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Anti-endotoxin antibodies

A cross-reactive and cross-protective monoclonal antibody against a conserved epitope of Escherichia coli and Salmonella enterica

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Diagnostik und Intensivtherapie bei Sepsis und Multiorganversagen

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Lipopolysaccharid (LPS, Endotoxin) ist ein potenter Aktivator der angeborenen Immunantwort und löst die Freisetzung einer Vielzahl proinflammatorischer Mediatoren aus. Diese unkontrollierte Immunreaktion ist für den lebensbedrohlichen Zustand von Sepsis-Patienten verantwortlich. Eine erfolgreiche Strategie zur Behandlung der Gram-negativen Sepsis muss daher neben einer antiinfektiösen Therapie, d.h. der Eliminierung der Erreger durch konventionelle Antibiotika, eine antiendotoxische Therapie, d.h. Neutralisation der Wirkung von LPS, beinhalten.

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Authors and Affiliations

  1. Leibnitz-Center for Medicine and Biosciences, Research Center Borstel, Parkallee 22, 23845, Borstel, Germany

    Müller-Loennies Sven, Brade Lore, Brade Helmut & Prof. Dr. Dr. h.c. Rietschel Th. Ernst

  2. Novartis Institute for Biomedical Research(NIBR), 4002, Basel, Switzerland

    Padova Di Franco

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  1. Müller-Loennies Sven
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  2. Padova Di Franco
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  1. Einheit für Multidisziplinäre Intensivmedizin (EMI), Universitätsklinikum Leipzig AÖR, Liebigstr. 20, 04104, Leipzig

    Lothar Engelmann

  2. Klinikum Hildesheim, Weinberg 1, 31134, Hildesheim

    Hans-Peter Schuster

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Sven, ML., Di Franco, P., Lore, B., Helmut, B., Ernst, R.T. (2006). Anti-endotoxin antibodies. In: Engelmann, L., Schuster, HP. (eds) Diagnostik und Intensivtherapie bei Sepsis und Multiorganversagen. Steinkopff. https://doi.org/10.1007/978-3-7985-1729-5_17

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  • DOI: https://doi.org/10.1007/978-3-7985-1729-5_17

  • Publisher Name: Steinkopff

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  • Online ISBN: 978-3-7985-1729-5

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