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Pharmacokinetics and pharmacodynamics of drugs abused in driving

  • Marilyn A. Huestis
  • Michael L. Smith

Abstract

Driving under the influence of impairing drugs is a prevalent and preventable worldwide problem. Scientists are conducting pharmacodynamic and pharmacokinetic studies to help officials identify drugged drivers and remove them from the roadways. Current approaches for drugs of abuse other than alcohol first determine an estimate of time of use from concentrations of drugs and metabolites in bodily fluids following controlled drug administration. The degree of driving impairment is then suggested based on the time course of effects from pharmacodynamic studies. Reasonable estimates of impairment can be made based on currently available studies for cannabis, cocaine, amphetamines and opioids. Predictive models were published relating cannabinoid concentrations in plasma and whole blood with time of use following various routes of administration and doses. Results of performance tests and driving simulators after controlled cannabis dosing document impairment at various times after use and show that impairment can last up to eight hours for many tasks and 24 hours for complex divided-attention tasks. A few studies on other drugs report expected plasma or oral fluid concentrations with time after drug administration. Degree of impairment is dependant on dose, route of administration, and tolerance. Further pharmacokinetic and pharmacodynamic studies are needed to guide drug concentration interpretation, to develop predictive models for other drugs, and to guide development of science-based drugged driving legislation.

Keywords

Cannabis User Anal Toxicol Cocaine Paste WUHDWHG ZLWK FRUUHODWLRQ EHWZHHQ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag/Switzerland 2009

Authors and Affiliations

  • Marilyn A. Huestis
    • 1
  • Michael L. Smith
    • 2
  1. 1.Chemistry and Drug Metabolism, Intramural Research ProgramNational Institute on Drug Abuse, National Institutes of HealthBaltimoreUSA
  2. 2.The Armed Forces Medical Examiner System, Division of Forensic ToxicologyArmed Forces Institute of PathologyRockvilleUSA

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