The physiology of blood flow and artery wall


Arterial hemodynamics play an important role in the genesis and progression of vascular diseases and anastomoses outcome [1]. Flow dynamics on the vessel bifurcation and on the vascular anastomosis and the mechanical properties of artery wall seem to play an important role in the development of myointimal hyperplasia. Non-physiological or turbulent flow fields like flow stagnation, flow separation, recirculation, as well as intramural stress distributions promote atherosclerotic disease and myointimal proliferation (Fig. 1).


Wall Shear Stress Artery Wall Fluid Shear Stress Arterial Compliance Piezoelectric Crystal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Asakura T, Karino T (1990) Flow patterns and spatial distribution of atherosclerotic lesions in human coronary arteries. Circ Res 66:1045–1066PubMedGoogle Scholar
  2. 2.
    Hopkins RW (1991) Presidential address. In: Bernoulli D, Young T, Poiseuille JLM, Simone FA (eds) Energy, Poise, and Resilience. J Vasc Surg 13:777–784Google Scholar
  3. 3.
    Wolf S, Werthenssen N (1979) Dynamics of arterial flow. Plenum Press, New YorkGoogle Scholar
  4. 4.
    Nichols WW, O’Rourke MF (1990) McDonald’s blood flow in arteries, theoretic, experimental and clinical principles, 3rd ed. Lea & Febiger, Philadelphia London, pp 38–56Google Scholar
  5. 5.
    Zarins CK, Zatina MA, Giddens DP, Ku DN, Glagov S (1987) Shear stress regulation of artery lumen diameter in experimental atherogenesis. J Vasc Surg 5:413–420PubMedCrossRefGoogle Scholar
  6. 6.
    Zhuang YJ, Singh TM, Zarins CK, Masuda H (1998) Sequential increases and decreases in blood flow stimulates progressive intimal thickening. Eur J Vasc Endovasc Surg 16:301–310PubMedCrossRefGoogle Scholar
  7. 7.
    Gnasso A, Carallo C, Irace C, Spagnuolo V, de Novara G, Mattioli PL (1996) Association between intima-media thickness and wall shear stress in common carotid arteries in heatthy male subjects. Circulation 94:3257–3262PubMedGoogle Scholar
  8. 8.
    Davies PF, Tripathi SC (1993) Mechanical stress mechanisms and the cell: an endothelial paradigm. Circ Res 72:239–245PubMedGoogle Scholar
  9. 9.
    Malek AM, Izumo S (1994) Molecular aspects of signal transduction of shear stress in the endothelial cell. J Hypertens 12:989–999PubMedCrossRefGoogle Scholar
  10. 10.
    Mohan S, Mohan N, Valente AJ, Sprague EA (1999) Regulation of low shear flow-induced HAEC VCAM-1 expression and monocyte adhesion. Am J Physiol 276:C1100–1107PubMedGoogle Scholar
  11. 11.
    Hehrlein C, Chuang CH, Tuntelder JR, Tatsis GP, Littmann L, Svenson RH (1991) Effects of vascular runoff on myointimal hyperplasia after mechanical balloon or thermal laser arterial injury in dogs. Circulation 84:884–890PubMedGoogle Scholar
  12. 12.
    Zarins CK, Giddens DP, Bharadvaj BK, Sottiurai VS, Mabon RF, Glagov S (1983) Carotid bifurcation atherosclerosis: quantitative correlation of plaque localization with flow velocity profiles and wall shear stress. Circ Res 53:502–514PubMedGoogle Scholar
  13. 13.
    Pedersen EM, Oyre S, Agerbaek M, Kristensen IB, Ringgaard S, Boesiger P et al. (1999) Distribution of early atherosclerotic lesions in the human abdominal aorta correlates with wall shear stresses measured in vivo. Eur J Vasc Endovasc Surg 18:328–333PubMedCrossRefGoogle Scholar
  14. 14.
    Malek AM, Alper SL, Izumo S (1999) Hemodynamic shear stress and its rote in atherosclerosis. JAMA 282:2035–2042PubMedCrossRefGoogle Scholar
  15. 15.
    Berguer R, Higgins RF, Reddy DJ (1980) Intimal hyperplasia. An experimental study. Arch Surg 115(3):332–335PubMedGoogle Scholar
  16. 16.
    Dobrin PB, Littooy FN, Endean ED (1989) Mechanical factors predisposing to intimal hyperplasia and medial thickening in autogenous vein grafts. Surgery 105(3):393–400PubMedGoogle Scholar
  17. 17.
    Dobrin PB (1995) Mechanical factors associated with the development of intima and medial thickening in vein grafts subjected to arterial pressure. Hypertension 26:38–43PubMedGoogle Scholar
  18. 18.
    Meyerson SL, Skelly CL, Curi MA et al. (2001) The effects of extremely low shear stress on cellular proliferation and neointimal thickening in the failing bypass graft. J Vasc Surg 34:90–97PubMedCrossRefGoogle Scholar
  19. 19.
    Dobrin PB (1978) Mechanical properties of arteries. Physiol Rev 58:397–460PubMedGoogle Scholar
  20. 20.
    Cox RH (1978) Passive mechanics and connective tissue composition of canine arteries. Am J Physiol 234:H533–H541PubMedGoogle Scholar
  21. 21.
    Schonfeld D, Atabek HB, Patel DJ (1979) Geometry and elastic response of the aorto iliac juntion. J Biomech 12:483–489PubMedCrossRefGoogle Scholar
  22. 22.
    Doyle JM, Dobrin PB (1973) Stress gradients in the walls of large arteries. J Biomech 6:631–639PubMedCrossRefGoogle Scholar
  23. 23.
    Lawton RW (1957) Some aspects of research in biological elasticity. Introductory remarks. In: Remington JW (ed) Tissue elasticity. Am Physiol Soc, Washington, DC, pp 1–11Google Scholar
  24. 24.
    Patel DJ, Fry DL (1964) In situ pressure-radius-length measurements in ascending aorta of anesthetized dogs. J Appl Physiol 19:413–416PubMedGoogle Scholar
  25. 25.
    Patel DJ, Fry DL (1966) Longitudinal tethering of arteries in dogs. Circ Res 19:1011–1021PubMedGoogle Scholar
  26. 26.
    Tozzi P, Hayoz D, Oedman C, Mallabiabarrena I, von Segesser LK (2001) Systolic axial artery length reduction: an overlooked phenomenon in vivo. Am J Physiol Heart Circ Physiol 280(5):H2300–H2305PubMedGoogle Scholar
  27. 27.
    Arndt JO, Kober G (1970) Pressure diameter relationship of the intact femoral artery in conscious man. Pflugers Arch 318:130–146PubMedCrossRefGoogle Scholar
  28. 28.
    Weizsacker HW, Pinto JG (1988) Isotropy and anisotropy of the arterial wall. J Biomech 21(6):477–487PubMedCrossRefGoogle Scholar
  29. 29.
    Lichtenstein O, Safar ME, Poitevin P, Levy BI (1995) Biaxial mechanical properties of carotid arteries from normotensive and hypertensive rats. Hypertension 26(1):15–19PubMedGoogle Scholar
  30. 30.
    Tozzi P, Hayoz D, Corno AF, Mallabiabarrena I, von Segesser LK (2003) Cross-sectional compliance overestimates arterial compliance because it neglects the axial strain. Swiss Med Wkly 133:461–464PubMedGoogle Scholar

Copyright information

© Steinkopff Verlag Darmstadt 2007

Personalised recommendations