Abstract
Combination drug therapy offers much promise for discovering pharmaceutical treatments that are efficacious and safe. A key efficacy criterion for a combination of two compounds is that the combination is superior to both of its component compounds used alone. This article proposes a simultaneous testing procedure, based upon step-down trend tests, that identifies dose combinations for pairs of compounds that produce efficacy results with excess over highest single agent (i.e. the combination is superior to both of the component compounds). This testing procedure is applied to data from experiments for a pilot high-throughput screening study for pairs of compounds evaluated at nine dose levels using 9 × 9 factorial experiments. This procedure is easily automated for high-throughput screening and can be computed using the SAS® MULTTEST procedure.
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Peterson, J.J. (2010). A Bonferroni-Adjusted Trend Testing Method for Excess over Highest Single Agent. In: Giovagnoli, A., Atkinson, A., Torsney, B., May, C. (eds) mODa 9 – Advances in Model-Oriented Design and Analysis. Contributions to Statistics. Physica-Verlag HD. https://doi.org/10.1007/978-3-7908-2410-0_21
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DOI: https://doi.org/10.1007/978-3-7908-2410-0_21
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