Tetralogy of Fallot


In anatomic terms, the malformation is characterized by four constant features: subpulmonary infundibular stenosis, ventricular septal defect, rightward deviation of the aortic valve with a biventricular origin of its leaflets, and right ventricular hypertrophy.


Cardiovascular Magnetic Resonance Ventricular Septal Defect Pulmonary Valve Ventricular Outflow Tract Pulmonary Valve Replacement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Azevedo CF, Hadlich MS, Albuquerque DC, Moll JN (2006) Images in cardiovascular medicine. Untreated tetralogy of Fallot with pulmonary atresia: giant aneurysm of an aortopulmonary collateral artery demonstrated by magnetic resonance imaging. Circulation 113:293–294CrossRefGoogle Scholar
  2. Babu-Narayan SV, Kilner PJ, Li W, Moon JC, Goktekin O, Davlouros PA, Khan M, Ho SY, Pennell DJ, Gatzoulis MA (2006) Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy of Fallot and its relationship to adverse markers of clinical outcome. Circulation 113:405–413PubMedCrossRefGoogle Scholar
  3. Beekman RP, Beek FJ, Meijboom EJ (1997) Usefulness of MRI for the pre-operative evaluation of the pulmonary arteries in Tetralogy of Fallot. Magn Reson Imaging 15:1005–1015PubMedCrossRefGoogle Scholar
  4. Bernardes RJ, Marchiori E, Bernardes PM, Monzo Gonzaga MB, Simoes LC (2006) A comparison of magnetic resonance angiography with conventional angiography in the diagnosis of tetralogy of Fallot. Cardiol Young 16:281–288PubMedCrossRefGoogle Scholar
  5. Boechat MI, Ratib O, Williams PL, Gomes AS, Child JS, Allada V (2005) Cardiac MR imaging and MR angiography for assessment of complex tetralogy of Fallot and pulmonary atresia. Radiographics 25:1535–1546PubMedCrossRefGoogle Scholar
  6. Buechel ER, Dave HH, Kellenberger CJ, Dodge-Khatami A, Prêtre R, Berger F, Bauersfeld U (2005) Remodelling of the right ventricle after early pulmonary valve replacement in children with repaired tetralogy of Fallot: assessment by cardiovascular magnetic resonance. Eur Heart J 26:2721–2727PubMedCrossRefGoogle Scholar
  7. Chen SJ, Chang CI, Chiu IS, Wang JK, Lin CD, Chen HY, Lue HC, Li YW (2001) Preoperative diagnosis by electron beam computed tomography and perioperative management of primary tracheal anomalies in tetralogy of Fallot. J Formos Med Assoc 100:26–31PubMedGoogle Scholar
  8. Choi BW, Park YH, Choi JY, Choi BI, Kim MJ, Ryu SJ, Lee JK, Sul JH, Lee SK, Cho BK, Choe KO (2001) Using electron beam CT to evaluate conotruncal anomalies in pediatric and adult patients. Am J Roentgenol 177:1045–1049Google Scholar
  9. Choi BW, Park YH, Lee JK, Kim MJ, Kim DJ, Ryu SJ, Cho BK, Choe KO (2003) Evaluation of the postshunt status with electron beam computed tomography in cyanotic congenital heart disease. Yonsei Med J 44:249–258PubMedGoogle Scholar
  10. Chowdhury UK, Pradeep KK, Patel CD, Singh R, Kumar AS, Airan B, Gulati GS, Kothari SS, Saxena A, Kalaivani M, Venugopal P (2006) Noninvasive assessment of repaired tetralogy of Fallot by magnetic resonance imaging and dynamic radionuclide studies. Ann Thorac Surg 81:1436–1442PubMedCrossRefGoogle Scholar
  11. Corno AF, Hurni M, Griffin H, Galal OM, Payot M, Sekarski N, Tozzi P, von Segesser LK (2002) Bovine jugular vein as right ventricle-to-pulmonary artery valved conduit. J Heart Valve Dis 11:242–247PubMedGoogle Scholar
  12. Corno AF, Qanadli SD, Sekarski N, Artemisia S, Hurni M, Tozzi P, von Segesser LK (2004) Bovine valved xenograft in pulmonary position: medium-term follow-up with excellent hemodynamics and freedom from calcifications. Ann Thorac Surg 78:1382–1388PubMedCrossRefGoogle Scholar
