Diagnostic studies for thrombophilia in women on hormonal therapy and during pregnancy, and in children. Arch Pathol Lab Med 126:1296–1303

    PubMed  Google Scholar 

  37. Carcao MD, Blanchette VS, Dean JA et al (1998) The platelet function analyser (PFA-100): a novel in-vitro system for evaluation of primary haemostasis in children. Br J Haematol 101:70–73

    Article  CAS  PubMed  Google Scholar 

  38. Hathaway WE (1984) Use of antiplatelet agents in pediatric hypercoagulable states. Am J Dis Child 138:301–304

    CAS  PubMed  Google Scholar 

  39. Sträter R, Kurnik K, Heller C, Schobess R, Luigs P, Nowak-Göttl U (2001) Aspirin versus low-dose low-molecular-weight heparin: Antithrombotic therapy in pediatric stroke patients. A prospective follow-up study. Stroke 32:2554–2558

    Article  PubMed  Google Scholar 

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Nowak-Göttl, U. et al. (2010). Thrombosen im Kindesalter. In: Pourhassan, S., Sandmann, W. (eds) Gefäßerkrankungen im Kindes- und Jugendalter. Steinkopff. https://doi.org/10.1007/978-3-7985-1760-8_11

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  • DOI: https://doi.org/10.1007/978-3-7985-1760-8_11

  • Publisher Name: Steinkopff

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