Neural Network Predictions of Significant Coronary Artery Stenosis in Women
Records from 1009 female coronary angiography patients were analyzed by artificial neural network. An outcome in each record, any coronary artery stenosis greater than 50% formed the dichotomous supervisory variable for the neural network. The network contained 19 and 30 elements in the input and middle layers respectively. A single output element corresponded to the supervisory variable. Patient records were ordered according to the date of the angiography and placed into four files. The first 409 records comprised the training file on which the network was trained by the method of backpropagation of errors with momentum. The next 400 records formed a cross-validation file on which the performance of the trained network was optimized. The next 100 records was a cutoff determination file, the file used to determine the output of the network, which distinguished significant stenosis. The cutoff was applied to the 100 records of the test file. ROC analysis revealed that a cutoff of 0.30 maximized specificity while maintaining perfect sensitivity in the cutoff determination file. The cutoff of 0.30 also maintained perfect sensitivity in the test file, while the trained network made output predictions less than 0.30 for 9 of 38 (24%) women who had no stenosis greater than 50%. Therefore the neural network system allowed the correct identification of 24% of the false positives from pre-angiographic diagnostic systems without making a single false negative prediction.
KeywordsReceiver Operating Characteristic Artificial Neural Network Coronary Angiography Receiver Operating Characteristic Curve Receiver Operating Characteristic Analysis
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