  13. Davlouros PA, Kilner PJ, Hornung TS, Li W, Francis JM, Moon JC, Smith GC, Tat T, Pennell DJ, Gatzoulis MA (2002) Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: detrimental role of right ventricular outflow aneurism or akinesia and adverse right-to-left ventricular interaction. J Am Coll Cardiol 40:2044–2052PubMedCrossRefGoogle Scholar
  14. Dodge-Khatami A, Buechel ER, Knirsch W, Kadner A, Rousson V, Dave HH, Bauersfeld U, Prêtre R (2006) Brain natriuretic peptide and magnetic resonance imaging in tetralogy with right ventricular dilatation. Ann Thorac Surg 82:983–988PubMedCrossRefGoogle Scholar
  15. Dorfman AL, Geva T (2006) Magnetic resonance imaging evaluation of congenital heart disease: conotruncal anomalies. J Cardiovasc Magn Reson 8:645–659PubMedCrossRefGoogle Scholar
  16. Eichhorn J, Schoenberg S, Ulmer HE (2003) Cardiacgated multislice computerised tomographic angiography in the preoperative evaluation of an infant with tetralogy of Fallot and pulmonary atresia. Cardiol Young 13:466–468PubMedGoogle Scholar
  17. Festa P, Ait-Ali L, Murzi B, Bini MR (2005) Tetralogy of Fallot with left heart hypoplasia, total anomalous pulmonary venous return, and right lung hypoplasia: role of magnetic resonance imaging. Pediatr Cardiol 26:467–469PubMedCrossRefGoogle Scholar
  18. Geva T, Greil GF, Marshall AC, Landzberg M, Powell AJ (2002) Gadolinium-enhanced three-dimensional magnetic resonance angiography of pulmonary blood supply in patients with complex pulmonary stenosis or atresia: comparison with X-ray angiography. Circulation 106:473–478PubMedCrossRefGoogle Scholar
  19. Geva T, Sahn DJ, Powell AJ (2003) Magnetic resonance imaging of congenital heart disease in adults. Progress in Pediatric Cardiology 17:21–39CrossRefGoogle Scholar
  20. Geva T, Sandweiss BM, Gauvreau K, Lock JE, Powell AJ (2004) Factors associated with impaired clinical status in long-term survivors of tetralogy of Fallot repair evaluated by magnetic resonance imaging. J Am Coll Cardiol 43:1068–1074PubMedCrossRefGoogle Scholar
  21. Gulati GS, Singh C, Kothari SS, Sharma S (2006) An unusual coronary artery anomaly in tetralogy of Fallot shown on MDCT. Am J Roentgenol 186:1192–1193CrossRefGoogle Scholar
  22. Halt M, Kastler B, Livolsi A, Mardini M, Willard D, Wackenheim A (1991) Tetralogy of Fallot: a preand post-operative study using magnetic resonance tomography. Röfo 154:111–113PubMedGoogle Scholar
  23. Harris MA, Johnson TR, Weinberg PM, Fogel MA (2007) Delayed-enhancement cardiovascular magnetic resonance identifies fibrous tissue in children after surgery for congenital heart disease. J Thorac Cardiovasc Surg 133:676–681PubMedCrossRefGoogle Scholar
  24. Helbing WA, de Roos A(2000) Clinical applications of cardiac magnetic resonance imaging after repair of tetralogy of Fallot. Pediatr Cardiol 21:70–79PubMedCrossRefGoogle Scholar
  25. Holmqvist C, Hochbergs P, Bjorkhem G, Brockstedt S, Laurin S (2001) Pre-operative evaluation with MR in tetralogy of Fallot and pulmonary atresia with ventricular septal defect. Acta Radiol 42:63–69PubMedCrossRefGoogle Scholar
  26. Kang IS, Redington AN, Bensol LN, Macgowan C, Valsangiacomo ER, Roman K, Kellenberger CJ, Yoo SJ (2003) Differential regurgitation in branch pulmonary arteries after repair of tetralogy of Fallot: a phase-contrast cine magnetic resonance study. Circulation 107:2938–2943PubMedCrossRefGoogle Scholar
  27. Kastler B, Livolsi A, Germain P, Zollner G, Dietemann JL (1991) Evaluation of Blalock-Taussig shunts in newborns: value of oblique MRI planes. Int J Card Imaging 7:1–5PubMedCrossRefGoogle Scholar
