Pathophysiology of Gastroesophageal Reflux Disease and Indication for Surgical Therapy

  • Karl-Hermann Fuchs


Gastroesophageal reflux disease is one of the most common diseases in western societies. The prevalence is estimated to be around 10% in those populations, if the presence of the disease is based on weekly or daily reflux symptoms [1–3]. The disease has been diagnosed more often due to increased and improved diagnostic activities, but there is also a true increase in incidence of the problem. Since it is related to western lifestyle, eating habits and environmental factors are discussed. In addition in recent years, detection of extraesophageal problems, especially respiratory symptoms and problems, is increasing, often related to reflux [4, 5]. A special interest in this disorder has emerged in the past 15 years since studies have shown the possible connection between reflux, the development of intestinal metaplasia in the esophagus, and the increase in the incidence of adenocarcinoma in Barrett’s esophagus [6–10].


Reflux Disease Lower Esophageal Sphincter Gastroesophageal Reflux Disease Antireflux Surgery Laparoscopic Antireflux Surgery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Steinkopff Verlag 2009

Authors and Affiliations

  • Karl-Hermann Fuchs
    • 1
  1. 1.Department of SurgeryMarkus-KrankenhausFrankfurt am MainGermany

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