Optimal Allocation Proportion for a Two-Treatment Clinical Trial Having Correlated Binomial Responses
Optimal allocation designs for the allocation proportion are obtained in the present paper for a two-treatment clinical trial, in the presence of possible correlation between the proportion of successes for two treatments. The possibility of such correlation is motivated by real data. It is observed that the optimal allocation proportions highly depend on the correlation.
KeywordsThrombolytic Therapy Optimal Allocation Allocation Proportion Binomial Response Optimal Adaptive Design
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The authors wish to thank two anonymous referees for their careful reading and constructive suggestions which led to some improvement over an earlier version of the manuscript. The research of S. Mandal is supported by a Discovery Grant from the Natural Sciences and Engineering Research Council (NSERC) of Canada.
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