  28. Lajos PS, White C, Cardarelli M (2006) Multislice computed tomographic angiography: valuable tool in the diagnosis and planning of complex cardiac surgery. Ann Thorac Surg 81:2317PubMedCrossRefGoogle Scholar
  29. Li W, Davlouros PA, Kilner PJ, Pennell DJ, Gibson D, Henein MY, Gatzoulis MA (2004) Doppler-echocardiographic assessment of pulmonary regurgitation in adults with repaired tetralogy of Fallot: comparison with cardiovascular magnetic resonance imaging. Am Heart J 147:165–172PubMedCrossRefGoogle Scholar
  30. Menteer J, Wienberg PM, Fofel MA (2005) Quantifying regional right ventricular in tetralogy of Fallot. J Cardiovasc Magn Reson 7:753–761PubMedCrossRefGoogle Scholar
  31. Nieman K, Roos-Hesselink JW, de Feyter PJ (2003) Coronary anomaly imaging by multislice computed tomography in corrected tetralogy of Fallot. Heart 89:664PubMedCrossRefGoogle Scholar
  32. Norton KI, Tong C, Glass RB, Nielsen JC (2006) Cardiac MR imaging assessment following tetralogy of Fallot repair. Radiographics 26:197–211PubMedCrossRefGoogle Scholar
  33. Oosterhof T, Mulder BJ, Vliegen HW, de Roos A(2005) Corrected tetralogy of Fallot: delayed enhancement in right ventricular outflow tract. Radiology 237: 868–871PubMedCrossRefGoogle Scholar
  34. Oosterhof T, Mulder BJ, Vliegen HW, de Roos A (2006) Cardiovascular magnetic resonance in the follow-up of patients with corrected tetralogy of Fallot: a review. Am Heart J 151:265–272PubMedCrossRefGoogle Scholar
  35. Oosterhof T, Tulevski II, Vliegen HW, Spijkerboer AM, Mulder BJ (2006) Effects of volume and/or pressure overload secondary to congenital heart disease (tetralogy of Fallot or pulmonary stenosis) on right ventricular function using cardiovascular magnetic resonance and B-type natriuretic peptide levels. Am J Cardiol 97:1051–1055PubMedCrossRefGoogle Scholar
  36. Oosterhof T, van Straten A, Vliegen HW, Meijboom FJ, van Dijk AP, Spijkerboer AM, Bouma BJ, Zwinderman AH, Hazekamp MG, de Roos A, Mulder BJ (2007) Preoperative thresholds for pulmonary valve replacement in patients with corrected tetralogy of Fallot using cardiovascular magnetic resonance. Circulation 116:545–551PubMedCrossRefGoogle Scholar
  37. Niezen RA, Helbing WA, van der Wall EE, van der Geest RJ, Vliegen HW, de Roos A (1999) Left ventricular function in adults with mild pulmonary insufficiency late after Fallot repair. Heart 82:697–703PubMedGoogle Scholar
  38. Prakash A, Powell AJ, Krishnamurthy R, Geva T (2004) Magnetic resonance imaging evaluation of myocardial perfusion and viability in congenital and acquired pediatric heart disease. Am J Cardiol 93:657–661PubMedCrossRefGoogle Scholar
  39. Powell AJ, Chung T, Landzberg MJ, Geva T (2000) Accuracy of MRI evaluation of pulmonary blood supply in patients with complex pulmonary stenosis or atresia. Int J Card Imaging 16:169–174PubMedCrossRefGoogle Scholar
  40. Puderbach M, Eichhorn J, Fink C, Kauczor HU (2004) Images in cardiovascular medicine. Untreated tetralogy of Fallot with pulmomary atresia in a 55-yearold woman: findings from magnetic resonance imaging. Circulation 110:e461–462PubMedCrossRefGoogle Scholar
  41. Raman SV, Cook SC, McCarthy B, Ferketich AK (2005) Usefulness of multidetector row computed tomography to quantify right ventricular size and function in adults with either tetralogy of Fallot or transposition of the great arteries. Am J Cardiol 95:683–686PubMedCrossRefGoogle Scholar
  42. Rebergen SA, Chin AJ, Ottenkamp J, van der Wall EE, de Roos A (1993) Pulmonary regurgitation in the late postoperative follow-up of tetralogy of Fallot. Volumetric quantitation by nuclear magnetic resonance velocity mapping. Circulation 88:2257–2266PubMedGoogle Scholar
  43. Redington AN (2006) Determinants and assessment of pulmonary regurgitation in tetralogy of Fallot: practice and pitfalls. Cardiol Clin 24:631–639PubMedCrossRefGoogle Scholar
  44. Rodrigo Carbonero D, Cabreara Duro A, Martinez Corrales P, Rios Altolaguirre G, Alcibar Villa J, Aramendi Gallardo J, Barrera Portillo MC, Pastor Menchaca E, Cabrera Zubizarreta A (2004) Magnetic resonance imaging and lung perfusion scintigraphy in tetralogy of Fallot following surgery. An Pediatr 60:153–160CrossRefGoogle Scholar
  45. Roest AA, Helbing WA, Kunz P, van den Aardweg JG, Lamb HJ, Vliegen HW, van der Wall EE, de Roos A (2002) Exercise MR imaging in the assessment of pulmonary regurgitation and biventricular function in patients after tetralogy of Fallot repair. Radiology 223:204–211PubMedCrossRefGoogle Scholar
  46. Roest AA, de Roos A, Lamb HJ, Helbing WA, van den Aardweg JG, Doornbos J, van der Wall EE, Kunz P (2003) Tetralogy of Fallot: postoperative delayed recovery of left ventricular stroke volume after physical exercise assessment with fast MR imaging. Radiology 226:278–284PubMedCrossRefGoogle Scholar
  47. Schievano S, Migliavacca F, Coats L, Khambadkone S, Carminati M, Wilson N, Deanfield JE, Bonhoeffer P, Taylor AM (2007) Percutaneous pulmonary valve implantation based on rapid prototyping of right ventricular outflow tract and pulmonary trunk from MR data. Radiology 242:490–497PubMedCrossRefGoogle Scholar
  48. Therrien J, Provost Y, Merchant N, Williams W, Colman J, Webb G (2005) Optimal timing for pulmonary valve replacement in adults after tetralogy of Fallot repair. Am J Cardiol 95:779–782PubMedCrossRefGoogle Scholar
  49. Tsai SK, Chang CI, Wang MJ, Chen SJ, Chiu IS, Chen YS, Lue HC (2001) The assessment of the proximal left pulmonary artery by transoesophageal echocardiography and computed tomography in neonates and infants: a case series. Anesth Analg 93:594–597PubMedCrossRefGoogle Scholar
  50. Van den Berg J, Wielopolski PA, Meijboom FJ, Witsenburg M, Bogers AJ, Pattynama PM, Helbing WA (2007) Diastolic function in repaired tetralogy of Fallot at rest and during stress: assessment with MR imaging. Radiology 243:212–219PubMedCrossRefGoogle Scholar
  51. Van Straten A, Vliegen HW, Lamb HJ, Roes SD, van der Wall EE, Hazekamp MG, de Roos A (2005) Time course of diastolic and systolic function improvement after pulmonary valve replacement in adult patients with tetralogy of Fallot. J Am Coll Cardiol 46:1559–1564PubMedCrossRefGoogle Scholar
  52. Vick GW 3rd, Wendt RE 3rd, Rokey R (1994) Comparison of gradient echo with spin echo magnetic resonance imaging and echocardiography in the evaluation of major aortopulmonary collateral arteries. Am Heart J 127:1341–1347PubMedCrossRefGoogle Scholar
  53. Vliegen HW, van Straten A, de Ross A, Roest AA, Schoof PH, Zwinderman AH, Ottenkamp J, van der Wal EE, Hazekamp MG (2002) Magnetic resonance imaging to assess the hemodynamic effects of pulmonary valve replacement in adults late after repair of tetralogy of Fallot. Circulaton 106:1703–1707CrossRefGoogle Scholar
  54. Wu MT, Huang YL, Hsieh KS, Huang JT, Peng NJ, Pan JY, Huang JS, Yang TL (2007) Influence of pulmonary regurgitation inequality on differential perfusion of the lungs in tetralogy of Fallot after repair. A phase-contrast magnetic resonance imaging and perfusion scintigraphy study. J Am Coll Cardiol 49: 1880–1886PubMedCrossRefGoogle Scholar

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